New insights into eutectic cream skin penetration enhancement

Fiala, Sarah; Roman, Marie; Inacio, Ricardo; Mashal, Sumaia; Brown, Marc; Jones, Stuart A.

doi:10.1016/j.ijpharm.2015.12.059

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Reid et al [52] showed that EtOH/PEG HFA spray could generate a 6-fold enhancement of BMV delivery through the skin as compared to commercial cream, but not one approach works for all systems. For example, Fiala et al [53] used a similar approach to Reid et al [47] when trying to improve the skin penetration of lidocaine, but this was not successful. It should be noted that although HPMC did not show the ability to hider the delivery of the aggregated tetracaine in the current study viscosity modifiers do generally have the potential to hinder drug diffusion from the formulation into the skin.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Potential for Drug–Nanoparticle Surface Interactions To Improve Drug Penetration into the Skin

et al. 2016

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There is continued debate as to how nanomaterials enhance the passive diffusion of drugs through the skin. This study examined if drug-nanoparticle surface interactions, which occurred during topical application, had the capability to enhance percutaneous penetration. Atomic force microscopy force adhesion measurements were used to demonstrate that a model drug, tetracaine, strongly adsorbed to the surface of a negatively charged carboxyl-modified polystyrene nanoparticle (NanoPSCOOH) through both its methyl and amine functionalities (up to a 6- and 16-fold greater adhesion force respectively compared with the CH3-CH3 control). These drug-particle adhesion forces were significantly reduced (p < 0.05) to values that were lower than the CH3-CH3 control measurements when tetracaine interacted with a silica nanoparticle (NanoSiO2). This reduction in adhesion was attributed to the lower surface charge of the NanoSiO2 (ca. -23 mV) compared to the NanoPSCOOH (ca. -40 mV), which diminished the electrostatic interactions between positive amine of tetracaine and the negative particle. Mixing NanoPSCOOH with tetracaine on the skin retarded percutaneous drug penetration compared to the control (tetracaine saturated solution without nanoparticles), but the NanoSiO2, which still adsorbed the tetracaine, produced a 3.6-fold enhancement in percutaneous penetration compared to the same control. These data demonstrated the capability of moderate nanoparticle surface interactions that occurred within the application vehicle to promote drug percutaneous penetration.

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Section: Discussionmentioning

confidence: 99%