New insights into the mechanisms of French lavender essential oil on non-small-cell lung cancer cell growth

Justus, Barbara; Kanunfre, Carla Cristine; Budel, Jane Manfron; Faria, Mariane Ferreira de; Raman, Vijayasankar; Paula, Josiane Padilha de; Farago, Paulo Vítor

doi:10.1016/j.indcrop.2019.04.051

Cited by 21 publications

(20 citation statements)

References 28 publications

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“…A less common EO of lavender ( L. dentata ) was assayed on lung cancer cells Calu‐3 in an in‐vitro model which include both liquid and vapor phases. The oil showed cytotoxic activity in the vapor phase acting by necrotic and apoptotic processes not involving inhibition of P‐glycoprotein …”

Section: Essential Oils: Very Old ‘Guys’ With Great Prospectsmentioning

confidence: 99%

“…The oil showed cytotoxic activity in the vapor phase acting by necrotic and apoptotic processes not involving inhibition of P-glycoprotein. [353] Looking at published data several EOs show antiviral activity against many enveloped RNA and DNA viruses. Among our five EOs, thyme and oregano seems to have more consideration in this field.…”

Section: Eos and Human Healthmentioning

confidence: 99%

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New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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Section: Essential Oils: Very Old ‘Guys’ With Great Prospectsmentioning

confidence: 99%

Section: Eos and Human Healthmentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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“…The linear equation achieved was y=8065.1 x-6096, where y is the peak area and x is the standard solution concentration in µg/ml. A correlation coefficient of r=0.9998 was recorded, which suggested that the method was linear since an r value close to 1.0 could indicate the calibration curve suitability [32].…”

Section: Validation Methodsmentioning

confidence: 88%

Development and Validation of a Fast and Sensitive Uhplc-Pda Method for the Quantification of Ursolic Acid in Poly(l-Lactic Acid) Nanocapsules

Lyra

Koga

Novatski

et al. 2020

Asian J Pharm Clin Res

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Objective: The aim of the present study is to develop and validation of a ultra-high performance liquid chromatography (UHPLC) method to determine the ursolic acid content and its encapsulation efficiency (EE) in lipid-core nanocapsules prepared from poly (L-lactic acid). Methods: A simple UHPLC-PDA method was developed and validated for the quantitative determination of ursolic acid in poly(L-lactic acid) nanocapsules. The chromatographic conditions used were: RP-C18 column, isocratic mobile phase containing acetonitrile:water (92:8, v/v), flow rate of 0.8 ml/min, column temperature of 50°C, and detection at 203 nm. The following parameters were evaluated: Specificity, linearity, limits of detection and quantification, precision, accuracy, and robustness. Results: The method was specific to the ursolic acid and linear (r=0.9998) in the range of 10–100 μg/ml. The limits of detection and quantification were 1.35 and 4.10 μg/ml, respectively. The precision was demonstrated by a relative standard deviation less than 2%. Adequate accuracy (98.35%±0.82) was obtained. Changes in flow rate, mobile phase, and column temperature did not significantly alter the peak area and the retention time of the ursolic acid. The mean EE was 99.89%. Conclusion: The method proved to be fast, sensitive, and simple for quantifying ursolic acid in nanocapsules and was successfully used for determining the EE.

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“…Glandular trichomes represent one of the types of secretory structures of aromatic plants and produce and accumulate secondary metabolites with biological activities as seen in several families such as Asteraceae (Budel et al, a, b; Pereira et al, ), Lamiaceae (Conti et al, ; Justus et al, ), and Verbenaceae (Passos et al, ). The micromorphology, number, and distribution of glandular trichomes can be useful as distinguishing features at the subfamily level of Lamiaceae (Ascensão, Marques, & Pais, ).…”

Section: Resultsmentioning

confidence: 99%

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Almeida

Raman

Raeski

et al. 2020

Microscopy Res & Technique

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This article enumerates the detailed anatomy of Cantinoa althaeifolia (Lamiaceae) illustrated with light and scanning electron microscopy images. The anatomical markers include the presence of branched nonglandular trichomes and capitate, peltate, and clavate types of glandular trichomes; prismatic crystals on the leaf and stem surfaces; and oil droplets in the leaf mesophyll. Histochemical tests and EDS analyses were performed in order to detect the composition of certain cells and their contents. The key findings of the present study can contribute to the taxonomy, species identification, and quality control of Cantinoa althaeifolia. K E Y W O R D S crystals, leaf anatomy, micromorphology, stem anatomy, trichomes

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New insights into the mechanisms of French lavender essential oil on non-small-cell lung cancer cell growth

Cited by 21 publications

References 28 publications

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Development and Validation of a Fast and Sensitive Uhplc-Pda Method for the Quantification of Ursolic Acid in Poly(l-Lactic Acid) Nanocapsules

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

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