New Insights into Potential Beneficial Effects of Bioactive Compounds of Bee Products in Boosting Immunity to Fight COVID-19 Pandemic: Focus on Zinc and Polyphenols

Bakour, Meryem; Laaroussi, Hassan; Ousaaid, Driss; Es-safi, Imane; Mechchate, Hamza; Lyoussi, Badiâa

doi:10.3390/nu14050942

Cited by 6 publications

(6 citation statements)

References 193 publications

(211 reference statements)

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“…71 Generally, the use of natural bioactive compounds (eg, zinc + polyphenols) is subject of current research and might be a promising approach to affect the immune system's response to illness. 72,73 9.3 | Patients on ECMO or cardiac surgery ECMO therapy is proposed to lead to multiple alterations in serum inflammatory markers, as well as in the overall free radical activity, with an associated decreased bioavailability of micronutrient and trace elements. 73,74 Antioxidant supplementation has been proposed to ameliorate this proinflammatory state.…”

Section: Patients With Severe Acute Respiratory Syndrome Coronavirus ...mentioning

confidence: 99%

“…Regarding zinc, a meta‐analysis ( n = 4 studies) including 761 patients receiving zinc supplementation compared with 712 receiving standard care showed a slight increase in the length of ICU stay and no improvement in the overall survival for the study group, suggesting that there is no evidence to support zinc supplementation in hospitalized patients with COVID‐19 71 . Generally, the use of natural bioactive compounds (eg, zinc + polyphenols) is subject of current research and might be a promising approach to affect the immune system's response to illness 72,73 …”

Section: Specific Patient Cohorts At Riskmentioning

confidence: 99%

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Overview of oxidative stress and the role of micronutrients in critical illness

Dresen

Pimiento

Patel

et al. 2022

J Parenter Enteral Nutr

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Inflammation and oxidative stress represent physiological response mechanisms to different types of stimuli and injury during critical illness. Its proper regulation is fundamental to cellular and organismal survival and are paramount to outcomes and recovery from critical illness. A proper maintenance of the delicate balance between inflammation, oxidative stress, and immune response is crucial for resolution from critical illness with important implications for patient outcome. The extent of inflammation and oxidative stress under normal conditions is limited by the antioxidant defense system of the human body, whereas the antioxidant capacity is commonly significantly compromised, and serum levels of micronutrients and vitamins significantly depleted in patients who are critically ill. Hence, the provision of antioxidants and anti-inflammatory nutrients may help to reduce the extent of oxidative stress and therefore improve clinical outcomes in patients who are critically ill. As existing evidence of the beneficial effects of antioxidant supplementation in patients who are critically ill is still unclear, actual findings about the most promising anti-inflammatory and antioxidative candidates selenium, vitamin C, zinc, and vitamin D will be discussed in this narrative review. The existing evidence provided so far demonstrates that several factors need to be considered to determine the efficacy of an antioxidant supplementation strategy in patients who are critically ill and indicates the need for adequately designed multicenter prospective randomized control trials to evaluate the clinical significance of different types and doses of micronutrients and vitamins in selected groups of patients with different types of critical illness.

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Section: Patients With Severe Acute Respiratory Syndrome Coronavirus ...mentioning

confidence: 99%

Section: Specific Patient Cohorts At Riskmentioning

confidence: 99%

Overview of oxidative stress and the role of micronutrients in critical illness

Dresen

Pimiento

Patel

et al. 2022

J Parenter Enteral Nutr

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“…[1,2] Bee products are one of these natural products which are among the crucial complementary treatment option. Several studies demonstrate that bee products exhibit antibacterial, [3] antifungal, [4] antiviral, [5] antiprotozoal, [6] anticancer, [7] features thanks to bioactive compounds they contain. [8] Apitherapy is a significant type of complementary treatment using bee products for both the cure and prevention of various diseases involving diabetic foot ulcers, injuries, rhinitis and rheumatoid arthritis since ancient times.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the bioactivity of bee bread is significantly higher than bee pollen [9] . These properties enable bee bread to become a functional nutrient [5] . However, there is no sufficient study on the bioaccessibility of phenolic compounds of bee bread in human digestive system.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Bioaccessible Phenolic Compounds in Aegean Bee Bread Using LC‐HRMS Coupled with a Human Digestive System Model

