New insights into therapy by mathematical analysis: Recalcitrant granulated improved more than sclerotic venous leg ulcers with amelogenin treatment

Renner, Regina; Simon, Jan C.

doi:10.1016/j.jdermsci.2012.04.007

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…A new therapeutic option for this strategy is amelogenin, which aggregates under physiological condition to form larger hydrophobic structures like ECM [34]. The development of bioengineering has enabled us to use allograft-derived skin substitutes.…”

Section: Introduction Of Living Skin Equivalents Into Wound Tissuementioning

confidence: 99%

Attempts to accelerate wound healing

Kasuya

Tokura

2014

Journal of Dermatological Science

200

134

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Section: Introduction Of Living Skin Equivalents Into Wound Tissuementioning

confidence: 99%

Attempts to accelerate wound healing

Kasuya

Tokura

2014

Journal of Dermatological Science

200

134

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Vascular Leg Ulcers

Misciali¹,

Dika²,

Baraldi³

et al. 2014

The American Journal of Dermatopathology

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Vascular leg ulcers remain a challenge for the modern health care, and a systematic pathological study on this kind of lesions has not been reported so far. A total of 293 consecutive white patients with chronic leg ulcers (present for a minimum of 6 months and up to several years) referred to the Wound Care Unit (Dermatology, University of Bologna) between March 2008 and June 2011. Thirty-four patients affected by other than vascular ulcers, neoplastic or inflammatory conditions, were excluded. The remaining 259 patients affected by vascular leg ulcers were enrolled in this study. Assessment of the patients general health, skin biopsy, and vascular Doppler of the lower limbs were performed to determine the etiology and to formulate an appropriate management plan, whereas 2 punch biopsies of 3 mm were performed on the border and on the bed of each ulcer. Doppler evaluation showed the presence of vascular hemodynamic impairment in 259 patients. Of these, 181 (69.9%) patients were affected by venous insufficiency, 58 (22.4%) by venous and arterial insufficiency, and 20 (7.7%) by arterial insufficiency. Histopathologic features revealed significant differences, thus, reflecting the clinicopathologic correlation with the underlying hemodynamic impairments. In conclusion, histopathologic and hemodynamic data correlation could provide the basis for future analysis of leg ulcers pathogenesis and may improve treatment protocols. We should underline that this observational study represents a single-institute experience and that larger series are needed to confirm our observations.

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A European randomised controlled trial for venous leg ulcers: a mathematical model analysis

Renner

2020

J Wound Care

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Objective: Mathematical models have the potential to provide valuable insights into complex, biochemical and biomechanical processes. Previously, we developed a mathematical model with a non-linear growth function but could only confirm the feasibility of this model in clinical trials with a small number of patients. This limited the validity of our model. To increase validity, we applied the model to a larger number of patients. Method: The mathematical model was applied to patient data from a randomised controlled trial as part of the post-evaluation of the model. In this trial, patients with venous leg ulcers were randomised for treatment with either a two-layer bandage or a four-layer bandage. Results: Data for 186 patients were analysed (two-layer bandage group, n=93; four-layer bandage group, n=93). Using the non-linear growth function, it was confirmed that the two-layer bandage was not inferior to the four-layer bandage. In addition, the mathematical model calculated individual wound healing trajectories and mean wound healing trajectories for both bandage systems. By extrapolating to t→∞, the two-layer bandage had a marginal benefit and resulted in a persistent wound area that was 7% of the initial wound area compared with 17% for the four-layer bandage. Conclusion: This analysis supported the previously performed statistical analysis, and allowed us to obtain details of the treated study population that may help in non-inferiority trials via extrapolation. It also provided new insights into the wound healing process by generating wound healing trajectories.

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New insights into therapy by mathematical analysis: Recalcitrant granulated improved more than sclerotic venous leg ulcers with amelogenin treatment

Cited by 4 publications

References 16 publications

Attempts to accelerate wound healing

Attempts to accelerate wound healing

Vascular Leg Ulcers

A European randomised controlled trial for venous leg ulcers: a mathematical model analysis

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