New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

Wang, Hao; Peng, Daoquan

doi:10.1186/1476-511x-10-176

Cited by 117 publications

(87 citation statements)

References 90 publications

(98 reference statements)

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“…This was expected, as obese subjects who are otherwise healthy generally exhibit this clinical phenotype. 31,32 However, at study conclusion, both cholesterol and triglyceride levels were significantly improved toward the normal range in the supplement cohort but not in placebo. Similarly, fasting glucose levels were reduced to 95 mg/dL in the treated group, whereas placebo glucose levels remained above 100 mg/dL.…”

Section: Discussionmentioning

confidence: 86%

Efficacy and Tolerability of an Herbal Formulation for Weight Management

Stern

Peerson

Mishra³

et al. 2013

Journal of Medicinal Food

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The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled, clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40 kg/m 2 . Participants were randomized into two groups receiving either 400 mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000 kcal/day) throughout the study and walked 5 days a week for 30 min. The primary outcome was reduction in body weight. Secondary outcomes were reduction in BMI and in waist and hip circumference. Serum glycemic, lipid, and adiponectin levels were also measured. Ninety-five subjects completed the trials, and data from these two studies were pooled and analyzed. At study conclusion (8 weeks), statistically significant reductions in body weight (5.2 kg; P < .0001), BMI (2.2 kg/m 2 ; P < .0001), as well as waist (11.9 cm; P < .0001) and hip circumferences (6.3 cm; P = .0001) were observed in the herbal group compared with placebo. An increase in serum adiponectin concentration was also found in the herbal group versus placebo (P = .0008) at study conclusion along with reductions in fasting blood glucose (12.2%, P = .01), cholesterol (13.8%, P = .002), and triglyceride (41.6%, P < .0001) concentrations. No changes were seen across organ function panels, multiple vital signs, and no major adverse events were reported. The minor adverse events were equally distributed between the two groups. Our findings suggest that the herbal blend appears to be a well-tolerated and effective ingredient for weight management.

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Section: Discussionmentioning

confidence: 86%

Efficacy and Tolerability of an Herbal Formulation for Weight Management

Stern

Peerson

Mishra³

et al. 2013

Journal of Medicinal Food

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“…In obese adults, adipose tissues contain over 50 % of the total cholesterol (TC) in the body. Several previous in vivo and in vitro studies provided evidence that the adipocyte cholesterol efflux to HDL was under the control of ABCA1 [2]. ABCA1 polypeptide (ENSP00000363868, O95477) has two homologous halves, and contains 2261 amino acids (254.3 kDa) [11].…”

Section: Introductionmentioning

confidence: 99%

“…Increasing evidence has demonstrated that childhood obesity has profound effects on morbidity and mortality in adult life [1]. Obesity is associated with several co-morbid conditions, such as dyslipidemia, atherosclerosis, chronic heart disease, hypertension, stroke, diabetes mellitus, osteoarthritis, and some types of cancer [2,3]. The primary dyslipidemia related to obesity is characterized by increased circulating triglycerides (TGs), decreased highdensity lipoprotein (HDL) levels, and abnormal low-density lipoprotein (LDL) composition [4].…”

Section: Introductionmentioning

confidence: 99%

Functional and Structural Impact of ATP-Binding Cassette Transporter A1 R219K and I883M Gene Polymorphisms in Obese Children and Adolescents

et al. 2015

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“…LCAT esterifies the absorbed cholesterol and produces cholesterol ester (CE), contributing to the formation of mature HDL, thus preventing its early renal catabolism [32] . CVID and XLA patients have a pro-inflammatory status even in the absence of acute infectious processes, which may result in reduced synthesis of apo A-I, LCAT, and ABCA1, thus leading to lower HDL-c levels [33] .…”

Section: Discussionmentioning

confidence: 99%

Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

Vieira

Costa‐Carvalho

Hix³

et al. 2015

Ann Nutr Metab

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Introduction: Common variable immunodeficiency and X-linked agammaglobulinaemia are primary immunodeficiencies classified as antibody deficiencies, and they both result in hypogammaglobulinaemia. Objective: Evaluate the lipid profile and other cardiovascular risk biomarkers in CVID and XLA patients. Methods: In total, 24 patients and 12 healthy controls matched by age and gender were included in the study. We evaluated anthropometric measurements, and seric total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), apo A-I, small dense LDL (sdLDL), C-reactive protein (CRP), and tumour necrosis factor alpha (TNF-alpha), myeloperoxidase (MPO), cholesteryl ester transfer protein (CETP), and lecithin cholesterol acyltransferase (LCAT) were assessed. Results: CRP (p = 0.008) and TNF-alpha (p < 0.001) concentrations were significantly higher, whereas HDL-c (p = 0.025) and apo A-I (p = 0.013) levels were significantly lower in patients than in the controls. In the patient group, a negative and significant correlation was observed between HDL-c and TNF-alpha (r = -0.406; p = 0.049) and between HDL-c and TG (r = -0.641; p = 0.001). Conclusion: Common variable immunodeficiency and X-linked agammaglobulinaemia patients presented themselves with increased inflammatory markers associated with a decreased HDL-c and apo A-I levels, which can predispose to a high cardiovascular risk.

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New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

Cited by 117 publications

References 90 publications

Efficacy and Tolerability of an Herbal Formulation for Weight Management

Efficacy and Tolerability of an Herbal Formulation for Weight Management

Functional and Structural Impact of ATP-Binding Cassette Transporter A1 R219K and I883M Gene Polymorphisms in Obese Children and Adolescents

Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients

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