New Insights into Diabetic and Vision-Threatening Retinopathy: Importance of Plasma Long Pentraxine 3 and Taurine Levels

Güngel, Hülya; Erdenen, Füsun; Paşaoğlu, Işıl; Sak, Duygu; Öğreden, Tülin; Müftüoğlu, İlkay Kılıç

doi:10.1080/02713683.2020.1836228

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…This has prompted investigations into the role of PTX3 as a marker of disease in DR, with conflicting outcomes. In fact, higher PTX3 levels have been documented in the plasma (or serum) of DR patients, compared to that of diabetics with no retinopathy or non-diabetic volunteers (Yang et al, 2014;Zhou and Hu, 2016;Erdenen et al, 2018;Elbana et al, 2019), however these findings have not been recapitulated in other studies (Chodkowski et al, 2018;Hokazono et al, 2018;Güngel et al, 2021). Such lack of consistency is likely due to high variability in the plasmatic concentration of PTX3 in diabetic patients, as a reflection of varying extents of hyperglycemiadependent damage to tissues and vascular beds.…”

Section: Emerging Roles Of Ptx3 In Drmentioning

confidence: 96%

The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy

et al. 2022

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Age related macular degeneration (AMD) and diabetic retinopathy (DR) are multifactorial, neurodegenerative and inflammatory diseases of the eye primarily involving cellular and molecular components of the outer and inner blood-retina barriers (BRB), respectively. Largely contributed by genetic factors, particularly polymorphisms in complement genes, AMD is a paradigm of retinal immune dysregulation. DR, a major complication of diabetes mellitus, typically presents with increased vascular permeability and occlusion of the retinal vasculature that leads, in the proliferative form of the disease, to neovascularization, a pathogenic trait shared with advanced AMD. In spite of distinct etiology and clinical manifestations, both pathologies share common drivers, such as chronic inflammation, either of immune (in AMD) or metabolic (in DR) origin, which initiates and propagates degeneration of the neural retina, yet the underlying mechanisms are still unclear. As a soluble pattern recognition molecule with complement regulatory functions and a marker of vascular damage, long pentraxin 3 (PTX3) is emerging as a novel player in ocular homeostasis and a potential pharmacological target in neurodegenerative disorders of the retina. Physiologically present in the human eye and induced in inflammatory conditions, this protein is strategically positioned at the BRB interface, where it acts as a “molecular trap” for complement, and modulates inflammation both in homeostatic and pathological conditions. Here, we discuss current viewpoints on PTX3 and retinal diseases, with a focus on AMD and DR, the roles therein proposed for this pentraxin, and their implications for the development of new therapeutic strategies.

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Section: Emerging Roles Of Ptx3 In Drmentioning

confidence: 96%

The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy

et al. 2022

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Assessment of serum Pentraxin3 level in Iraq patients with and without Diabetic Retinopathy

Hassan

Hamdi

Al.Mohammadaw

et al. 2023

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Diabetic retinopathy is the main cause of vision loss worldwide. It is considered one of the most severe diabetic microvascular complications affecting the retina's blood vessels due to prolonged hyperglycemia. Pentraxin 3 is an acute-phase glycoprotein that is correlated with inflammation. Inflammation is mechanistically involved in the development of diabetic retinopathy. This study aims to measure serum pentraxin3 levels in type 2 diabetic patients with and without retinopathy and compare their levels to controls. Also, investigate the relationship between circulating pentraxin3 and the development of diabetic retinopathy. This case–control study included one hundred and twenty (120) individuals aged 40 to 70 years. Individuals were divided into 3 groups: Group 1 included 40 types 2 diabetic patients with retinopathy, group 2 included 40 type 2 diabetic patients without retinopathy and group 3- included 40 persons as controls. Significant increase in the mean value of serum pentraxin3 in the diabetic patient with retinopathy as compared to diabetic patients with and without retinopathy as compared to and control(p=0.000) as well as a significant increase in the mean value of serum pentraxin3 in the diabetic patient with retinopathy as compared to diabetic patients without retinopathy (p=0.000). In addition, a significant positive correlation was found between serum pentraxin3 level and HbA1C in diabetic patients with retinopathy group (r=0.936, p= 0.0001). Higher serum level of pentraxin 3 in diabetic patients with retinopathy and its association with poor glycemic control, as well as pentraxin 3, is an acute-phase reactant, so serum pentraxin 3 levels may have a significant role in the initiation and development of diabetic retinopathy. Keywords: diabetes mellitus, diabetic retinopathy, pentraxin‑3.

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Taurine: a promising nutraceutic in the prevention of retinal degeneration

García‐Ayuso

Pierdomenico

Martínez-Vacas

et al. 2023

Neural Regeneration Research

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Taurine is considered a non-essential amino acid because it is synthesized by most mammals. However, dietary intake of taurine may be necessary to achieve the physiological levels required for the development, maintenance, and function of certain tissues. Taurine may be especially important for the retina. The concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress, apoptosis, and degeneration of photoreceptors and retinal ganglion cells. Low plasma taurine levels may also underlie retinal degeneration in humans and therefore, taurine administration could exert retinal neuroprotective effects. Taurine has antioxidant, anti-apoptotic, immunomodulatory, and calcium homeostasis-regulatory properties. This review summarizes the role of taurine in retinal health and disease, where it appears that taurine may be a promising nutraceutical.

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New Insights into Diabetic and Vision-Threatening Retinopathy: Importance of Plasma Long Pentraxine 3 and Taurine Levels

Cited by 3 publications

References 26 publications

The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy

The Long Pentraxin PTX3 as a New Biomarker and Pharmacological Target in Age-Related Macular Degeneration and Diabetic Retinopathy

Assessment of serum Pentraxin3 level in Iraq patients with and without Diabetic Retinopathy

Taurine: a promising nutraceutic in the prevention of retinal degeneration

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