New insights into molecular diagnostic pathology of primary liver cancer: Advances and challenges

Wang, Cong; Wu, Mengchao

doi:10.1016/j.canlet.2015.07.043

Cited by 34 publications

(27 citation statements)

References 56 publications

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“…Based on a multicenter clinical retrospective study, the 8th Edition of the American Joint Committee on Cancer Staging Manual no longer discusses the prognostic impact of MVI on this type of HCC . However, with the standardization of the sampling protocol and the refinement of MVI classification, MVI is still an essential biological behavior parameter in the pathological diagnosis of HCC . An increasing number of studies have confirmed that MVI is a key factor leading to early recurrence and a poor prognosis of HCC .…”

Section: Discussionmentioning

confidence: 99%

“…8 However, with the standardization of the sampling protocol and the refinement of MVI classification, MVI is still an essential biological behavior parameter in the pathological diagnosis of HCC. 19,23 An increasing number of studies have confirmed that MVI is a key factor leading to early recurrence and a poor prognosis of HCC. 12 Therefore, a growing number of studies are devoted to the preoperative prediction of MVI.…”

Section: Discussionmentioning

confidence: 99%

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Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Wang

2018

Hepatology Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Wang

2018

Hepatology Research

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“…HepPar‐1, Ki‐67, CK7, and CK19 were analyzed to explore the molecular features in these ICC tissues. These markers are not expressed in normal liver tissues and can be used to differentiate feverish patients with ICC from those with benign disease . The histochemical expression of HepPar‐1, CK7, and CK19 was similar in patients with ICC with and without fever.…”

Section: Discussionmentioning

confidence: 98%

Clinical Characteristics and Prognostic Factors of Patients with Intrahepatic Cholangiocarcinoma with Fever: A Propensity Score Matching Analysis

et al. 2019

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Background Patients with intrahepatic cholangiocarcinoma (ICC) rarely present fever as the initial symptom. We aimed to identify clinical characteristics and prognostic factors for these feverish patients. Subjects, Materials, and Methods This study retrospectively reviewed 31 patients with ICC with fever (≥38.0°C) treated at our hospital between January 2002 and December 2014. A propensity score was used to match patients with and without fever at a ratio of 1:2. Results Patients with ICC with fever had higher serum γ‐glutamyl transferase and carcinoembryonic antigen levels, larger tumors, poorer tumor differentiation, and worse prognosis (all p < .05) than those without fever. This was supported by propensity score matching (PSM) analysis. Univariate and multivariate analyses indicated that microvascular invasion, hilar lymph node metastasis, and temperature ≥ 38.6°C were related to prognosis. Patients with ICC with fever had higher levels of leucocytes, neutrophils, neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) in peripheral blood before and after PSM analysis. Body temperature positively correlated with leucocytes (r = 0.599, p < .001), neutrophils (r = 0.644, p < .001), NLR (r = 0.681, p < .001), and PLR (r = 0.457, p = .010). Conclusion Patients with ICC with fever ≥38.0°C and ≥38.6°C had poor and extremely poor prognosis, respectively. Radical surgical treatment may improve the prognosis of patients with ICC with fever <38.6°C. However, systemic therapy (e.g., anti‐inflammatory and immune therapy) may be preferable to surgery for these patients with fever ≥38.6°C. Implications for Practice Patients with intrahepatic cholangiocarcinoma (ICC) with fever (≥38.0°C) as the initial symptom are extremely rare. Because their symptoms are similar to those of liver abscess, diagnosis is challenging, and most of these patients are already at an advanced stage at the time of diagnosis. Patients with ICC with fever had different clinical characteristics and worse prognosis than those without fever. The prognosis of those with temperature <38.6°C would be improved by timely surgical intervention. Those with fever ≥38.6°C had an extremely dismal outcome, although they all received radical surgical treatment. New therapeutic strategies are needed to improve survival for patients with ICC with temperature ≥38.6°C.

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“…Early diagnosis and early treatment of primary hepatocellular carcinoma have proved to deliver more remarkable overall effect (Cong & Wu, ). Surgical resection is effective to a certain extent.…”

Section: Introductionmentioning

confidence: 99%

Post-operative care of interventional therapy for 40 liver cancer patients with obstructive jaundice

Tong

Chen

et al. 2018

Eur J Cancer Care

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The care of 40 patients with primary liver cancer with obstructive jaundice treated with liver puncture bile drainage or biliary stent implantation was reported. Treated with the interventional therapy, patients were observed closely to identify symptoms of hepatic encephalopathy and pain; diet care was well performed. Bile drainage tube and skin acre were performed carefully. Liver function, bilirubin and other biochemical indicators were monitored; occurrence of bleeding, acute pancreatitis, biliary tract infection, leakage of ascites around drainage tube and other complication were observed with good discharge instruction. After this operation, three rounds of liver had poor function, and hepatic encephalopathy and death occurred during hospitalisation. Seven patients had bloody bile drainage fluid after operation; eight had increased blood amylase; nine had biliary infection and four had leakage of ascites around the drainage tube. After positive treatment and care, the situation was improved with varied degrees of jaundice increase.

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New insights into molecular diagnostic pathology of primary liver cancer: Advances and challenges

Cited by 34 publications

References 56 publications

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Clinical Characteristics and Prognostic Factors of Patients with Intrahepatic Cholangiocarcinoma with Fever: A Propensity Score Matching Analysis

Post-operative care of interventional therapy for 40 liver cancer patients with obstructive jaundice

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