New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases

Li, Xiaojing; Liu, Qiaohong; Pan, Yuqing; Chen, Si; Zhao, Yu; Hu, Yiyang

doi:10.3389/fphar.2023.1097835

Cited by 23 publications

(17 citation statements)

References 190 publications

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“…ALDH2 also revealed a significant correlation with TG and LDL-C. TG is the primary dietary lipid, so the level of TG is almost only influenced by dietary habits ( 81 ). The higher TG level of GG populations demonstrated unhealthier dietary habits than GA/AA populations.…”

Section: Discussionmentioning

confidence: 99%

The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis

Liu,

Peng,

Zhang

et al. 2024

Front. Endocrinol.

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IntroductionAcetaldehyde dehydrogenase 2 (ALDH2) had reported as a prominent role in the development of cardiometabolic diseases among Asians. Our study aims to investigate the relationship between ALDH2 polymorphism and cardiometabolic risk factors in East Asian population.MethodWe searched databases of PubMed, Web of Science, and Embase updated to Oct 30th, 2023. We extracted data of BMI, Hypertension, SBP, DBP, T2DM, FBG, PPG, HbA1c, TG, TC, LDL-C and HDL-C.ResultIn total, 46 studies were finally included in our meta-analysis, containing, 54068 GG and, 36820 GA/AA participants. All outcomes related to blood pressure revealed significant results (hypertension OR=0.83 [0.80, 0.86]; SBP MD=-1.48 [-1.82, -1.14]; DBP MD=-1.09 [-1.58, -0.61]). FBG showed a significant difference (MD=-0.10 [-0.13, -0.07]), and the lipid resulted significantly in some outcomes (TG MD=-0.07 [-0.09, -0.04]; LDL-C MD=-0.04 [-0.05, -0.02]). As for subgroups analysis, we found that in populations without severe cardiac-cerebral vascular diseases (CCVDs), GG demonstrated a significantly higher incidence of T2DM (T2DM OR=0.88 [0.79, 0.97]), while the trend was totally opposite in population with severe CCVDs (T2DM OR=1.29 [1.00, 1.66]) with significant subgroup differences.ConclusionOur updated meta-analysis demonstrated that ALDH2 rs671 GG populations had significantly higher levels of BMI, blood pressure, FBG, TG, LDL-C and higher risk of hypertension than GA/AA populations. Besides, to the best of our knowledge, we first report GG had a higher risk of T2DM in population without severe CCVDs, and GA/AA had a higher risk of T2DM in population with severe CCVDs.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023389242.

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Section: Discussionmentioning

confidence: 99%

The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis

Liu,

Peng,

Zhang

et al. 2024

Front. Endocrinol.

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“…Therefore, the increased TG is likely not related to the coffee cherry pulp juice concentrate but rather to other causes. The most common contributor to the increase in triglyceride is the intake of high-calorie food [ 38 ]. Although we asked all participants to maintain their eating behavior and record their diet three days per week throughout the study, there could be some changes in diet intake on the days that were not on the records.…”

Section: Discussionmentioning

confidence: 99%

Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers

2023

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Coffee cherry pulp, a major waste product from coffee manufacturing, contains polyphenols with antioxidant activity. However, its clinical safety and health benefits are unclear. This randomized, double-blinded, placebo-controlled trial evaluated the safety and potential efficacy of coffee cherry pulp juice concentrate. A total of 61 participants were randomly divided into a study group (n = 30), receiving the juice, and a control group (n = 31), receiving a placebo drink of 14 g twice daily for 12 weeks. Adverse symptoms, changes in body weight, hematological and biochemical parameters, vital signs, and heart function were evaluated using subject diaries, interviews, blood and urine tests, and electrocardiograms. The results showed no intervention-related adverse events. Body weight, liver, renal function, complete blood counts, blood glucose, urinalysis, and electrocardiograms were not significantly altered throughout the study. Consuming the juice for at least 8 weeks significantly decreased cholesterol and LDL levels. The glucose levels were maintained significantly better than those of the placebo group. The findings suggest that continuously consuming 28 g/day of coffee pulp juice concentrate for 12 weeks is safe in healthy volunteers. Future studies could employ a dose of ≤28 g/day to investigate the efficacy of this novel food, especially for preventing dyslipidemia and diabetes.

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“…It can be assumed that all the mechanisms associated with dietary triglycerides hydrolysis, fatty acid uptake, triglycerides resynthesis in ER, chylomicron assembly, trafficking through the Golgi complex, and secretion processes, may be influenced by HFD. [ 36 ] Importantly, the dietary fatty acid profile remains an important determinant of obesity risk. [ 37 ] In particular, SFAs have been shown to contribute more to obesity than monounsaturated fatty acids (MUFAs) and PUFAs due to the greater propensity for SFAs to be stored in adipose tissue rather than being oxidized.…”

Section: A Crucial Role Of Fatty Acids In the Cellular Mechanisms Reg...mentioning

confidence: 99%

High Fat Diet–Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies

Haneishi,

Treppiccione,

Maurano

et al. 2024

Molecular Nutrition Food Res

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The intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In celiac disease (CD), the serum phospholipid profile in infants who developed CD is dramatically different when compared to that of infants at risk of CD not developing the disease. In a mouse model of gluten sensitivity, oral wheat gliadin challenge in connection with inhibition of the metabolism of arachidonic acid, an omega‐6 polyunsaturated fatty acid, specifically induces the enteropathy. Recent evidence suggests that gluten may play a role also for development of life‐style related diseases in populations on a high fat diet (HFD). However, the mechanisms behind these effects are not yet understood. Exploratory studies in mice feed HFD show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota, and the immune cell profile in liver.

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New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases

Cited by 23 publications

References 190 publications

The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis

The ALDH2 gene rs671 polymorphism is associated with cardiometabolic risk factors in East Asian population: an updated meta-analysis

Twelve-Week Safety and Potential Lipid Control Efficacy of Coffee Cherry Pulp Juice Concentrate in Healthy Volunteers

High Fat Diet–Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies

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