New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia

González-­Peña, Diana; Checa, Antonio; Ancos, Begoña de; Wheelock, Craig E.; Sánchez‐Moreno, Concepción

doi:10.1016/j.redox.2016.12.002

Cited by 22 publications

(14 citation statements)

References 55 publications

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“…The current results showed, however, that R+ treatment significantly reduced (p<0.05) TG levels when combined to the HC diet (C+/R+ rats) but failed to reduce TC levels. Contradicting findings with regard to TC responses have also been reported by others [14,15]. These discrepancies may have been a result of time length for resveratrol administration, likely being capable of TC reduction only when applied for longer periods (surely >5 days) [16].…”

Section: Discussionmentioning

confidence: 70%

“…Consistent with other studies [14] done on rats fed comparable HC provoking diet for a period of 4 weeks, the HC-inducing diet used in our present trial also triggered remarkable (p<0.01) HC. The chronic combination of dietary cholate (cholic acid) with high cholesterol has been directly linked to HC, chiefly through the activation of adhesive and pro-inflammatory molecules and enzymes (namely, thromboxane A 2 and cyclooxygenases 1 and 2 [15]).…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol mitigates hypercholesterolemia exacerbated hyperthermia in chronically heat-stressed rats

et al. 2019

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Background and Aim: Hypercholesterolemia (HC) is the major leading cause of cardiovascular disease worldwide. Such atherogenic aberration deeply impacts blood circulation. Resveratrol (R) is a polyphenol that has received attention as a hypolipidemic, antioxidant, and vascular agility advocate. Efficient blood redistribution is a key element in mammalian thermoregulation. We hypothesized that R treatment may aid in mitigating hyperthermic responses under both acute and chronic heat stress (HS) conditions in HC male rats. Materials and Methods: All rats were initially fitted with miniaturized thermologgers to measure core body temperature (Tcore). With a 2 × 2 factorial arrangement, four groups were randomly allotted, in which half of the animals ingested an HC diet (C+), while the other half ingested a control (C-) diet, throughout the whole study duration of 35 days. Seven rats from each dietary treatment, however, received R (R+; 13 mg/kg BW/day), while the rest received normal saline (R-) for 5 continuous days. All animals were maintained at thermoneutrality (TN; ambient temperature; Ta=23.15±0.04°C) for a period of 30 continuous days (days 0-29). On day 29, an acute HS (HS; Ta=35.86±0.37°C; for 9 nocturnal h) was imposed. Then, from day 29, a chronic HS protocol (Ta=32.28±1.00°C) was maintained until the past day of the trial (day 34), after which blood samples were drawn for analyses of platelet (PL) count, total antioxidant activity (TAO), total cholesterol (TC), triglycerides (TGs), and lipid peroxidation (LP). Results: Switching animals from TN to HS resulted in abrupt rises in Tcore. The HC diet induced a significant (p<0.01) hyperlipidemia over the control of diet-consuming rats. Interestingly, the hyperthermic response to acute HS was highly pronounced in the rats consuming the C- diet, while the C+ diet exacerbated the chronic HS-induced hyperthermia. Despite failure to improve TAO in the C+ diet, R+ treatment caused a marked (p<0.05) decline in nighttime - hyperthermia in C+ rats, likely by enhancing blood flow to extremities (for heat dissipation) as delineated by drastic downregulations of C+ related rises in PL, TC, TG, and LP (HC diet by R+ interaction; p<0.03). Conclusion: The hyperthermic response in C- groups was attributed to higher amount of feed intake than those consuming the C+ diet. Yet, the R+ improvement of thermoregulation in the C+ group was likely related to enhancement of vascular hemodynamics. Resveratrol intake mitigated chronic HS-evoked hyperthermia in rats. Such an approach is worthy to follow-up in other mammals and humans.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Resveratrol mitigates hypercholesterolemia exacerbated hyperthermia in chronically heat-stressed rats

