New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation

Hejazi, Iram Iqbal; Khanam, Rashmin; Mehdi, Syed Hassan; Bhat, Abdul Roouf; Rizvi, M. Moshahid Alam; Islam, Asimul; Thakur, Sonu Chand; Athar, Fareeda

doi:10.1016/j.biopha.2017.06.108

Cited by 32 publications

(18 citation statements)

References 32 publications

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“…One study by Hejazi et al demonstrated that G glabra enhanced the ROS scavenging effects of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase. 43 In addition, G glabra reduced nitrogen radicals and enhanced mitochondrial function during cellular metabolism abating the initial production of free radicals. 20 , 44 Because of its ability to lower ROS, G glabra can decrease the total level of oxidative stress, which indirectly impedes cortisol release .…”

Section: Discussionmentioning

confidence: 99%

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Martin

Reshamwala

Short

2018

Journal of Chiropractic Medicine

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Objective: The purpose of this case report is to describe the treatment of a patient with acute sinusitis using Glycyrrhiza glabra. Clinical Features: A 26-year-old woman presented with acute sinusitis of 10-day duration. Her symptoms included facial pressure and soreness around the frontal and maxillary sinuses, a headache, pharyngitis, a fever, rhinorrhea, nasal congestion with postnasal drip, a productive cough, myalgias, and fatigue. Intervention and Outcome: After administration of 12 to 15 drops of a 2 000-mg tincture of G glabra twice a day, improvements were noted. Resolution of her symptoms occurred after 3 days of treatment. Conclusion: For the treatment of acute sinusitis, G glabra may be a natural therapeutic remedy. (J Chiropr Med 2018;17:268-274)

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Section: Discussionmentioning

confidence: 99%

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Martin

Reshamwala

Short

2018

Journal of Chiropractic Medicine

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“…However, antibacterial effects ( 44 – 46 ), antifungal ( 47 , 48 ), and antioxidant ( 49 ) of this plant have been evaluated and shown to be positive. Licorice also has showed anti-viral ( 50 ), antibacterial ( 51 ), antifungal ( 52 ), anti-oxidant ( 53 ), anti-inflammatory ( 54 , 55 ) and immune enhancer ( 56 ) effects in various research but based on the studied articles, it hasn’t been used directly in the treatment of chronic sinusitis. In addition to the above mentioned findings about the effectiveness of the plants used in the current trial, teachings in Persian Medicine Literature also reveals significant effects in justifying its usage for rhinosinusitis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the therapeutic effect of the Persian Medicine Protocol with the common treatment of chronic rhinosinusitis: a randomized clinical trial

et al. 2018

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BackgroundChronic rhinosinusitis is one of the most common diseases affecting the quality of life of patients. Patients suffer from high costs in the diagnosis and treatment of the disease. Frequent recurrence and failure of therapeutic protocols are among the most important issues in the management of this disease. In view of this, the use of traditional and complementary therapies to promote the treatment of this disease has been increasingly taken into account.ObjectiveComparison of the effectiveness of the Persian Medicine Protocol with the conventional therapy in the treatment of chronic rhinosinusitis.MethodsA randomized clinical trial was conducted at Imam Reza Hospital in Mashhad, Iran from July 2016 to March 2017. For patients with chronic rhinosinusitis symptoms, endoscopy of the sinuses was performed by an ENT specialist and in the case of negative endoscopy, paranasal sinus CT scan was requested. A total of 42 patients with chronic rhinosinusitis were randomly assigned to two groups. The first group (classical) received systemic and intranasal cortisone, and the second group (traditional) received a therapeutic Persian medicine protocol including intranasal lavender oil, and Liquorice Marjoram Tea (L. M. tea) for six weeks. The symptoms of the patients were evaluated using the SNOT-22 questionnaire at the beginning of the study and at the sixth week. If no improvement occurs, treatment continued for 12 weeks. Data were analyzed by SPSS version 16, using ANOVA, independent-samples and paired-samples t-test, Wilcoxon signed-rank test, and simple linear regression.ResultsIn 20 patients in the traditional group, the decrease in SNOT score was observed as 56% after 6 weeks treatment (p=0.001), which is similar to the effect of the first group (classical). Although there was no statically significant difference between the two groups, in clinical terms, the difference in mean systemic symptoms such as confusion with 1.05 (p=0.5) and fatigue with 1.63 (p=0.01) had more improvement in the traditional group, and the difference in mean local symptoms such as nasal congestion with 2.37 (p=0.78) and runny nose with 1.95 (p=0.14) had a more decrease in the classical group.ConclusionThe results of this trial indicate the effectiveness of the Persian Medicine Protocol (including Lavender oil and L.M tea) in the treatment of chronic rhinosinusitis, especially on improving systemic symptoms. Nevertheless more clinical studies are necessary to support the acquired results.Trial registrationThis trial was registered at the Iranian Center for Clinical Trials (ID: IRCT2015112425217N1).FundingThis research is part of a PhD thesis and is funded by the Vice-Chancellor for Research at Mashhad University of Medical Sciences, Grant No. 931673.

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“…TCM theory holds that the deficiency of vital qi, phlegm, and blood stasis are the main pathogenesis of lung cancer, and ZSD possesses the function of strengthening the spleen and lung to remove phlegm and promote blood circulation to remove stasis. Modern pharmacological studies indicate that both salvia and glycyrrhiza show potent anticancer and antioxidative activities both in vitro and in vivo with representative components [8][9][10]. Furthermore, our previous study found that Huoxue Yiqi recipe 2, which consists of salvia, glycyrrhiza, and panax ginseng, played an antilung cancer effect [11].…”

Section: Introductionmentioning

confidence: 99%

Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK‐3β/β‐Catenin Pathway

Liu

Teng

et al. 2021

Oxidative Medicine and Cellular Longevity

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Lung cancer has become the leading cause of cancer-related death worldwide. Oxidative stress plays important roles in the pathogenesis of lung cancer. Many natural products show antioxidative activities in cancer treatment. Zi Shen decoction (ZSD) is a classic prescription for the treatment of lung disease. However, its effect on lung cancer lacks evidence-based efficacy. In this study, we investigated the anticancer effects of ZSD on lung cancer in vivo and in vitro. Our results showed that oral administration of ZSD suppressed the Lewis lung cancer (LLC) growth in a subcutaneous allograft model and promoted necrosis and inflammatory cell infiltration in the tumor tissues. Furthermore, ZSD not only inhibited tumor cell proliferation and migration but also induced cell apoptosis in lung cancer cells. PI3K/AKT signaling is well characterized in response to oxidative stress. The bioinformatics analysis and western blot assays suggested that ZSD decreased the enzyme activity of PI3K and AKT in vivo and in vitro. We also found that the AKT/GSK-3β/β-catenin pathway medicated anticancer effect of ZSD in lung cancer cells. In conclusion, we demonstrate for the first time that ZSD possesses antitumor properties, highlighting its potential use as an alternative strategy or adjuvant treatment for lung cancer therapy.

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New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation

Cited by 32 publications

References 32 publications

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Comparison of the therapeutic effect of the Persian Medicine Protocol with the common treatment of chronic rhinosinusitis: a randomized clinical trial

Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK‐3β/β‐Catenin Pathway

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