New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Joshi, Atul

doi:10.3389/fendo.2020.00172

Cited by 51 publications

(42 citation statements)

References 79 publications

(134 reference statements)

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“…Previous studies have established the involvement of these six immune-related genes in invasion and metastasis of HNSCC tumor cells. More recently, both PLAU and STC2 were identified as oncogenes in HNSCC tumors, associated with immunosuppression and inflammation (Chang et al, 2003;Ieta et al, 2009;Na et al, 2015;Yang et al, 2017Yang et al, , 2020Joshi, 2020;Fang et al, 2021;Li et al, 2021). TNFRSF4 (also known as CD134/ OX40) is one of the representative targets of second-generation immune checkpoints, and its clinical efficacy has been observed by anti-TNFRSF4 (MEDI6469) therapy in HNSCC patients through regulating antigen-specific tumorinfiltrating T cells (Duhen et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

et al. 2021

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The immune response within the tumor microenvironment plays a key role in tumorigenesis and determines the clinical outcomes of head and neck squamous cell carcinoma (HNSCC). However, to date, very limited robust and reliable immunological biomarkers have been developed that are capable of estimating prognosis in HNSCC patients. In this study, we aimed to identify the effects of novel immune-related gene signatures (IRGs) that can predict HNSCC prognosis. Based on gene expression profiles and clinical data of HNSCC patient cohorts from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, a total of 439 highly variable expressed immune-related genes (including 239 upregulated and 200 downregulated genes) were identified by using differential gene expression analysis. Pathway enrichment analysis indicated that these immune-related differentially expressed genes were enriched in inflammatory functions. After process screening in the training TCGA cohort, six immune-related genes (PLAU, STC2, TNFRSF4, PDGFA, DKK1, and CHGB) were significantly associated with overall survival (OS) based on the LASSO Cox regression model. Integrating these genes with clinicopathological features, a multivariable model was built and suggested better performance in determining patients’ OS in the testing cohort, and the independent validation cohort. In conclusion, a well-established model encompassing both immune-related gene signatures and clinicopathological factors would serve as a promising tool for the prognostic prediction of HNSCC.

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Section: Discussionmentioning

confidence: 99%

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

et al. 2021

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“…At the same time, Huang et al showed that EXT2 is an independent prognostic factor for hepatocellular carcinoma [ 43 , 43 ]. Stanniocalcin (STC) is a glycosylated peptide hormone involved in calcium and phosphate homeostasis [ 44 ]. Among them, STC2 can regulate glucose homeostasis [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas

Liu

Yin

2020

Journal of Oncology

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Aims. The preferential dependence on glycolysis as a pathway of energy metabolism is a hallmark of cancer cells. However, the prognostic significance of glycolysis-related genes in head and neck squamous cell carcinoma (HNSCC) remains obscure. The purpose of this study was to identify glycolysis-related genes of prognostic value in HNSCC. Results. Transcriptional and clinical data of 544 HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) dataset. By gene set enrichment analysis (GSEA) and by employing a univariate and subsequently a stepwise multivariate Cox proportional regression model, eight glycolysis-related genes of prognostic significance in HNSCC (KIF2A, JMJD8, HMMR, STC2, HK1, EXT2, GPR8, and STC1) were identified. The patients were clustered into two groups (high and low risk) based on the expression of these genes. High-risk patients had significantly a shorter overall survival than low-risk patients. Furthermore, a new prognostic indicator based on selected glycolysis-related genes was developed by multivariate Cox analysis that proved to be a better predictor of patient outcome compared to other clinical factors. Conclusion. Our findings provide new insights into the role of glycolysis in HNSCC. The identified genes predict the patient prognosis and might substantially contribute to the development of individualized treatments.

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“…The lack of spatial conservation of the 11th cysteine residue in STC-2 compared to fish STC/STC-1, combined with the presence of four additional cysteine residues in this protein, leads to the prediction that STC-2 has a different tertiary structure when compared with other STCs. Despite some structural similarities between both STC-1 and STC-2, there is no evidence, thus far, to suggest that these proteins are capable of heterodimerisation ( Joshi, 2020 ). Another defining feature of STC-1, which is also conserved amongst the STCs, is the presence of an N-linked glycosylation consensus sequence (Asn-X-Thr/Ser).…”

Section: Introductionmentioning

confidence: 99%

Stanniocalcin-1 in the female reproductive system and pregnancy

Bishop

Cartwright

Whitley

2021

Human Reproduction Update

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BACKGROUND Stanniocalcin-1 (STC-1) is a widely expressed glycoprotein hormone involved in a diverse spectrum of physiological and pathophysiological processes including angiogenesis, mineral homeostasis, cell proliferation, inflammation and apoptosis. Over the last 20 years, numerous studies have reported STC-1 expression within female reproductive tissues including the uterus, ovaries and placenta and implicated STC-1 in processes such as ovarian follicular development, blastocyst implantation, vascular remodelling in early pregnancy and placental development. Notably, dysregulation of STC-1 within reproductive tissues has been linked to the onset of severe reproductive disorders including endometriosis, polycystic ovary syndrome, poor trophoblast invasion and placental perfusion in early pregnancy. Furthermore, significant changes in tissue expression and in maternal systemic concentration take place throughout pregnancy and further substantiate the vital role of this protein in reproductive health and disease. OBJECTIVE AND RATIONALE Our aim is to provide a comprehensive overview of the existing literature, to summarise the expression profile and roles of STC-1 within the female reproductive system and its associated pathologies. We highlight the gaps in the current knowledge and suggest potential avenues for future research. SEARCH METHODS Relevant studies were identified through searching the PubMed database using the following search terms: ‘stanniocalcin-1’, ‘placenta’, ‘ovary’, ‘endometrium’, ‘pregnancy’, ‘reproduction’, ‘early gestation’. Only English language papers published between 1995 and 2020 were included. OUTCOMES This review provides compelling evidence of the vital function that STC-1 plays within the female reproductive system. The literature presented summarise the wide expression profile of STC-1 within female reproductive organs, as well as highlighting the putative roles of STC-1 in various functions in the reproductive system. Moreover, the observed link between altered STC-1 expression and the onset of various reproductive pathologies is presented, including those in pregnancy whose aetiology occurs in the first trimester. This summary emphasises the requirement for further studies on the mechanisms underlying the regulation of STC-1 expression and function. WIDER IMPLICATIONS STC-1 is a pleiotropic hormone involved in the regulation of a number of important biological functions needed to maintain female reproductive health. There is also growing evidence that dysregulation of STC-1 is implicated in common reproductive and obstetric disorders. Greater understanding of the physiology and biochemistry of STC-1 within the field may therefore identify possible targets for therapeutic intervention and/or diagnosis.

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New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Cited by 51 publications

References 79 publications

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma

A Novel Prognostic Index Based on the Analysis of Glycolysis-Related Genes in Head and Neck Squamous Cell Carcinomas

Stanniocalcin-1 in the female reproductive system and pregnancy

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