et al. 2019

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“…This metabolic screening indicated specific metabolites and related metabolic pathways, which have encouraged the development of multiplatform metabolic fingerprinting of liver tissues. In addition, the present study has been motivated by a recent work that showed that onion supplementation ameliorated certain HC diet-related changes in liver oxylipins, which might be linked with a positive impact on the hepatic inflammatory process [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this sense, it is known that the expression of hepatic fatty acid elongase and desaturase is regulated by nutrients, hormones and nuclear receptor agonists [ 25 ]. Additionally, onion and quercetin and quercetin derivatives, which are the main flavonols in onion, are able to affect the fatty acid metabolism by modifying the activity of numerous enzymes such as lipoxygenase (LOX), cyclooxygenase (COX) and cytochrome P450 (CYP) [ 19 , 26 , 27 , 28 ]. They are also able to alter the expression profiles of several lipid metabolism-related genes [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

González-Peña

Dudzik

Garcı́a

et al. 2017

IJMS

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The consumption of functional ingredients has been suggested to be a complementary tool for the prevention and management of liver disease. In this light, processed onion can be considered as a source of multiple bioactive compounds with hepatoprotective properties. The liver fingerprint of male Wistar rats (n = 24) fed with three experimental diets (control (C), high-cholesterol (HC), and high-cholesterol enriched with onion (HCO) diets) was obtained through a non-targeted, multiplatform metabolomics approach to produce broad metabolite coverage. LC-MS, CE-MS and GC-MS results were subjected to univariate and multivariate analyses, providing a list of significant metabolites. All data were merged in order to figure out the most relevant metabolites that were modified by the onion ingredient. Several relevant metabolic changes and related metabolic pathways were found to be impacted by both HC and HCO diet. The model highlighted several metabolites (such as hydroxybutyryl carnitine and palmitoyl carnitine) modified by the HCO diet. These findings could suggest potential impairments in the energy−lipid metabolism, perturbations in the tricarboxylic acid cycle (TCA) cycle and β-oxidation modulated by the onion supplementation in the core of hepatic dysfunction. Metabolomics shows to be a valuable tool to evaluate the effects of complementary dietetic approaches directed to hepatic damage amelioration or non-alcoholic fatty liver disease (NAFLD) prevention.

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“…Other cellular proteins, like nuclear factor erythroid 2-related factor 2 (Nrf-2) [12,13,14], p53 [15,16], AMP-activated protein kinase [17,18], proliferator-activated receptor γ [19], and NAD-dependent deacetylase sirtuin-1 (SIRT1) [20] are also targets of allium-derived sulfur species. Consequently, many sulfur molecules have been reported to have anticancer properties [21,22,23,24], are anti-inflammatory [7,25,26,27], act as cytoprotective agents [28,29], function as inhibitors of metastasis [30,31], and alter lipid metabolism [32,33]. Additionally, molecules like diallyl trisulfide (DATS) release hydrogen sulfide gas (H 2 S) in the presence of glutathione and cysteine [34].…”

Section: Introductionmentioning

confidence: 99%

An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic

Rose

Moore

Whiteman³

et al. 2019

Molecules

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Alliums and allied plant species are rich sources of sulfur compounds that have effects on vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in mammals. In view of the multiple biological effects ascribed to these sulfur molecules, researchers are now using these compounds as inspiration for the synthesis and development of novel sulfur-based therapeutics. This research has led to the chemical synthesis and biological assessment of a diverse array of sulfur compounds representative of derivatives of S-alkenyl-l-cysteine sulfoxides, thiosulfinates, ajoene molecules, sulfides, and S-allylcysteine. Many of these synthetic derivatives have potent antimicrobial and anticancer properties when tested in preclinical models of disease. Therefore, the current review provides an overview of advances in the development and biological assessment of synthetic analogs of allium-derived sulfur compounds.

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New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia

Cited by 22 publications

References 55 publications

Resveratrol mitigates hypercholesterolemia exacerbated hyperthermia in chronically heat-stressed rats

Resveratrol mitigates hypercholesterolemia exacerbated hyperthermia in chronically heat-stressed rats

Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats

An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic

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