New insights into redox-related risk factors and therapeutic targets in oral squamous cell carcinoma

Dewenter, Ina; Kumbrink, Joerg; Poxleitner, Philipp; Smolka, Wenko; Liokatis, Paris; Fliefel, Riham; Otto, Sven; Obermeier, Katharina Theresa

doi:10.1016/j.oraloncology.2023.106573

Oral Oncology

2023

DOI: 10.1016/j.oraloncology.2023.106573

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New insights into redox-related risk factors and therapeutic targets in oral squamous cell carcinoma

Ina Dewenter,

Joerg Kumbrink,

Philipp Poxleitner

et al.

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2024

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Cited by 5 publications

References 112 publications

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Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

Lai,

Liu

2024

Oral Oncology Reports

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Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

Lai,

Liu

2024

Oral Oncology Reports

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Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

Anahas,

Ganapathy

2024

Oral Oncology Reports

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PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells

Luo,

Hu,

Tang

et al. 2024

CCDT

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Background: Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in the head and neck. Elucidating molecular mechanisms underlying OSCC occurrence and development is important for the therapy. Dysregulated palmitoylation-related enzymes have been reported in several cancers but OSCC. Objective: To explore the role of palmitoyl protein thioesterase 1 (PPT1) in OSCC. Methods: Differentially Expressed Genes (DEGs) and related protein-protein interaction networks between normal oral epithelial and OSCC tissues were screened and constructed via different online databases. Tumor samples from 70 OSCC patients were evaluated for the relationship between PPT1 expression level and patients’clinic characteristics. The role of PPT1 in OSCC proliferation and metastasis was studied by functional experiments, including MTT, colony formation, EdU incorporation and transwell assays. Lentivirus-based constructs were used to manipulate the gene expression. FerroOrange probe and malondialdehyde assay were used to determine ferroptosis. Growth of OSCC cells in vivo was investigated by a xenograft mouse model. Results: A total of 555 DEGs were obtained, and topological analysis revealed that the PPT1 and GPX4 might play critical roles in OSCC. Increased PPT1 expression was found to be correlated with poor prognosis of OSCC patients. PPT1 effectively promoted the proliferation, migration and invasion while inhibiting the ferroptosis of OSCC cells. PPT1 affected the expression of glutathione peroxidase 4 (GPX4). conclusion: PPT1 inhibits ferroptosis and promotes the growth of OSCC cells. PPT1 may be a potential therapeutic target for OSCC.

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New insights into redox-related risk factors and therapeutic targets in oral squamous cell carcinoma

Cited by 5 publications

References 112 publications

Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments”

PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells

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