2010
DOI: 10.1242/jcs.070490
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New insights into the role of mitochondria in aging: mitochondrial dynamics and more

Abstract: SummaryA decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. A deeper understanding of the intricate nature of mitochondrial dynamics, which is described as the balance between mitochondrial fusion and fission, has revealed that functional and structural alterations in mitochondrial morphology are important factors in several key pathologies associated with aging. Indeed, a recent wave of studies has demonstrated the pleiotropic role of … Show more

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Cited by 465 publications
(399 citation statements)
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References 152 publications
(170 reference statements)
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“…It may be possible that mitochondrial dysfunction in ageing cells contributes to oxidative stress. 35 LHstimulated StAR protein expression and testosterone production were reduced in primary rat Leydig cells when exposed to H 2 O 2 , which demonstrates the harmful effects of ROS on steroidogenesis. Taken together, our data demonstrate that aged Leydig cells have an autophagic deficiency, an increased number of dysfunctional mitochondria and an increased ROS level.…”
Section: Discussionmentioning
confidence: 90%
“…It may be possible that mitochondrial dysfunction in ageing cells contributes to oxidative stress. 35 LHstimulated StAR protein expression and testosterone production were reduced in primary rat Leydig cells when exposed to H 2 O 2 , which demonstrates the harmful effects of ROS on steroidogenesis. Taken together, our data demonstrate that aged Leydig cells have an autophagic deficiency, an increased number of dysfunctional mitochondria and an increased ROS level.…”
Section: Discussionmentioning
confidence: 90%
“…A decrease in mitochondrial activity is closely linked with cellular dysfunction and aging, highlighting the importance of functional mitochondria for cell survival (Lin and Beal 2006;Rodolfo et al 2010;Seo et al 2010). Neuronal cell populations rely heavily on correct mitochondrial function because of their increased requirement for Ca 2þ buffering and ATP at their synaptic termini.…”
Section: Mitochondrial Quality Controlmentioning
confidence: 99%
“…11,12 Mitochondrial quality is maintained via the optimal balance between biogenesis and degradation for renewal, and mitochondria are also highly dynamic organelles undergoing continuous fusion and fission cycles. 13,14 Fusion has been shown to rescue damaged mitochondria by redistributing proteins and by maintaining mitochondrial DNA integrity. 15 In case of more extensive damage, segregation of irreversibly damaged mitochondria through fission is a prerequisite for appropriate engulfment and degradation via mitochondria selective autophagy known as mitophagy.…”
Section: Introductionmentioning
confidence: 99%