New insights into the influence of myo-inositol on carbohydrate metabolism during osmoregulation in Nile tilapia (Oreochromis niloticus)

Zhu, Jiahua; Chen, Liqiao; Huang, Yuxing; Zhang, Fan; Pan, Jingyu; Li, Erchao; Qin, Jianguang; Qin, Chuanjie; Wang, Xiaodan

doi:10.1016/j.aninu.2022.04.006

Cited by 19 publications

(6 citation statements)

References 77 publications

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“…Similar to our findings, studies in Cyprinus carpio Songpu have shown that a decrease in dietary protein levels could reduce free radical production and oxidative stress caused by alkalinity stress [8]. In addition, the antioxidant defense system seems to be closely related to energy metabolism [32,50]. In this study, the low-protein diet group had more carbohydrates, and carbohydrate catabolism can provide much energy for the body's response to oxidative stress.…”

Section: Discussionsupporting

confidence: 89%

“…This may be because tilapia fed with high-carbohydrate diet could better cope with osmotic regulation caused by alkalinity stress. Carbohydrates are the direct energy supply to aquatic animals under salinity stress [14,31,32]. The correlation analysis of this study also showed that WG and SGR were significantly negatively correlated with ion transport, while FCR was significantly positively correlated with ion transport.…”

Section: Discussionsupporting

confidence: 62%

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Reducing Dietary Protein Content by Increasing Carbohydrates Is More Beneficial to the Growth, Antioxidative Capacity, Ion Transport, and Ammonia Excretion of Nile Tilapia (Oreochromis niloticus) under Long-Term Alkalinity Stress

Liu,

Xu,

et al. 2023

Aquaculture Nutrition

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Alkalinity stress is the main stress experienced by aquatic animals in saline–alkali water, which hinders the aquaculture development and the utilization of water resources. The two-factor (2 × 3) test was adopted to study the influence of dietary protein to carbohydrate ratios on the energy metabolism of Nile tilapia (Oreochromis niloticus) under different alkalinity stress levels. Three diets with different protein-carbohydrate ratios (P27/C35, P35/C25, and P42/C15) were fed to fish cultured in freshwater (FW, 1.3 mmol/L carbonate alkalinity) or alkaline water (AW, 35.7 mmol/L carbonate alkalinity) for 50 days. Ambient alkalinity decreased tilapia growth performance. Although ambient alkalinity caused oxidative stress and enhanced ion transport and ammonia metabolism in tilapia, tilapia fed the P27/C35 diet showed better adaptability than fish fed the other two diets in alkaline water. Further metabolomic analysis showed that tilapia upregulated all the pathways enriched in this study to cope with alkalinity stress. Under alkalinity stress, tilapia fed the P27/C35 diet exhibited enhanced pyruvate metabolism and purine metabolism compared with tilapia fed the P42/C15 diet. This study indicated that ambient alkalinity could significantly decrease growth performance and cause oxidative stress and osmotic regulation. However, reducing dietary protein content by increasing carbohydrates could weaken stress and improve growth performance, ion transport, and ammonia metabolism in tilapia under long-term hyperalkaline exposure.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 62%

Reducing Dietary Protein Content by Increasing Carbohydrates Is More Beneficial to the Growth, Antioxidative Capacity, Ion Transport, and Ammonia Excretion of Nile Tilapia (Oreochromis niloticus) under Long-Term Alkalinity Stress

Liu,

Xu,

et al. 2023

Aquaculture Nutrition

Self Cite

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“…In fish, glutathione peroxidase (GSH-PX) is a common antioxidant enzyme that can remove excess damaging reactive oxygen species (ROS) and protect cells from damage caused by ROS through lipid peroxidation [ [36] , [37] , [38] ]. Malondialdehyde (MDA) is used as a biomarker of lipid peroxidation in tissues, which can reflect the degree of oxidative damage in vivo, and high levels of MDA lead to high cytotoxicity [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Bacillus halophilus on growth, intestinal flora and metabolism of Larimichthys crocea

Huang,

Shui,

Wang

et al. 2023

Biochemistry and Biophysics Reports

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“…The feed additive groups were fed with feeds containing 0.01% resveratrol, 0.05% bile acid, 0.01% allicin, 0.1% betaine, and 0.01% inositol, respectively. The dosage of the additive was chosen according to the previous cyprinid fish studies [24][25][26][27]. The descriptions of the feed are shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…0.001% DMSO (v/v) was added into the Con group, and 15 μ g/L BPA (0.001% DMSO (v/v) as solvent) was added to BPA group and the 5 feed additive groups. The concentration of BPA was selected with reference to our previous studies, which was the environment-related concentration [ 11 , 24 ]. Half of the water in each tank was replaced daily with fresh dechlorinated tap water dosed with the appropriate amount of BPA.…”

Section: Methodsmentioning

confidence: 99%

Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A

Zhang

Jiang

Wang

et al. 2022

Aquaculture Nutrition

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The fatty liver is one of the main problems in aquaculture. In addition to the nutritional factors, endocrine disrupter chemicals (EDCs) are one of the causes of fatty liver in fish. Bisphenol A (BPA) is a plasticizer widely used in the production of various plastic products and exhibits certain endocrine estrogen effects. Our previous study found that BPA could increase the accumulation of triglyceride (TG) in fish liver by disturbing the expression of lipid metabolism-related genes. How to recover the lipid metabolism disorder caused by BPA and other environmental estrogens remains to be explored. In the present study, Gobiocypris rarus was used as a research model, and 0.01% resveratrol, 0.05% bile acid, 0.01% allicin, 0.1% betaine, and 0.01% inositol were added to the feed of the G. rarus that exposed to 15 μg/L BPA. At the same time, a BPA exposure group without feed additives (BPA group) and a blank group with neither BPA exposure nor feed additives (Con group) were setted. The liver morphology, hepatosomatic index (HSI), hepatic lipid deposition, TG level, and expression of lipid metabolism-related genes were analyzed after 5 weeks of feeding. The HSI in bile acid and allicin groups was significantly lower than that in Con group. The TG in resveratrol, bile acid, allicin, and inositol groups returned to Con level. Principal component analysis of TG synthesis, decomposition, and transport related genes showed that dietary bile acid and inositol supplementation had the best effect on the recovery of BPA-induced lipid metabolism disorder, followed by allicin and resveratrol. In terms of lipid metabolism-related enzyme activity, bile acid and inositol were the most effective in recovering BPA-induced lipid metabolism disorders. The addition of these additives had a restorative effect on the antioxidant capacity of G. rarus livers, but bile acids and inositol were relatively the most effective. The results of the present study demonstrated that under the present dosage, bile acids and inositol had the best improvement effect on the fatty liver of G. rarus caused by BPA. The present study will provide important reference for solving the problem of fatty liver caused by environmental estrogen in aquaculture.

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New insights into the influence of myo-inositol on carbohydrate metabolism during osmoregulation in Nile tilapia (Oreochromis niloticus)

Cited by 19 publications

References 77 publications

Reducing Dietary Protein Content by Increasing Carbohydrates Is More Beneficial to the Growth, Antioxidative Capacity, Ion Transport, and Ammonia Excretion of Nile Tilapia (Oreochromis niloticus) under Long-Term Alkalinity Stress

Reducing Dietary Protein Content by Increasing Carbohydrates Is More Beneficial to the Growth, Antioxidative Capacity, Ion Transport, and Ammonia Excretion of Nile Tilapia (Oreochromis niloticus) under Long-Term Alkalinity Stress

Effects of Bacillus halophilus on growth, intestinal flora and metabolism of Larimichthys crocea

Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A

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