New Insights Into the Mechanisms of Green Tea Catechins in the Chemoprevention of Prostate Cancer

Connors, Shahnjayla K.; Chornokur, Ganna; Kumar, Nagi B.

doi:10.1080/01635581.2012.630158

Cited by 73 publications

(55 citation statements)

References 173 publications

(406 reference statements)

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“…Similar effects have been described for two synthetic enantiomeric analogs of natural GTCs in PCa cells [133]. The observed accumulation of short-lived proteins, normally addressed to proteosomal degradation such as p21, p27, Bax and ikΒα, in PCa cells after EGCG or GTCs treatment indirectly confirms, that GTCs exert inhibitory effect on the proteasome activity [98,134].…”

Section: Proteasome Inhibitionsupporting

confidence: 62%

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Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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Green Tea Catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human Prostate Cancer (PCa) chemoprevention.In the last decades many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets including, cell surface receptors, lipid rafts and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentration that cannot be achieved in vivo.Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs bioavailability through still poor understood mechanisms. Recent efforts to develop delivery systems that increase GTCs overall bioavailability, by mean of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.

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Section: Proteasome Inhibitionsupporting

confidence: 62%

“…Effects of GTCs on GSTP1reexpression are discussed in the next paragraph. NF-kB is constitutively activated in PCa cells, prostate premalignant lesions (intraepithelial tumors, PIN) and PCa tissues [98]. EGCG has been demonstrated to inhibit NF-kB [99,102] and in TRAMP mice [16].…”

Section: Effects Of Gtcs On Regulation Of Gene Expressionmentioning

confidence: 99%

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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show abstract

“…Most dealt with cancer in general or mechanistic aspects of carcinogenesis, only a few reviews focused on the prevention of specific cancer types like lung cancer [39][40][41], breast cancer [42,43], colon cancer [44], prostate cancer [14,[45][46][47] and gastric cancer [48]. Epidemiological evidence for the protective effects of GTE for cancer of all types has been reviewed in 2009 by Boehm et al [37], using the Cochrane collaboration criteria for randomized prospective studies.…”

Section: Green Tea and Cancermentioning

confidence: 99%

Green Tea and Its Extracts in Cancer Prevention and Treatment

et al. 2017

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Green tea (GT) and green tea extracts (GTE) have been postulated to decrease cancer incidence. In vitro results indicate a possible effect; however, epidemiological data do not support cancer chemoprevention. We have performed a PubMED literature search for green tea consumption and the correlation to the common tumor types lung, colorectal, breast, prostate, esophageal and gastric cancer, with cohorts from both Western and Asian countries. We additionally included selected mechanistical studies for a possible mode of action. The comparability between studies was limited due to major differences in study outlines; a meta analysis was thus not possible and studies were evaluated individually. Only for breast cancer could a possible small protective effect be seen in Asian and Western cohorts, whereas for esophagus and stomach cancer, green tea increased the cancer incidence, possibly due to heat stress. No effect was found for colonic/colorectal and prostatic cancer in any country, for lung cancer Chinese studies found a protective effect, but not studies from outside China. Epidemiological studies thus do not support a cancer protective effect. GT as an indicator of as yet undefined parameters in lifestyle, environment and/or ethnicity may explain some of the observed differences between China and other countries.

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“…Epigallocatechin-3-gallate, a major ingredient of Green tea catechins , has been reported to exert a variety of biological effects, including antioxidant, antibacterial, anti-inflammatory and anticarcinogenic activities. Additionally, it has been reported that this ingredient inhibits lipopolysaccharide (LPS)-induced inflammatory cytokine production [81][82][83].…”

Section: Maintenance Of Oral Hygienementioning

confidence: 99%

Healthy Lifestyle For Healthy Gums

N¹

2014

Dentistry

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When we think about dental health, focus is likely to be on preventing cavities, caries and decayed teeth but it's important to pay attention to gums too. Gums play a major role not only in dental health, but in overall well-being of a person. Gingival disease begins with bacterial growth in the mouth and may end-if not properly treated-with tooth loss due to destruction of the surrounding tissue.

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New Insights Into the Mechanisms of Green Tea Catechins in the Chemoprevention of Prostate Cancer

Cited by 73 publications

References 173 publications

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Green Tea and Its Extracts in Cancer Prevention and Treatment

Healthy Lifestyle For Healthy Gums

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