New Insights into the Evolution of Metazoan Cadherins and Catenins

Hulpiau, Paco; Gul, Ismail Sahin; Roy, Frans van

doi:10.1016/b978-0-12-394311-8.00004-2

Cited by 46 publications

(56 citation statements)

References 74 publications

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“…␣E-and ␣N-catenins are 82% identical in sequence, whereas ␣T-catenin is more distantly related (59% identity to ␣E-catenin). ␣E-Catenin is the most widely expressed family member, whereas ␣N-catenin expression is limited to neurons, and ␣T-catenin is restricted to cardiomyocytes and testicular peritubular myoid cells (7). Mammalian ␣E-catenin is the best characterized member of the family.…”

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confidence: 99%

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Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

Pokutta

Choi

Ahlsén

et al. 2014

Journal of Biological Chemistry

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Background: Cadherin cell adhesion molecules are linked to the actin cytoskeleton by the proteins ␤-and ␣-catenin. Results: The interactions of ␣-catenins in the cadherin⅐␤-catenin⅐␣-catenin complex have been thermodynamically and structurally defined. Conclusion:The architecture of ␣-catenin enables regulation of its interactions in the adhesive complex. Significance: The data provide molecular insights into the regulation of the cadherin⅐catenin complex.

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confidence: 99%

“…The ␣-catenin gene family in amniotes consists of three members, ␣E (epithelial)-, ␣N (neuronal)-, and ␣T (testis and heart)-catenins (7). ␣E-and ␣N-catenins are 82% identical in sequence, whereas ␣T-catenin is more distantly related (59% identity to ␣E-catenin).…”

mentioning

confidence: 99%

Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

Pokutta

Choi

Ahlsén

et al. 2014

Journal of Biological Chemistry

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“…Ft and Ds orthologs are highly conserved among metazoans, with a remarkable consistency in the exact number of extracellular cadherin repeats across hundreds of millions of years of evolution (Hulpiau et al, 2013). Ft and Ds might have established planar cell polarity in a simple ancestral epithelium.…”

Section: Functional Domains Of Fat and Dachsousmentioning

confidence: 99%

Regulation of long-range planar cell polarity by Fat-Dachsous signaling

Sharma

McNeill

2013

Development

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“…About 114 cadherins and cadherin-related molecules have been identified in humans (Hulpiau et al 2013). During development and at mature stages, epithelial and neuronal cells express a "cadherin code" involved in cell fate specification, morphogenetic and cellular rearrangements, the maintenance of tissue integrity, and intracellular signal transduction (Nelson 2008;Harris and Tepass 2010;Takeichi 2011;Hirano and Takeichi 2012;El-Amraoui and Petit 2013).…”

Section: Introductionmentioning

confidence: 99%

Cadherins in the Auditory Sensory Organ

El-Amraoui

Petit

2016

The Cadherin Superfamily

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The exquisite sensitivity and frequency tuning of hearing depend on the correct structure and functioning of the auditory sensory hair cells, the neighbouring supporting cells, and the homeostasis of their ionic environment. The increasing number of adhesion proteins identified as causing hearing impairment in humans and mice when defective is consistent with a critical role for cellcell junctions between neighbouring epithelial cells of the cochlea, and of fibrous links within the hair bundle, the sensory hair cell structure responsible for sound reception. Classical cadherins and/or associated adherens-junction proteins, such as p120-catenin or nectin 3, have been shown to be essential for establishment of the regular mosaic cellular pattern of the auditory sensory epithelium. Two cadherinrelated proteins, protocadherin-15 and cadherin-23, are key components of both lateral links and tip-links in hair bundles; they are essential components of the mechanoelectrical transduction machinery. Studies of the role of these adhesion proteins and of the pathogenesis of the forms of deafness caused by defects of these proteins have provided considerable insight into the development and functioning of the auditory sensory epithelium, and of the hair cells in particular.

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New Insights into the Evolution of Metazoan Cadherins and Catenins

Cited by 46 publications

References 74 publications

Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

Structural and Thermodynamic Characterization of Cadherin·β-Catenin·α-Catenin Complex Formation

Regulation of long-range planar cell polarity by Fat-Dachsous signaling

Cadherins in the Auditory Sensory Organ

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