New insights into precocious puberty and ADHD: a nationwide cohort study

Pai, Li-Fan; Wang, Der-Shiun; Hsu, Wan-Fu; Huang, Shao-Wei; Chung, Chi‐Hsiang; Chen, Shyi-Jou; Chien, Wu-Chien; Chu, Der-Ming

doi:10.1038/s41390-022-02028-5

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…However, it is possible that this link exists because stimulant medication tends to decrease appetite (Waxmonsky, Pelham, Bawjea, et al, 2022), leading to a lower body mass index (Rosenthal & Hinshaw, 2023;Waxmonsky, Pelham, Bawjea, et al, 2022). Pai et al (2022) observed a higher incidence of precocious puberty in boys and girls with ADHD, girls overall, in youth living in more urbanized areas. However, no relation between taking ADHD medication and central precocious puberty (Pai et al, 2022) or sexual development within the ADHD cohort emerged.…”

Section: Puberty Psychopathology and Adhdmentioning

confidence: 88%

“…Pai et al (2022) observed a higher incidence of precocious puberty in boys and girls with ADHD, girls overall, in youth living in more urbanized areas. However, no relation between taking ADHD medication and central precocious puberty (Pai et al, 2022) or sexual development within the ADHD cohort emerged. Currently, knowledge of the association between pubertal timing, early ADHD symptoms, and later comorbid symptoms is limited.…”

Section: Puberty Psychopathology and Adhdmentioning

confidence: 88%

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Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood

Mlodnicka,

Mansolf,

Chandran

et al. 2024

Dev Psychopathol

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Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data (n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11.9 years). Within a subsample age at peak height velocity (APHV) acted as a proxy to assess pubertal timing from early childhood (mean age = 5.4 years) to adolescence (mean age = 12.3 years). Early-childhood ADHD symptoms predicted later psychiatric symptoms, including anxiety, depression, aggressive behavior, conduct problems, oppositional defiant disorder, and rule-breaking behavior. Earlier APHV was associated with increased Conduct Disorder symptoms from late childhood to adolescence for females only. A stronger relation between ADHD symptoms and later aggression was observed in females with earlier APHV, whereas this same pattern with aggression, conduct problems and depression was observed in males with later APHV. Clinicians should consider that both young girls and boys with elevated ADHD symptoms, particularly with off-set pubertal timing, may be at risk for later psychiatric symptoms.

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Section: Puberty Psychopathology and Adhdmentioning

confidence: 88%

Section: Puberty Psychopathology and Adhdmentioning

confidence: 88%

Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood

Mlodnicka,

Mansolf,

Chandran

et al. 2024

Dev Psychopathol

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“…The exclusion criteria for the study were other organic factors that may contribute to precocious puberty based on previous studies [21,29] included the following: primary hypothyroidism, central nervous system infection, congenital abnormalities of the central nervous system, septo-optic dysplasia, tuberous sclerosis, Sturge-Weber syndrome, and ever radiation to the central nervous system. Individuals with these diseases were excluded.…”

Section: Study Populationmentioning

confidence: 99%

“…First, Geier et al did not address the influence of the neuropsychiatric comorbidities. Some comorbidities such as ADHD and epilepsy have been reported to be associated with the risk of precocious puberty [21][22][23]. These comorbidities are often comorbid with ASD with a complex etiology [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Association between Autism Spectrum Disorder and Precocious Puberty: Considering the Effect Modification by Sex and the Neuropsychiatric Comorbidities

Liu,

Liao,

Wen

et al. 2024

Preprint

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Limited knowledge is available about the association between autistic spectrum disorder (ASD) and precocious puberty. Our study examined the association between the two medical conditions, and the effect modification by sex and neuropsychiatric comorbidities in a nationwide population. To compare the risk of precocious puberty between ASD and non-ASD cases, we conducted Cox regression analysis, using ASD as exposure and time-to-precocious puberty as outcome. We adjusted for sex, attention-deficit/hyperactivity disorder (ADHD), tics disorder, obsessive–compulsive disorder (OCD), anxiety disorder, intellectual disability, and epilepsy. We performed a moderation analysis to examine the potential moderating effects by sex or comorbidities. Patients with ASD were prone to have precocious puberty, with an adjusted hazard ratio (aHR) of 1.80 (95% CI: 1.61-2.01). For the effect modification, sex, specifically females, moderated the association between ASD and precocious puberty, with relative excess risk due to interaction (RERI) 7.35 (95% CI 4.90-9.80). No significant effect modification was found for any of the comorbidities within the scope of additive effect modification. We found that patients with ASD were prone to precocious puberty, regardless of sex or comorbid neuropsychiatric disorders. Girls with ASD are at particularly higher risk to develop precocious puberty.

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“…Kim & Lee, 2012). A recent population-based retrospective cohort study showed higher risk of central precocious puberty in children with ADHD (Pai et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Attention Deficit Hyperactivity Disorder in Girls With Central Precocious Puberty

Lee

et al. 2023

J Atten Disord

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Objective: The purpose of the current study was to examine the prevalence of attention deficit hyperactivity disorder (ADHD) in girls with central precocious puberty. Method: Girls with central precocious puberty were prospectively recruited from the pediatric clinic. Screening was done with ADHD Rating Scale (ADHD-RS) and Child Behavior Checklist (CBCL). Those who screened positive on ADHD-RS were referred for the diagnostic evaluation which included a Computerized Performance Test (CPT) and a clinical interview conducted by a child adolescent psychiatrist. Results: Among the 81 girls (mean age = 8.97 ± 0.91) who completed the study, 11 girls (13.58%) were diagnosed with ADHD: 5 of them were inattentive type and 6 of them were combined type. Conclusion: The present exploratory study showed that the prevalence of ADHD in girls with central precocious was higher than the known worldwide prevalence of ADHD in children

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New insights into precocious puberty and ADHD: a nationwide cohort study

Cited by 9 publications

References 37 publications

Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood

Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood

The Association between Autism Spectrum Disorder and Precocious Puberty: Considering the Effect Modification by Sex and the Neuropsychiatric Comorbidities

Prevalence of Attention Deficit Hyperactivity Disorder in Girls With Central Precocious Puberty

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