“…Recent studies have indicated that naturally occurring food compounds can regulate macrophage polarization, such as Laminaria japonica polysaccharide, scoparone, and baicalein. − Naturally occurring food compounds have garnered extensive attention due to their good biocompatibility and low production cost, making them potential options for regulating macrophage polarization and associated diseases . Sulforaphene (SFE) is one of the major isothiocyanates derived from radish seeds possessing the advantages of being readily isolated in large quantities, high purity, and low cost. , Multiple studies have substantiated its pronounced inhibitory capabilities against various types of cancer cells. , Furthermore, SFE has displayed notable antibacterial properties against various bacterial strains, including oral pathogens. , In recent years, studies have also shed light on the anti-inflammatory properties of SFE, elucidating its inhibitory effects on colitis, adipogenesis, and Alzheimer’s disease. − However, the impact of SFE on the polarization of macrophages and periodontitis remains unknown.…”