New insights into the molecular basis of how physical activity contributes to human health

Westphal, Anika

doi:10.1111/apha.14047

Acta Physiologica

2023

DOI: 10.1111/apha.14047

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New insights into the molecular basis of how physical activity contributes to human health

Anika Westphal

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2024

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Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Mitchell,

Bliss,

Church

2024

Biomolecules

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Parkinson’s disease (PD) is a prevalent neurodegenerative disease in which treatment often includes an exercise regimen. Exercise is neuroprotective in animal models of PD, and, more recently, human clinical studies have verified exercise’s disease-modifying effect. Aerobic exercise and resistance training improve many of PD’s motor and non-motor symptoms, while neuromotor therapy and stretching/flexibility exercises positively contribute to the quality of life in people with PD. Therefore, understanding the role of exercise in managing this complex disorder is crucial. Exerkines are bioactive substances that are synthesized and released during exercise and have been implicated in several positive health outcomes, including neuroprotection. Exerkines protect neuronal cells in vitro and rodent PD models in vivo. Aerobic exercise and resistance training both increase exerkine levels in the blood, suggesting a role for exerkines in the neuroprotective theory. Many exerkines demonstrate the potential for protecting the brain against pathological missteps caused by PD. Every person (people) with Parkinson’s (PwP) needs a comprehensive exercise plan tailored to their unique needs and abilities. Here, we provide an exercise template to help PwP understand the importance of exercise for treating PD, describe barriers confronting many PwP in their attempt to exercise, provide suggestions for overcoming these barriers, and explore the role of exerkines in managing PD. In conclusion, exercise and exerkines together create a powerful neuroprotective system that should contribute to slowing the chronic progression of PD.

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Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Mitchell,

Bliss,

Church

2024

Biomolecules

View full text Add to dashboard Cite

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New insights into the molecular basis of how physical activity contributes to human health

Cited by 1 publication

References 19 publications

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

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