New insights into quercetin nanoformulations for topical delivery

Wadhwa, Karan; Kadian, Varsha; Puri, Vivek; Bhardwaj, Bigul Yogeshvar; Sharma, Ameya; Pahwa, Rakesh; Rao, Rekha; Gupta, Madhu; Singh, Inderbir

doi:10.1016/j.phyplu.2022.100257

Cited by 83 publications

(36 citation statements)

References 112 publications

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“…A non-polar group in its structure and a polar hydroxyl group can also block quercetin's penetration into the skin [8]. Regardless of its many pharmacological effects on the skin, low hydrophilicity and poor percutaneous absorption are significant limitations to the conventional topical delivery of quercetin [9]. Due to its problem of penetrating the skin, numerous methods have been developed and investigated that increase the skin penetration capacity of quercetin.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Chrismaurin

DWIASTUTI²,

Chabib³

et al. 2023

Int J App Pharm

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Objective: This research aims to evaluate the effect of olive oil, tween 60, and span 20 on the physical properties of quercetin nanoemulgel. Methods: In this research, quercetin was formulated into nanoemulgel using a variation of olive oil, tween 60, span 20, and sodium alginate as a gelling agent. The nanoemulgel physical properties (pH, viscosity, and spreadability), stability, and particle size were tested. The data were measured and evaluated using Minitab®18 software; if the p-value<0.05, it is stated that there is a statistically significant difference in the formula. Results: The result showed that tween 60 has the greatest significant impact on pH, viscosity, and transmittance value with a p-value<0.05 for all, meanwhile span 20 has the greatest significant impact on the spreadability of the nanoemulgel preparations with a p-value<0.05 indicating that they are significantly different. Conclusion: This study reported that the effect of olive oil, tween 60 and span 20, with different variations, significantly impacts the physical properties (pH, viscosity, and spreadability) of the nanoemulgel.

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Section: Introductionmentioning

confidence: 99%

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Chrismaurin

DWIASTUTI²,

Chabib³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Additionally, it has immunomodulatory, anti-viral, anti-inflammatory, anti-cancer, anti-tumor, anti-allergy, anti-ulcer, and anti-cancer characteristics ( 8 ). One of the most significant endogenous antioxidants due to its protective nature against oxidants and inflammation, quercetin is widely used in pharmaceutical, cosmetic, and nutraceutical products ( 9 ). Quercetin has strong antioxidant, antibacterial, and anticancer properties, making it useful in a range of pharmaceutical and dietary applications ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

et al. 2022

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Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, and wound-healing properties. Anticancer activity of quercetin against cancer cell lines has also recently been revealed. The majority of the Western diet contains quercetin and its derivatives, therefore consuming them as part of a meal or as a food supplement may be sufficient for people to take advantage of their preventive effects. Bioavailability-based drug-delivery systems of quercetin have been heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, and other plants all contain quercetin, as do natural colors. One naturally occurring antioxidant is quercetin, whose anticancer effects have been discussed in detail. It has several properties that could make it an effective anti-cancer agent. Numerous researches have shown that quercetin plays a substantial part in the suppression of cancer cells in the breast, colon, prostate, ovary, endometrial, and lung tumors. The current study includes a concise explanation of quercetin's action mechanism and potential health applications.

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“…GA is a phenolic acid compound with a simple structure, containing only one benzene ring, which leads to poor stability and rapid decomposition; this is a major challenge in bioavailability [ 12 ]. However, Qu is a highly hydrophobic compound, which limits its applications in the biomedical field [ 16 ]. To overcome the poor in vivo stability and low bioavailability of GA and Qu, topical delivery has been developed as an advanced alternative strategy in recent years; however, the stratum corneum prevents ingress of microorganisms and other exogenous compounds, including many drugs.…”

Section: Introductionmentioning

confidence: 99%

The Treatment of Keloid Scars via Modulating Heterogeneous Gelatin-Structured Composite Microneedles to Control Transdermal Dual-Drug Release

et al. 2022

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Keloid scarring is an abnormal scar disease characterised by excessive proliferation of fibroblasts and over-deposition of collagen during wound healing. Although various treatments for keloid scars have been developed, preventive medicine is believed to be a promising strategy. The skin barrier limits the gentle topical administration of medicaments such as creams and hydrogel dressings, resulting in reduced therapeutic efficacy. In recent years, microneedles (MNs) have been regarded as an appreciable device for topical administration without inducing side effects, and they are painless and do not cause bleeding. In this study, an MN patch with controlled transdermal dual-drug release was developed to achieve combinatory treatment of keloid scars using a heterogeneous gelatin-structured composite MN. Gelatin hydrogel was used as a substrate to load gallic acid (GA) and quercetin-loaded amphiphilic gelatin nanoparticles to fabricate dual-drug heterogeneous composite MNs. The results of the insertion test and mechanical properties of the MNs showed that the heterogeneous composite MN patches could be self-pressed into the stratum corneum and control dual-drug release at different time periods. GA was released at an earlier stage to retard the proliferation of fibroblasts, and quercetin was released at a later stage as a strong antioxidant to erase the generation of reactive oxygen species. Furthermore, real-time quantitative polymerase chain reaction data indicated that the gene expression of fibroblasts (such as Col I and III) was downregulated in the dual-drug system. The above results demonstrate that using heterogeneous composite MNs with the combination of dual-drug pharmacology is beneficial for preventing keloid scar formation.

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New insights into quercetin nanoformulations for topical delivery

Cited by 83 publications

References 112 publications

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

The Effect of Olive Oil, Tween 60 and Span 20 on Physical Characteristics of Quercetin Nanoemulgel

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

The Treatment of Keloid Scars via Modulating Heterogeneous Gelatin-Structured Composite Microneedles to Control Transdermal Dual-Drug Release

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