New insights into autophagy in inflammatory subtypes of asthma

Abstract

Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment.

Autophagy in chronic rhinosinusitis with or without nasal polyps

“…It accomplishes this by delivering cytoplasmic components to lysosomes for degradation and amino acid recycling through macroautophagy, chaperone-mediated autophagy, and microautophagy pathways ( Esclatine et al, 2009 ; Feng et al, 2014 ; Munz, 2014 ). Dysregulation of autophagy has been linked to various diseases such as cancer, neurodegenerative diseases, reproductive system diseases, and inflammatory diseases ( Chandrasekaran et al, 2023 ; Debnath et al, 2023 ; Dong et al, 2023 ; Kirat et al, 2023 ). Recent research has highlighted the importance of autophagy in the immune system, where it aids in pathogen removal, immune cell differentiation, antigen presentation, and regulation of inflammatory responses ( Germic et al, 2019 ; Munz, 2021 ; Shariq et al, 2023 ).…”