New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors

Mohammadi, Saeed; ArefNezhad, Reza; Danaii, Shahla; Yousefi, Mehdi

doi:10.1002/biof.1634

Cited by 9 publications

(5 citation statements)

References 134 publications

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“…Deregulation of the Hippo signaling pathway is related to various solid tumors, including lung, breast, liver, and ovary [ 80 ]. Signaling pathways alteration can cause Leukemia, and among them, the Hippo pathway possesses significant effects on leukemia tumorigenesis [ 81 ].…”

Section: Hippo Signaling Pathway and Interaction With Other Signaling Pathwaysmentioning

confidence: 99%

The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis

Noorbakhsh¹,

Hayatmoghadam

Jamali

et al. 2021

Cancer Cell Int

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Cancer can be considered as a communication disease between and within cells; nevertheless, there is no effective therapy for the condition, and this disease is typically identified at its late stage. Chemotherapy, radiation, and molecular-targeted treatment are typically ineffective against cancer cells. A better grasp of the processes of carcinogenesis, aggressiveness, metastasis, treatment resistance, detection of the illness at an earlier stage, and obtaining a better therapeutic response will be made possible. Researchers have discovered that cancerous mutations mainly affect signaling pathways. The Hippo pathway, as one of the main signaling pathways of a cell, has a unique ability to cause cancer. In order to treat cancer, a complete understanding of the Hippo signaling system will be required. On the other hand, interaction with other pathways like Wnt, TGF-β, AMPK, Notch, JNK, mTOR, and Ras/MAP kinase pathways can contribute to carcinogenesis. Phosphorylation of oncogene YAP and TAZ could lead to leukemogenesis, which this process could be regulated via other signaling pathways. This review article aimed to shed light on how the Hippo pathway interacts with other cellular signaling networks and its functions in leukemia.

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Section: Hippo Signaling Pathway and Interaction With Other Signaling Pathwaysmentioning

confidence: 99%

The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis

Noorbakhsh¹,

Hayatmoghadam

Jamali

et al. 2021

Cancer Cell Int

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“…Hepatocarcinogenesis and metastasis are complex multistep processes in which many signaling cascades are altered, leading to a heterogeneous molecular profile, which can have implications for the clinical management and prognosis of HCC patients 26,27 . The Hippo‐YAP signaling pathway has been the subject of many recent studies due to it being a critical cancer‐related pathway 28 . There has been increasing evidence demonstrating that lncRNAs interact with the Hippo cascade, thereby contributing to the attainment of multiple malignant hallmarks 23 .…”

Section: Discussionmentioning

confidence: 99%

“…26,27 The YAP signaling been the subject of many recent studies due to it being a critical cancer-related pathway. 28 There has been increasing evidence demonstrating that lncRNAs interact with the Hippo cascade, thereby contributing to the attainment of multiple malignant hallmarks. 23 Thus, Hippo signaling-related lncRNAs have become significant putative biomarkers and targets for therapy in human cancers.…”

Section: Discussionmentioning

confidence: 99%

LncRNA‐EWSAT1promotes hepatocellular carcinoma metastasis via activation of theSrc‐YAPsignaling axis

et al. 2022

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Regardless of the improvements in diagnostic and therapeutic methods, the clinical outcomes of hepatocellular carcinoma (HCC) patients remain poor. Although accumulating evidence indicates that lncRNAs (long noncoding RNAs) are essential within the control of tumorigenesis and the metastasis of cancer, the underlying mechanisms remain largely unknown. This work explored the pattern of expression and functional significance of a newly found lncRNA, Ewing sarcoma-associated transcript 1 (EWSAT1), in HCC metastasis. The results indicated that EWSAT1 was upregulated significantly in HCC relative to that in normal tissues and was correlated with an aggressive phenotype and low patient survival. Functional experiments demonstrated that EWSAT1 could promote proliferation and HCC cell metastasis both in vitro and in vivo. Mechanistically, EWSAT1 binds directly to Yes-associated protein (YAP), promotes Sarcoma gene (Src)-induced phosphorylation of YAP, facilitates nuclear translocation of YAP, and consequently, activates the transcription of Hippo-YAP signaling target genes involved in cancer evolution. This study found that EWSAT1 plays a crucial role in HCC metastasis and that it has the potential to be a prognosis biomarker and a target for therapeutics.

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“…Biological pathways are complex, interconnected series of molecular actions, genetically encoded within the genome, that regulate various cellular physiological and biochemical processes. Genetic variants associated with complex diseases, such as cancer, metabolic, neurological, and immune-related diseases, tend to be enriched in biological pathways (5,6). Genetic analyses of biological pathways play a central role in understanding the etiology of complex diseases and hold great potential to identify novel drug targets through elucidating unknown disease mechanisms (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bayesian Linear Regression Models for Gene Set Prioritization in Complex Diseases

Gholipourshahraki,

Bai,

Shrestha

et al. 2024

Preprint

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Genome-wide association studies (GWAS) provide valuable insights into the genetic architecture of complex traits, yet interpreting their results remains challenging due to the polygenic nature of most traits. Gene set analysis offers a solution by aggregating genetic variants into biologically relevant pathways, enhancing the detection of coordinated effects across multiple genes. In this study, we present and evaluate a gene set prioritization approach utilizing Bayesian Linear Regression (BLR) models to uncover shared genetic components among different phenotypes and facilitate biological interpretation. Through extensive simulations and analyses of real traits, we demonstrate the efficacy of the BLR model in prioritizing pathways for complex traits. Simulation studies reveal insights into the model’s performance under various scenarios, highlighting the impact of factors such as the number of causal genes, proportions of causal variants, heritability, and disease prevalence. Application of both single-trait and multi-trait BLR models to real data, specifically GWAS summary data for type 2 diabetes (T2D) and related phenotypes, identifies significant associations with T2D-related pathways. Furthermore, comparison between single- and multi-trait BLR analyses highlights the superior performance of the multi-trait approach in identifying associated pathways, showcasing increased statistical power when analyzing multiple traits jointly. Additionally, enrichment analysis with integrated data from various public resources supports our results, confirming significant enrichment of diabetes-related genes within the top T2D pathways resulting from the multi-trait analysis. The BLR model’s ability to handle diverse genomic features, perform regularization, conduct variable selection, and integrate information from multiple traits, genders, and ancestries demonstrates its utility in understanding the genetic architecture of complex traits. Our study provides insights into the potential of the BLR model to prioritize gene sets, offering a flexible framework applicable to various datasets. This model presents opportunities for advancing personalized medicine by exploring the genetic underpinnings of multifactorial traits, potentially leading to tailored therapeutic interventions.

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New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors

Cited by 9 publications

References 134 publications

The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis

The Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis

LncRNA‐EWSAT1promotes hepatocellular carcinoma metastasis via activation of theSrc‐YAPsignaling axis

Evaluation of Bayesian Linear Regression Models for Gene Set Prioritization in Complex Diseases

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