New insights on cytotoxic activity of group 3 and lanthanide compounds: complexes with [N,N,N]-scorpionate ligands

Saturnino, Carmela; Bortoluzzi, Marco; Napoli, Marco; Popolo, Ada; Pinto, Aldo; Longo, Pasquale; Paolucci, Gino

doi:10.1111/jphp.12112

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…The cytotoxicity of the compounds has been estimated on murine fibroscarcoma WHEI-164, rat glioma C6 and human embryonic kidney HEK-293 cells [89] . The cytotoxic activity of Sc(III), Y(III), and lanthanide(III) complexes of N,N'-dicyclohexyl-2,2-bis-(3,5-dimethyl-pyrazol-1-yl)-acetamidinate (Figure 11) has been assessed on human epithelial lung adenocarcinoma A549, human epithelial cervix adenocarcinoma HeLa, human melanoma A375, human embryonic kidney HEK-293 and murine macrophage J774.A1 cells [93] . [Sc(OiPr) 3 ] (iPr = isopropyl) have been isolated and structurally characterized.…”

Section: Table 3 the Biological Role And Toxic Effects Of D-elements ...mentioning

confidence: 99%

Survey of Recent Trends of IB-IVB Metals and Their Compounds in Cancer Treatment

Kostova

2024

Innov Discov

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Metals from IB to IVB groups of the periodic table, because of their flexible oxidation states, natures of coordinated bioligands, and geometries upon complexation, display various properties and efficiency of metal-based cytotoxic drugs. Recent decades have witnessed remarkable progress in the synthesis and therapeutic application of numerous inorganic compounds in cancer investigations. The main potential therapeutic agents, such as the complexes of platinum group metals possessing antineoplastic activity have been broadly described previously in the literature and are beyond the space of this analysis. The key objective of the present study is to analyze the possible activity of IB-IVB group metals their coordination compounds against the cancer cell types. The increasing number of anticancer drug candidates among these metals proves this field offers a remarkably variation of novel opportunities for the synthesis of advanced new pharmaceutics with diverse and specific modes of action. Furthermore, the review provides forthcoming insights into prospective clinical scenarios for approaching treatment applications. That is why this field of research deserves more attention. It is expected that this review can serve as a guiding framework for future investigations in cancer chemotherapy.

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Section: Table 3 the Biological Role And Toxic Effects Of D-elements ...mentioning

confidence: 99%

Survey of Recent Trends of IB-IVB Metals and Their Compounds in Cancer Treatment

Kostova

2024

Innov Discov

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“…Metallic nanoparticles are widely known to be cytotoxic , and heavy metals used for the process are not excreted by the body, leading to deposition and posing serious effects to the organ. These metals cannot be metabolized by the body, , and degradation is not possible . Therefore, tracing the excretion route is essential before use of the particles in in vivo imaging.…”

Section: Bioimaging With Emphasis On Mrimentioning

confidence: 99%

Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents

et al. 2017

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The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nanoparticles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation, and instability in some biological environments limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery, and in vivo imaging. Coating with amino acids, rather than peptides, offers further a highly cost-effective approach (due to their ease of purification and availability), but is currently an underutilized way to decrease toxicity and enhance stability. Amino acid molecules are small (<200 Da) and have both positive and negative charge groups (zwitterionic) facilitating charge-specific molecule binding. Additionally, amino acids exert by themselves some useful biological functions, with antibacterial and viability enhancing properties (for eukaryotic cells). Overall particle size, nanoparticle core, and the specific amino acid used to functionalize their surface influence their biodistribution, and their effects on host immunity. In this review, we provide for the first time an overview of this emerging field, and identify gaps in knowledge for future research.

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Complexes containing benzimidazolyl-phenol ligands and Ln(III) ions: Synthesis, spectroscopic studies and preliminary cytotoxicity evaluation

Hernández-Morales¹,

Rivera²,

López‐Monteon³

et al. 2019

Journal of Inorganic Biochemistry

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New insights on cytotoxic activity of group 3 and lanthanide compounds: complexes with [N,N,N]-scorpionate ligands

Cited by 7 publications

References 37 publications

Survey of Recent Trends of IB-IVB Metals and Their Compounds in Cancer Treatment

Survey of Recent Trends of IB-IVB Metals and Their Compounds in Cancer Treatment

Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents

Complexes containing benzimidazolyl-phenol ligands and Ln(III) ions: Synthesis, spectroscopic studies and preliminary cytotoxicity evaluation

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