Erol

2024

Chemistry & Biodiversity

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Bee bread, a valuable bee product that has recently attracted significant public interest as a nutritional supplement. The aim of this study was to evaluate the presence of phenolic compounds in bee bread samples from the Aegean Region and assess their bioaccessibility using a simulated human digestion model. Various extraction techniques, such as maceration, ultrasound‐assisted extraction, and supercritical fluid extraction were employed to obtain extracts of bee bread. The antioxidant capabilities of these extracts were carried out using assays like DPPH•, ABTS•+, CUPRAC, and β‐carotene linoleic acid bleaching, and their effectiveness was quantified through IC50 values. The bioaccessibility of phenolic compounds was analysed by using LC‐HRMS in a simulated human digestive system using ethanol extracts obtained from bee bread samples of each season by ultrasound‐assisted extraction, which has the highest antioxidant activity. In the Aegean bee bread, a total of 25 phenolic compounds which were major phenolics including quercetin, ascorbic acid, isorhamnetin, kaempferol, and hyperoside were identified and quantified. Also, ascorbic acid was the one of the most bioaccessible compounds with the bioaccessibility index 35.38% for 2021, 16.79% for 2022. These findings underscore the substantial transformation of the phenolic profile of bee bread as it traverses the human digestive system.

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“…Polyphenols of honey and beekeeping products were also studied for their role in strengthening the human immune system, concerning their contribution to the mitigation of COVID symptoms and the reduction of patient recovery periods. Supplementation of honey with standard pharmaceuticals, such as opinavir/ritonavir tablets, arbidol, chloroquine phosphate, hydroxychloroquineoroseltamivir with or without azithromycin, chloroquine or hydroxychloroquine, or oseltamivir corticosteroids showed promising outcomes in various clinical studies [20].…”

Section: Introductionmentioning

confidence: 99%

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

et al. 2023

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Research attention has been drawn to honey’s nutritional status and beneficial properties for human health. This study aimed to provide a bibliometric analysis of honey’s antioxidant and antimicrobial properties. The research advancements within this field from 2001 to 2022 were addressed using the Scopus database, R, and VOSviewer. Of the 383 results, articles (273) and reviews (81) were the most common document types, while the annual growth rate of published manuscripts reached 17.5%. The most relevant topics about honey’s antimicrobial and antioxidant properties were related to the agricultural and biological sciences, biochemistry, and pharmacology. According to a keyword analysis, the most frequent terms in titles, abstracts, and keywords were honey, antimicrobial, antioxidant, bee, propolis, phenolic compounds, wound, antibacterial, anti-inflammatory, and polyphenols. A trend topic analysis showed that the research agenda mainly encompassed antioxidants, pathogens, and anti-infection and chemical agents. In a co-occurrence analysis, antioxidants, anti-infection agents, and chemistry were connected to honey research. The initial research focus of this domain was primarily on honey’s anti-inflammatory and antineoplastic activity, wound healing, and antibacterial agents. The research agenda was enriched in the subsequent years by pathogens, propolis, oxidative stress, and flavonoids. It was possible to pinpoint past trends and ongoing developments and provide a valuable insight into the field of honey research.

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New Insights into Potential Beneficial Effects of Bioactive Compounds of Bee Products in Boosting Immunity to Fight COVID-19 Pandemic: Focus on Zinc and Polyphenols

Cited by 6 publications

References 193 publications

Overview of oxidative stress and the role of micronutrients in critical illness

Overview of oxidative stress and the role of micronutrients in critical illness

Quantitative Analysis of Bioaccessible Phenolic Compounds in Aegean Bee Bread Using LC‐HRMS Coupled with a Human Digestive System Model

Honey’s Antioxidant and Antimicrobial Properties: A Bibliometric Study

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