New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders

Clara, Villa; Paudel, Yam Nath; Piperi, Christina

doi:10.3390/brainsci12091190

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…QUE is an antagonist of TLR4 receptors, expressed by neurons to produce pro‐inflammatory mediators such as interferons, cytokines and chemokines that activate and recruit glial cells to participate in neuronal cell death by apoptosis 77 . CNS TLR receptors 1–9 are expressed in neurons and microglial cells in both humans and mice, 78 and TLR 2–4, 7 and 9 are known to play a role in PD, thus also being targets of interest 76,79 …”

Section: Discussionmentioning

confidence: 99%

“…77 CNS TLR receptors 1-9 are expressed in neurons and microglial cells in both humans and mice, 78 and TLR 2-4, 7 and 9 are known to play a role in PD, thus also being targets of interest. 76,79 QUE was also reported to worsen PD symptoms under certain conditions, as loss of dopaminergic neurons and PD symptoms were aggravated in a LC-induced PD model. 80 This was due to the inhibitory effect of QUE on the expression of HSP70, decreasing it by 58% in dopaminergic neurons of the compact zone of the substantia nigra, leading to proteotoxic cellular stress and low levels of dopamine, TH and VMAT.…”

Section: Molecular Mechanisms Of Action Of Que In Pdmentioning

confidence: 99%

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Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

de Oliveira Vian,

Marinho,

da Silva Marques

et al. 2024

Basic Clin Pharma Tox

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Parkinson's disease (PD) is a neurodegenerative disease that affects dopaminergic neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and neuroprotective properties that are promising for the treatment of PD. This systematic review aimed to investigate the therapeutic effects of QUE against PD in preclinical models. The systematic search was performed in PubMed, Scopus and Web of Science. At the final screening stage, 26 articles were selected according to pre‐established criteria. Selected studies used different methods for PD induction, as well as animal models. Most studies used rats (73.08%) and mice (23.08%), with 6‐OHDA as the main strategy for PD induction (38.6%), followed by rotenone (30.8%). QUE was tested immersed in oil, nanosystems or in free formulations, in varied routes of administration and doses, ranging from 10 to 400 mg/kg and from 5 to 200 mg/kg in oral and intraperitoneal administrations, respectively. Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Molecular Mechanisms Of Action Of Que In Pdmentioning

confidence: 99%

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

de Oliveira Vian,

Marinho,

da Silva Marques

et al. 2024

Basic Clin Pharma Tox

View full text Add to dashboard Cite

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Insights into Dysregulated Neurological Biomarkers in Cancer

Duranti,

Villa

2024

Cancers

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The link between neurodegenerative diseases (NDs) and cancer has generated greater interest in biomedical research, with decades of global studies investigating neurodegenerative biomarkers in cancer to better understand possible connections. Tau, amyloid-β, α-synuclein, SOD1, TDP-43, and other proteins associated with nervous system diseases have also been identified in various types of solid and malignant tumors, suggesting a potential overlap in pathological processes. In this review, we aim to provide an overview of current evidence on the role of these proteins in cancer, specifically examining their effects on cell proliferation, apoptosis, chemoresistance, and tumor progression. Additionally, we discuss the diagnostic and therapeutic implications of this interconnection, emphasizing the importance of further research to completely comprehend the clinical implications of these proteins in tumors. Finally, we explore the challenges and opportunities in targeting these proteins for the development of new targeted anticancer therapies, providing insight into how to integrate knowledge of NDs in oncology research.

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New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders

Abstract: Neurodegenerative disorders remain a major burden for our society, affecting millions of people worldwide [...]

Cited by 2 publications

References 12 publications

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

Effects of quercetin in preclinical models of Parkinson's disease: A systematic review

Insights into Dysregulated Neurological Biomarkers in Cancer

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