New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

Caliceti, Cristiana; Punzo, Angela; Silla, Alessia; Simoni, Patrizia; Roda, Giulia; Hrelia, Silvana

doi:10.3390/nu14142964

Cited by 28 publications

(27 citation statements)

References 176 publications

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“…Conjugation increases the water solubility of BAs before their hepatic secretion [ 53 ]. Moreover, conjugated BAs are nonabsorbable and indigestible in the proximal small intestine where lipid absorption takes place [ 49 , 58 ]. BSEP mutations may induce the development of cholestatic liver diseases such as progressive familial intrahepatic cholestasis type 2 (PFIC-2) and benign recurrent intrahepatic cholestasis type 2 (BRIC-2).…”

Section: Bile Acids and Their Importance In The Liver And Gut Metabolismmentioning

confidence: 99%

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Kasztelan-Szczerbińska

Rycyk-Bojarzynska

Szczerbinska

et al. 2023

Nutrients

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Primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are rare immune-related cholangiopathies with still poorly explained pathogenesis. Although triggers of chronic inflammation with subsequent fibrosis that affect cholangiocytes leading to obliteration of bile ducts and conversion to liver cirrhosis are unclear, both disorders are regarded to be multifactorial. Different factors can contribute to the development of hepatocellular injury in the course of progressive cholestasis, including (1) body accumulation of bile acids and their toxicity, (2) decreased food intake and nutrient absorption, (3) gut microbiota transformation, and (4) reorganized host metabolism. Growing evidence suggests that intestinal microbiome composition not only can be altered by liver dysfunction, but in turn, it actively impacts hepatic conditions. In this review, we highlight the role of key factors such as the gut–liver axis, intestinal barrier integrity, bile acid synthesis and circulation, and microbiome composition, which seem to be strongly related to PBC and PSC outcome. Emerging treatments and future therapeutic strategies are also presented.

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Section: Bile Acids and Their Importance In The Liver And Gut Metabolismmentioning

confidence: 99%

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Kasztelan-Szczerbińska

Rycyk-Bojarzynska

Szczerbinska

et al. 2023

Nutrients

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“…The osmotic pressure gradient that arises during the secretion of BAs into the bile ducts is one of the most important factors ensuring the proper flow of bile through the liver [ 45 , 57 ]. Due to their detergent properties, BAs can damage the cell membranes of the biliary epithelium and, consequently, damage the liver parenchyma [ 67 , 68 , 69 , 70 ].…”

Section: Bile Acidsmentioning

confidence: 99%

Bile Acids in Intrahepatic Cholestasis of Pregnancy

et al. 2022

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Intrahepatic cholestasis of pregnancy (ICP) is the most common, reversible, and closely related to pregnancy condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Due to the complex interactions between the mother and the fetus in metabolism and transplacental BAs transport, ICP is classified as a fetal-maternal disease. The disease is usually mild in pregnant women, but it can be fatal to the fetus, leading to numerous complications, including intrauterine death. The pathophysiology of the disease is based on inflammatory mechanisms caused by elevated BA levels. Although ICP cannot be completely prevented, its early diagnosis and prompt management significantly reduce the risk of fetal complications, the most serious of which is unexpected intrauterine death. It is worth emphasizing that all diagnostics and management of ICP during pregnancy are based on BA levels. Therefore, it is important to standardize the criteria for diagnosis, as well as recommendations for management depending on the level of BAs, which undoubtedly determines the impact on the fetus. The purpose of this review is to present the potential and importance of BAs in the detection and rules of medical procedure in ICP.

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“…Excreted primary bile acids are either absorbed or circulate in the enterohepatic circulation after being converted to secondary bile acids by intestinal bacteria (14). In recent years, bile acids have attracted great attention because they have been reported to stimulate various immune systems (15). Polyunsaturated fatty acid (PUFA) metabolites, such as eicosanoids and docosanoids, are biosynthesized from fatty acids cleaved from phospholipids that make up cell membranes by PLA2 (16,17).…”

Section: Introductionmentioning

confidence: 99%

Wide scope analysis of bioactive lipids, including steroids, bile acids, and polyunsaturated fatty acid metabolites, in human plasma by LC/MS/MS

Nakatani

Izumi

Umakoshi

et al. 2023

Preprint

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Quantitative information on blood metabolites has the potential to be utilized in medical strategies such as early disease detection and prevention. Monitoring of bioactive lipids, such as steroids, bile acids, and polyunsaturated fatty acid (PUFA) metabolites, could be a valuable indicator for health status. However, a method for simultaneous measurement of these bioactive lipids has not been reported at present. Here, we report a liquid chromatography tandem mass spectrometry (LC/MS/MS) method that can simultaneously measure more than 140 bioactive lipids, including steroids, bile acids, and PUFA metabolites, from human plasma, and a sample preparation method for these targets. Protein removal in methanol precipitation and purification operations of bioactive lipids by solid-phase extraction improved the recovery of targeted compounds in human plasma samples, demonstrating the importance of sample preparation methods in a wide range of bioactive lipid analyses. Using the developed method, we measured plasma from healthy human volunteers and confirmed the presence of bioactive lipid molecules associated with sex differences and circadian rhythms. The practical bioactive lipid analysis method developed is expected to be applied to health monitoring and disease biomarker discovery for precision medicine.

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New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer

Cited by 28 publications

References 176 publications

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Bile Acids in Intrahepatic Cholestasis of Pregnancy

Wide scope analysis of bioactive lipids, including steroids, bile acids, and polyunsaturated fatty acid metabolites, in human plasma by LC/MS/MS

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