New insights into the mechanisms of diastolic dysfunction in patients with type 2 diabetes

Bayraktar, Al; Canpolat, Uğur; Demiri, Edis; Kunak, Ayşegül Ülgen; Özer, Necla; Aksöyek, Serdar; Övünç, Kenan; Özkan, Adem; Yildiz, Bülent O.; Atalar, Enver

doi:10.3109/14017431.2015.1039571

Cited by 3 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, recent clinical studies noted the importance of left ventricular diastolic dysfunction in the pathogenesis of HF. Furthermore, some researchers have indicated that AGEs or RAGE affected left ventricular diastolic function [ 26 , 27 ]. Wang et al reported the significant relationship of E/e′ as a marker of left ventricular diastolic function and skin AF in subjects at risk for cardiovascular diseases [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Skin Autofluorescence in Patients With Type 2 Diabetes Mellitus With Chronic Heart Failure

Hatori¹

2018

Cardiol Res

View full text Add to dashboard Cite

BackgroundRecent clinical studies have shown that skin autofluorescence (AF) levels are significantly associated with diabetic complications. In contrast, data regarding the relationships between skin AF and chronic heart failure (CHF) are limited. The aim of this study was to clarify the clinical significance of skin AF in patients with type 2 diabetes mellitus (DM) with CHF.MethodsThis cross-sectional study enrolled 257 outpatients with type 2 DM with CHF who were treated medically (96 men and 161 women; mean age, 79 ± 7 years). Associations between skin AF and various clinical parameters were examined.ResultsIncidence of skin AF in patients with a history of hospitalization due to HF was significantly higher than in those without a history of hospitalization due to HF (3.0 ± 0.5 AU vs. 2.7 ± 0.5 AU, respectively, P < 0.001). Significant positive correlations were found between skin AF and various clinical parameters, such as E/e′ as a maker of left ventricular diastolic function (r = 0.30, P < 0.001), high-sensitivity cardiac troponin T levels as a marker of myocardial injury (r = 0.45, P < 0.001), reactive oxygen metabolite levels as an oxidative stress marker (r = 0.31, P < 0.001), and cardio-ankle vascular index as a marker of arterial function (r = 0.38, P < 0.001). Furthermore, multiple regression analyses showed that these clinical parameters (E/e′ (β = 0.25, P < 0.001)), high-sensitivity cardiac troponin T levels (β = 0.30, P < 0.001), cardio-ankle vascular index (β = 0.21, P < 0.001), reactive oxygen metabolite levels (β = 0.15, P < 0.01), and a history of hospitalization due to HF (β = 0.23, P < 0.001) were independent variables when skin AF was used as a subordinate factor.ConclusionThe findings of this study showed that skin AF may be a determining factor for prognosis in patients with type 2 DM with CHF. Further investigations in a large prospective study, including intervention therapies, are required to validate the results of this study.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Skin Autofluorescence in Patients With Type 2 Diabetes Mellitus With Chronic Heart Failure

Hatori¹

2018

Cardiol Res

View full text Add to dashboard Cite

show abstract

“…The results of this study also revealed the E/e' ratio as a predictor of first HF hospitalization in patients with HFpEF. However, AGEs/AGE receptors (RAGEs) may affect left ventricular diastolic function through several pathways [25,26]. Moreover, several clinical reports exist demonstrating a significant relationship of left ventricular diastolic function and skin AF [27,28].…”

Section: Discussionmentioning

confidence: 99%

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Hatori¹

2020

Cardiol Res

View full text Add to dashboard Cite

Background: An autofluorescence (AF) reader can be used to diagnose skin AF non-invasively by measuring local accumulation of advanced glycation end-products. A number of studies have investigated the relationships between skin AF and cardiovascular disease. However, data regarding the usefulness of skin AF as a predictor of chronic heart failure remain limited. This prospective study aimed to elucidate the usefulness of skin AF as a predictor of first heart failure (HF) hospitalization in patients with HF with preserved ejection fraction (HFpEF).Methods: A total of 412 outpatients with HFpEF with no history of HF hospitalization were enrolled. Patients were assigned to either the low (group L; skin AF ≤ 2.9 arbitrary units (AU); n = 303) or the high (group H; skin AF ≥ 3.0 AU; n = 109) group according to optimal skin AF cut-off levels determined using receiver operating characteristic curves. Clinical parameters and the usefulness of skin AF as a predictor of first HF hospitalization were evaluated. Results:The E/e' ratio as a marker of left ventricular diastolic function was significantly higher in group H patients than in group L patients at baseline (group H, 11.8 ± 3.8; group L, 10.6 ± 3.3; P = 0.002). During the 72.7-month follow-up period, 43 HF cases were hospitalized (group L, 15 cases; group H, 28 cases; P < 0.001, log-rank test). Multivariate Cox regression analyses revealed that group H exhibited a significantly higher risk of first HF hospitalization than did group L (hazard ratio, 2.26; 95% confidence interval, 1.21 -3.52; P = 0.014). Conclusions:The present study demonstrated that skin AF can predict the risk of first HF hospitalization in patients with HFpEF. Prospective studies, including intervention therapies, are required to validate our observations.

show abstract

Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Verboven

Deluyker

Ferferieva

et al. 2018

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

New insights into the mechanisms of diastolic dysfunction in patients with type 2 diabetes

Abstract: Our study showed that serum sRAGE level was significantly lower in type 2 diabetic patients aged < 50 years old. Also, sRAGE has negative correlation with the duration of diabetes and it was significantly associated with the presence of diastolic dysfunction in type 2 diabetes.

Cited by 3 publications

References 28 publications

Clinical Significance of Skin Autofluorescence in Patients With Type 2 Diabetes Mellitus With Chronic Heart Failure

Clinical Significance of Skin Autofluorescence in Patients With Type 2 Diabetes Mellitus With Chronic Heart Failure

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Western diet given to healthy rats mimics the human phenotype of diabetic cardiomyopathy

Contact Info

Product

Resources

About