New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

Zieger, Elisabeth; Schubert, Michael

doi:10.1016/bs.ircmb.2016.09.001

Cited by 26 publications

(20 citation statements)

References 483 publications

(727 reference statements)

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“…Vertebrate RARs are ligand-activated transcription factors that act as constitutive repressors in the absence of a ligand [ 98 ]. RARs bind different isomers of the small, lipophilic molecule retinoic acid (RA), such as all- trans -RA, 9- cis -RA or 13- cis -RA, with all- trans -RA being the main biologically active RA isomer [ 99 ]. RA acts as a morphogen, whose functions are mediated by RARs.…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

“…RA acts as a morphogen, whose functions are mediated by RARs. During vertebrate development, RA signaling is, for example, required for axial patterning, nervous system development and organogenesis, with HOX genes being amongst the major targets of this signaling pathway [ 99 , 100 ]. Most bilaterian genomes contain a single RAR gene [ 17 , 27 , 36 , 49 , 50 , 101 , 102 , 103 ].…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

“…Many elements of a vertebrate-like RA signaling system are present in invertebrate deuterostomes, including the genes encoding the receptors and the enzymes required for the synthesis and degradation of endogenous RA [ 99 ]. In tunicates that have not secondarily lost the RAR gene, RAR-dependent RA signaling is implicated in neurogenesis as well as in tissue regeneration and bud development of budding tunicates [ 104 , 105 ].…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

“…In tunicates that have not secondarily lost the RAR gene, RAR-dependent RA signaling is implicated in neurogenesis as well as in tissue regeneration and bud development of budding tunicates [ 104 , 105 ]. The cephalochordate amphioxus is characterized by the most vertebrate-like RA signaling system of all invertebrates [ 99 , 106 ]. It has been demonstrated that the amphioxus RAR/RXR heterodimer can be activated by all- trans -RA, that HOX genes are directly regulated by RAR/RXR and that HOX-mediated RA signaling is essential for neurogenesis and axial patterning [ 107 ].…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

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Nuclear Receptors and Development of Marine Invertebrates

Miglioli

Canesi

Gomes

et al. 2021

Genes

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Nuclear Receptors (NRs) are a superfamily of transcription factors specific to metazoans that have the unique ability to directly translate the message of a signaling molecule into a transcriptional response. In vertebrates, NRs are pivotal players in countless processes of both embryonic and adult physiology, with embryonic development being one of the most dynamic periods of NR activity. Accumulating evidence suggests that NR signaling is also a major regulator of development in marine invertebrates, although ligands and transactivation dynamics are not necessarily conserved with respect to vertebrates. The explosion of genome sequencing projects and the interpretation of the resulting data in a phylogenetic context allowed significant progress toward an understanding of NR superfamily evolution, both in terms of molecular activities and developmental functions. In this context, marine invertebrates have been crucial for characterizing the ancestral states of NR-ligand interactions, further strengthening the importance of these organisms in the field of evolutionary developmental biology.

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Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

See 2 more Smart Citations

Nuclear Receptors and Development of Marine Invertebrates

Miglioli

Canesi

Gomes

et al. 2021

Genes

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“…A range of co-activators and co-repressors have been reported in modulating RA signaling activity [129]. In the developing CNS, RA is required for neural patterning, differentiation, proliferation, and the establishment of neurotransmitter systems [130]. RA from the meninges regulates cortical neuron generation [131].…”

Section: Altered Retinoic Acid Signaling In Asdmentioning

confidence: 99%

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk

Kumar

Reynolds

et al. 2019

J Neurodevelop Disord

107

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Background The development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental disorder, autistic patients display a few key characteristics, such as the impaired social interactions and elevated repetitive behaviors, suggesting the perturbation of specific neuronal circuits resulted from abnormal signaling pathways during brain development in ASD. A comprehensive review for autistic signaling mechanisms and interactions may provide a better understanding of ASD etiology and treatment. Main body Recent studies on genetic models and ASD patients with several different mutated genes revealed the dysregulation of several key signaling pathways, such as WNT, BMP, SHH, and retinoic acid (RA) signaling. Although no direct evidence of dysfunctional FGF or TGF-β signaling in ASD has been reported so far, a few examples of indirect evidence can be found. This review article summarizes how various genetic and non-genetic factors which have been reported contributing to ASD interact with WNT, BMP/TGF-β, SHH, FGF, and RA signaling pathways. The autism-associated gene ubiquitin-protein ligase E3A ( UBE3A ) has been reported to influence WNT, BMP, and RA signaling pathways, suggesting crosstalk between various signaling pathways during autistic brain development. Finally, the article comments on what further studies could be performed to gain deeper insights into the understanding of perturbed signaling pathways in the etiology of ASD. Conclusion The understanding of mechanisms behind various signaling pathways in the etiology of ASD may help to facilitate the identification of potential therapeutic targets and design of new treatment methods.

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Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube

2020

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The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field.

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New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

Cited by 26 publications

References 483 publications

Nuclear Receptors and Development of Marine Invertebrates

Nuclear Receptors and Development of Marine Invertebrates

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk

Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube

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