New insights into the protection of dietary components on anxiety, depression, and other mental disorders caused by contaminants and food additives

Xiong, Ruo-Gu; Li, Jiahui; Cheng, Jin; Wu, Si-Xia; Huang, Siyu; Zhou, Dan-Dan; Saimaiti, Adila; Shang, Ao; Tang, Guo‐Yi; Li, Hua Bin; Gan, Ren‐You; Feng, Yibin

doi:10.1016/j.tifs.2023.06.004

Cited by 13 publications

(3 citation statements)

References 110 publications

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“…Cortes et al summarized that the acquisition and retrieval of spatial information were disrupted in adult mice exposed to MSG in the neonatal stage ( Olvera-Cortés et al, 2005 ; López-Vázquez et al, 2019 ; Christian et al, 2020 ). The nesting behavior was studied by Hassan et al using MSG-treated C57BL/6 mice and 70% of the MSG-treated animals showed poor cognitive abilities in terms of the short-term working memory and exploratory behavior as observed in a recent study ( Xiong et al, 2023 ).…”

Section: Discussionmentioning

confidence: 96%

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

Ankul,

Chandran,

Anuragh

et al. 2023

Front. Pharmacol.

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This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer’s disease-like condition to enhance translational research. Our review seeks to understand how MSG affects the brain and causes degenerative disorders. Due to significant preclinical data linking glutamate toxicity to Alzheimer’s disease and the lack of a comprehensive review or meta-analysis, we initiated a study on MSG’s potential link. We searched PubMed, ScienceDirect, ProQuest, DOAJ, and Scopus for animal research and English language papers without time constraints. This study used the PRISMA-P framework and PICO technique to collect population, intervention or exposure, comparison, and result data. It was registered in PROSPERO as CRD42022371502. MSG affected mice’s exploratory behaviors and short-term working memory. The brain, hippocampus, and cerebellar tissue demonstrated neuronal injury-related histological and histomorphometric changes. A total of 70% of MSG-treated mice had poor nesting behavior. The treated mice also had more hyperphosphorylated tau protein in their cortical and hippocampus neurons. Glutamate and glutamine levels in the brain increased with MSG, and dose-dependent mixed horizontal locomotor, grooming, and anxiety responses reduced. MSG treatment significantly decreased phospho-CREB protein levels, supporting the idea that neurons were harmed, despite the increased CREB mRNA expression. High MSG doses drastically lower brain tissue and serum serotonin levels. In conclusion, MSG showed AD-like pathology, neuronal atrophy, and short-term memory impairment. Further research with a longer time span and deeper behavioral characterization is needed.Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier [CRD42022371502].

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Section: Discussionmentioning

confidence: 96%

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

Ankul,

Chandran,

Anuragh

et al. 2023

Front. Pharmacol.

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“…Contamination of food with these compounds can occur at different stages of production, such as during cultivation, processing, packaging, transportation, and storage. These molecules also have various ways of contaminating non-target organisms, such as through contact via water, food, or air (Xiong et al 2023), which makes humans an easy target for contamination, as we are exposed throughout these processes. Contamination becomes more pronounced when considering the occupational exposure of rural workers who are directly and daily exposed to these chemicals (Ong-Artborirak et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio)

Oliveira,

Gallas-Lopes,

Chitolina

et al. 2024

Preprint

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Carbofuran (CF) is a carbamate class pesticide, widely used in agriculture for pest control in crops. On the other hand, CF is also detected as a contaminant in food and water sources. This pesticide has high toxicity in non-target organisms, and its presence in the environment poses a threat to the ecosystem. Research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (AChE), inducing an accumulation of acetylcholine in the brain. Consequently, this leads to the emergence of a cholinergic syndrome and various detrimental effects on human health. Nonetheless, our understanding of CF impact on the central nervous system remains elusive. Therefore, this study aimed to investigate the effects of CF on behavioral and neurochemical parameters in adult zebrafish. The animals were exposed for 96 hours to different concentrations of CF (5, 50, and 500 μg/L) and subjected to behavioral assessments in the novel tank test (NTT) and social preference test (SPT). Subsequently, they were euthanized, and their brains were used to evaluate neurochemical markers associated with oxidative stress and AChE levels. In the NTT and SPT, CF did not alter the evaluated behavioral parameters. Furthermore, CF did not affect the levels of AChE, non-protein sulfhydryl groups, and thiobarbituric acid reactive species in the zebrafish brain. However, further research is needed regarding the environmental exposure of this compound to non-target organisms.

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“…On the other hand, the gut microbiota and its metabolites have a significant influence on preserving the overall health of the host; gut microbiota dysbiosis has been reported to be associated with the occurrence and development of several chronic metabolic diseases, such as obesity, diabetes mellitus, and cancers [ 5 , 6 , 7 , 8 , 9 ]. Moreover, gut microbiota can also be correlated with mental health, which has received increasing attention in recent years [ 10 , 11 , 12 , 13 , 14 ]. It was reported that the gut microbiota could influence the brain and mental health in several ways, such as the vagus nerve, microbial regulation of neuro-immune signaling, microbiota-mediated tryptophan metabolism, microbial control of neuroendocrine function, and microbial production of neuroactive compounds [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Xiong

Cheng

et al. 2023

Nutrients

Self Cite

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The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention and treatment strategies for mental disorders. Several gut microbiota, especially Firmicutes and Bacteroidetes, are demonstrated to affect mental health through microbiota–gut–brain axis, and the gut microbiota dysbiosis can be related to mental disorders, such as anxiety, depression, and other mental disorders. On the other hand, dietary components, including probiotics (e.g., Lactobacillus and Bifidobacterium), prebiotics (e.g., dietary fiber and alpha-lactalbumin), synbiotics, postbiotics (e.g., short-chain fatty acids), dairy products, spices (e.g., Zanthoxylum bungeanum, curcumin, and capsaicin), fruits, vegetables, medicinal herbs, and so on, could exert protective effects against mental disorders by enhancing beneficial gut microbiota while suppressing harmful ones. In this paper, the mental disorder-associated gut microbiota are summarized. In addition, the protective effects of dietary components on mental health through targeting the gut microbiota are discussed. This paper can be helpful to develop some dietary natural products into pharmaceuticals and functional foods to prevent and treat mental disorders.

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New insights into the protection of dietary components on anxiety, depression, and other mental disorders caused by contaminants and food additives

Cited by 13 publications

References 110 publications

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio)

The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

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