New Insights into TRP Ion Channels in Stem Cells

Guo, Jing; Shan, Changliang; Xu, Jiao; Li, Mei; Zhao, Jiayu; Cheng, Wei

doi:10.3390/ijms23147766

Cited by 7 publications

(5 citation statements)

References 96 publications

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“…In order to provide significant and personalized therapeutic strategies for patients with high-grade gliomas, it is therefore necessary to accurately identify different GSC subtypes in high-grade gliomas. Increasing evidence has revealed that several ion channels belonging to the transient receptor potential (TRP) family are heterogeneously expressed in different types of cancer stem cells (CSCs); however, information on GSCs is limited [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

Morelli

Nabissi

Amantini

et al. 2022

IJMS

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The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide (TMZ) treatment. This last may be related to the heterogeneous expression of ion channels, among them TRPML2. Its mRNA expression was evaluated in two different neural stem cell (NS/PC) lines and sixteen GBM stem-like cells by qRT-PCR. The response to TMZ was evaluated in undifferentiated or differentiated GSCs, and in TRPML2-induced or silenced GSCs. The relationship between TRPML2 expression and responsiveness to TMZ treatment was evaluated by MTT assay showing that increased TRPML2 mRNA levels are associated with resistance to TMZ. This research was deepened by qRT-PCR and western blot analysis. PI3K/AKT and JAK/STAT pathways as well as ABC and SLC drug transporters were involved. Finally, the relationship between TRPML2 expression and overall survival (OS) and progression-free survival (PFS) in patient-derived GSCs was evaluated by Kaplan–Meier analysis. The expression of TRPML2 mRNA correlates with worse OS and PFS in GBM patients. Thus, the expression of TRPML2 in GSCs influences the responsiveness to TMZ in vitro and affects OS and PFS in GBM patients.

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Section: Introductionmentioning

confidence: 99%

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

Morelli

Nabissi

Amantini

et al. 2022

IJMS

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“… 150 Interestingly, studies have shown that miR-204 is substantially down-regulated due to hypermethylation of the TRPM3 promoter, which is related to enhanced cell stemness and migration. 137 In addition, in nude mouse brain transplant tumors, miR-204 restoration consistently inhibited tumor invasion and improved animal survival. 63 However, the role of TRPM3 and the regulatory function of miR-204 have been questioned.…”

Section: Signaling Pathways Of the Trpm Channels In Gliomamentioning

confidence: 98%

“… 63 Furthermore, DNA methylation of the TRPM3 promoter was positively correlated with glioma dryness and migration. 137 Moreover, TRPM3 has also been closely related to glioma growth and autophagy, 138 but its mechanism needs further research. In conclusion, methylation of the TRPM3 is involved in the malignant phenotype of glioma.…”

Section: Pathological Functions Of the Trpm Channels In Gliomamentioning

confidence: 99%

Roles of TRPM channels in glioma

Chen,

Xie,

Liu

et al. 2024

Cancer Biology & Therapy

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Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. More and more studies have shown that TRPM channels can be used as new therapeutic targets for glioma. In this review, we first introduce the structure, activation patterns, and physiological functions of TRPM channels. Additionally, the pathological mechanism of glioma mediated by TRPM2, 3, 7, and 8 and the related signaling pathways are described. Finally, we discuss the therapeutic potential of targeting TRPM for glioma.

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“…Some TRP affect skeletal calcium homeostasis interfering with intestinal calcium absorption (TRPV6), renal calcium reabsorption (TRPV5), OC differentiation (TRPV1,2,4,5) and chondrocytes (TRPV4) [ 29 ]. Furthermore, TRPV4, TRPA1 and TRPM7 are present in MSC together with the entire TRPC group and may regulate stem cells physiology and differentiation [ 129 ]. TRP are associated to bone resorption and osteoblast functions with a direct impact on osteoblastic and osteoclastic marker genes collagen 1 (COL1), ALP, osteocalcin (OCN), osteopontin (OPN), bone sialoprotein, Runx2, Cox2, c-Fos, tartrate-resistant acid phosphatase (TRAP), OPG/RANKL and NFATc1 [ 27 , 29 , 130 ].…”

Section: Ion Channels As Membrane Multi-sensors and Transducers In Bo...mentioning

confidence: 99%

The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis

et al. 2023

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The extracellular milieu is a rich source of different stimuli and stressors. Some of them depend on the chemical–physical features of the matrix, while others may come from the ‘outer’ environment, as in the case of mechanical loading applied on the bones. In addition to these forces, a plethora of chemical signals drives cell physiology and fate, possibly leading to dysfunctions when the homeostasis is disrupted. This variety of stimuli triggers different responses among the tissues: bones represent a particular milieu in which a fragile balance between mechanical and metabolic demands should be tuned and maintained by the concerted activity of cell biomolecules located at the interface between external and internal environments. Plasma membrane ion channels can be viewed as multifunctional protein machines that act as rapid and selective dual-nature hubs, sensors, and transducers. Here we focus on some multisensory ion channels (belonging to Piezo, TRP, ASIC/EnaC, P2XR, Connexin, and Pannexin families) actually or potentially playing a significant role in bone adaptation to three main stressors, mechanical forces, oxidative stress, and acidosis, through their effects on bone cells including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. Ion channel-mediated bone remodeling occurs in physiological processes, aging, and human diseases such as osteoporosis, cancer, and traumatic events.

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New Insights into TRP Ion Channels in Stem Cells

Cited by 7 publications

References 96 publications

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

Roles of TRPM channels in glioma

The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis

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