New insights into mechanisms of Alzheimer’s disease revealed by a dynamic functional magnetic resonance imaging study

Long, Yicheng

doi:10.21037/atm-21-743

Cited by 1 publication

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“…Briefly, it includes removing the first 10 volumes, slice timing, motion realignment, spatial normalization, temporal filtering (0.01–0.10 Hz), and regressing out for the white matter, cerebrospinal fluid and global mean signals. We performed global signal regression (GSR) here based on the suggestion that GSR is important to diminish motion artifacts in dynamic FC analyses ( 48 , 49 ). All acquired images was manually checked by trained researchers after preprocessing to ensure the quality.…”

Section: Methodsmentioning

confidence: 99%

Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

Huang

Liu

et al. 2021

Front. Psychiatry

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Betel quid (BQ) is one of the most popular addictive substances in the world. However, the neurophysiological mechanism underlying BQ addiction remains unclear. This study aimed to investigate whether and how BQ chewing would affect brain function in the framework of a dynamic brain network model. Resting-state functional magnetic resonance imaging scans were collected from 24 male BQ-dependent individuals and 26 male non-addictive healthy individuals before and promptly after chewing BQ. Switching rate, a measure of temporal stability of functional brain networks, was calculated at both global and local levels for each scan. The results showed that BQ-dependent and healthy groups did not significantly differ on switching rate before BQ chewing (F = 0.784, p = 0.381, analysis of covariance controlling for age, education, and head motion). After chewing BQ, both BQ-dependent (t = 2.674, p = 0.014, paired t-test) and healthy (t = 2.313, p = 0.029, paired t-test) individuals showed a significantly increased global switching rate compared to those before chewing BQ. Significant corresponding local-level effects were observed within the occipital areas for both groups, and within the cingulo-opercular, fronto-parietal, and cerebellum regions for BQ-dependent individuals. Moreover, in BQ-dependent individuals, switching rate was significantly correlated with the severity of BQ addiction assessed by the Betel Quid Dependence Scale scores (Spearman's rho = 0.471, p = 0.020) before BQ chewing. Our study provides preliminary evidence for the acute effects of BQ chewing on brain functional dynamism. These findings may provide insights into the neural mechanisms of substance addictions.

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Section: Methodsmentioning

confidence: 99%

Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

Huang

Liu

et al. 2021

Front. Psychiatry

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New insights into mechanisms of Alzheimer’s disease revealed by a dynamic functional magnetic resonance imaging study

Abstract: et al. Temporal dynamic changes of intrinsic brain activity in Alzheimer's disease and mild cognitive impairment patients: a resting-state functional magnetic resonance imaging study. Ann Transl Med 2021;9:63.

Cited by 1 publication

References 10 publications

Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

Acute Effect of Betel Quid Chewing on Brain Network Dynamics: A Resting-State Functional Magnetic Resonance Imaging Study

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