New insights into the t-complex and control of sperm function

Fraser, Lynn R.; Dudley, Keith

doi:10.1002/(sici)1521-1878(199904)21:4<304::aid-bies6>3.0.co;2-h

Cited by 38 publications

(15 citation statements)

References 51 publications

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“…The best-known example of meiotic drive in mammals is the t-complex in mice (Silver 1985;Ardlie 1998;Fraser & Dudley 1999). Since most of the t-haplotypes found in mice, including those found in natural populations, are homozygous lethals (Silver 1985), and driver males are disadvantaged in sperm competition, females that are carriers of t-haplotypes can reduce the risk of immediate reproductive failure by mating multiply.…”

Section: Discussionmentioning

confidence: 99%

Female multiple mating behaviour, early reproductive failure and litter size variation in mammals

Stockley

2003

Proc. R. Soc. Lond. B

105

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Female promiscuity is widespread among mammals, although its function is poorly understood. Recently, much interest has been generated by the hypothesis that female promiscuity, combined with postcopulatory paternity-biasing mechanisms, may function to reduce the costs of reproductive failure resulting from genetic incompatibility. Here, a comparative approach is used to determine if average rates of reproductive failure differ for polytocous mammal species with contrasting levels of female multiple-mating behaviour. After control for phylogeny, promiscuous species were found to have significantly lower rates of early reproductive failure than monogamous and polygynous species, in which females are relatively monandrous. Monandrous females appear to compensate for higher early reproductive failure with increased ova production, and thus produce comparable average litter sizes to those of more promiscuous females. However, there is significantly more variation around the average litter sizes produced by relatively monandrous females. These findings are broadly consistent with predictions of the genetic incompatibility avoidance hypothesis, although it is emphasized that alternative explanations cannot be ruled out on the basis of the comparative evidence presented. Further studies are needed to explore ecological correlates of multiple-mating behaviour, to investigate potential post-copulatory paternity-biasing mechanisms, and to identify the causes of reproductive failure in natural mammal populations.

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Section: Discussionmentioning

confidence: 99%

Female multiple mating behaviour, early reproductive failure and litter size variation in mammals

Stockley

2003

Proc. R. Soc. Lond. B

105

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“…Despite strong selection against them, t-alleles persist because they are associated with segregation distortion in males (Bruck 1957;review in Lyttle 1991), with heterozygous males passing t-alleles to more than 90% of their offspring. Although heterozygous males produce equal numbers of t and wild type sperm, the wild type sperm are damaged in some way, reducing their fertilization ability (Fraser & Dudley 1999).…”

Section: The T-complex In Micementioning

confidence: 99%

Genetic compatibility, mate choice and patterns of parentage: Invited Review

2000

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There is growing interest in the possibility that genetic compatibility may drive mate choice, including gamete choice, particularly from the perspective of understanding why females frequently mate with more than one male. Mate choice for compatibility differs from other forms of choice for genetic benefits (such as 'good genes') because individuals are expected to differ in their mate preferences, changing the evolutionary dynamics of sexual selection. Recent experiments designed to investigate genetic benefits of polyandry suggest that mate choice on the basis of genetic compatibility may be widespread. However, in most systems the mechanisms responsible for variation in compatibility are unknown. We review potential sources of variation in genetic compatibility and whether there is any evidence for mate choice driven by these factors. Selfish genetic elements appear to have the potential to drive mate compatibility mate choice, though as yet there is only one convincing example. There is abundant evidence for assortative mating between populations in hybrid zones, but very few examples where this is clearly a result of selection against mating with genetically less compatible individuals. There are also numerous cases of inbreeding avoidance, but little evidence that mate choice or differential fertilization success driven by genetic compatibility occurs between unrelated individuals. The exceptions to this are a handful of situations where both the alleles causing incompatibility and the alleles involved in mate choice are located in a chromosome region where recombination is suppressed. As yet there are only a few potential sources of genetic compatibility which have clearly been shown to drive mate choice. This may reflect limitations in the potential for the evolution of mate choice for genetic compatibility within populations, although the most promising sources of such incompatibilities have received relatively little research.

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“…The presence of tmACs in sperm has been investigated using different methodologies, including enzymatic assays (15), mass spectrometry (16), and mouse knock-out studies (17). Although many studies concluded that tmACs were present in mammalian sperm (17)(18)(19)(20)(21), an equally large number of studies could not find evidence of the presence of tmAC in these cells (22)(23)(24)(25)(26)(27)(28). In the one genetic study demonstrating a role for a tmAC in male fertility using Adcy3 null mice, it was unclear whether Adcy3 played a role in mature sperm or whether it contributed to fertility during spermatogenesis (17).…”

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confidence: 99%

Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm

Wertheimer

Krapf

Vega-Beltrán

et al. 2013

Journal of Biological Chemistry

101

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Background: cAMP is essential for the acquisition of sperm fertilizing capacity. The presence of transmembrane adenylyl cyclases (tmACs) in sperm remains controversial. Results: tmAC activity and its activator G s are detected in the sperm head. Conclusion: Two cAMP synthesis pathways coexist in sperm and lead to capacitation. Significance: Understanding capacitation is essential for improvement of assisted fertilization and for finding novel contraceptive targets.

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New insights into the t-complex and control of sperm function

Cited by 38 publications

References 51 publications

Female multiple mating behaviour, early reproductive failure and litter size variation in mammals

Female multiple mating behaviour, early reproductive failure and litter size variation in mammals

Genetic compatibility, mate choice and patterns of parentage: Invited Review

Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm

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