New insights on the effects of ionic liquid structural changes at the gene expression level: Molecular mechanisms of toxicity in Daphnia magna

Jeremias, Guilherme; Jesus, Fátima; Ventura, Sónia P. M.; Gonçalves, Fernando; Asselman, Jana; Pereira, Joana Luísa

doi:10.1016/j.jhazmat.2020.124517

Cited by 25 publications

(4 citation statements)

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“…ILs also have good thermal stability and are tasteless, and can be easily recycled [ 14 ]. Furthermore, the physical and chemical properties of ILs vary widely depending on their chemical structure [ 15 ], and because of numerous possibilities of ILs structures by cation and anion selection, they are widely used in organic biocatalytic syntheses, clean fuel production, and in other applications [ 16 ]. However, several studies have shown that ILs can threaten human health and exert adverse environmental effects [ 17 ], and their toxicity varies with their structure and physical and chemical properties [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, several studies have shown that ILs can threaten human health and exert adverse environmental effects [ 17 ], and their toxicity varies with their structure and physical and chemical properties [ 18 ]. Therefore, ILs should be designed with caution considering their structure–ecotoxicity relationships [ 15 ]. In the present study, different ILs, and dispersants at varying solid: liquid ratios, concentration of the extraction solution, and extraction times were assessed for triterpenoid extraction from I. obliquus .…”

Section: Introductionmentioning

confidence: 99%

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Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography

et al. 2021

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Extracts of the fungus Inonotus obliquus exhibit cytotoxic properties against different cancers; hence, this fungal species has been extensively studied. This study aimed to extract total triterpenoids from Inonotus obliquus using ionic liquids (ILs) and separate potential lactate dehydrogenase (LDH) inhibitors via ultrafiltration (UF)-high-speed countercurrent chromatography (HSCCC). Total triterpenoids from Inonotus obliquus were extracted by performing a single-factor experiment and employing a central composite design via ultrasonic-assisted extraction (UAE) and heat-assisted extraction (HAE). The extract was composed of 1-butyl-3-methylimidazolium bromide as the IL and methanol as the dispersant. Ultrafiltration-liquid chromatography (UF-LC) was used to rapidly scan the LDH inhibitors and betulin and lanosterol were identified as potential inhibitors. To obtain these target compounds, betulin and lanosterol with the purities of 95.9% and 97.8% were isolated from HSCCC within 120 min. Their structures were identified using several techniques, among which IL-HAE was fast and effective. This study reports the extraction of triterpenoids from Inonotus obliquus by IL for the first time. Collectively, the findings demonstrate that UF-LC is an effective tool for screening potential LDH inhibitors from crude extracts of I. obliquus and may help to identify bioactive substances against myocardial infarction, whereas high-purity compounds can be separated via UF-HSCCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography

et al. 2021

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“…Due to the strong interaction among anions, cations, and other molecules, ILs have impacts on different degrees of life substances, from single proteins to intricate multicellular organisms. 7,[135][136][137][138][139] The interaction of ILs with biological systems has opened up a broad prospect for their application in biomedicine. In this section, we summarize the effects of ILs on cell membranes, organelles, nucleic acids and proteins.…”

Section: Therapeutic Mechanismsmentioning

confidence: 99%

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Hu,

Xing,

Yue

et al. 2023

Chem. Soc. Rev.

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“…Furthermore, due to the fact that ILs are purely ionic compounds, there is the possibility to design an enormous number of cation and anion combinations with different, specific properties. Although they have been hailed as "green solvents" not long ago, significant drawbacks, related mainly to their toxicity and persistence, have already been noticed (Samori et al 2007;Steudte et al 2014;Steudte et al 2012;Stolte et al 2008;Jeremias et al 2021;Yue et al 2021;Mena et al 2020;Khan et al 2021). However, data on their potential for accumulation in living organisms are still limited (Kowalska et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Interaction of ionic liquids with human serum albumin in the view of bioconcentration: a preliminary study

et al. 2022

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Bioaccumulation potential is critical in PBT and risk assessment of chemicals. However, for ionic liquids (ILs), this aspect remains neglected. It is especially important to fill this gap, because for this group of compounds, existing data confirm their risk of being environmentally persistent and toxicity. Moreover, considering preliminary reports on the interactions of ILs with lipids, it may be assumed that ILs have a higher potential for bioaccumulation than indicated by previous estimations built upon octanol–water partition coefficients. Moreover, the bioconcentration of ionizable chemical compounds may also be strongly related to plasma protein contents. Therefore, in this work, the affinity of a set of imidazolium cations and organic anions, and their combination to human serum albumin (HSA) was determined. The obtained results reveal that both cations and anions can be strongly bound to HSA, and blood proteins might play an important role in overall bioaccumulation. Furthermore, it was observed that HSA binding properties towards IL cations depend on the hydrophobicity of cations. The obtained data also provide indication that cation–anion interaction may affect ILs ions affinity to HSA.

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New insights on the effects of ionic liquid structural changes at the gene expression level: Molecular mechanisms of toxicity in Daphnia magna

Cited by 25 publications

References 100 publications

Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography

Total Triterpenoid Extraction from Inonotus Obliquus Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography

Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities

Interaction of ionic liquids with human serum albumin in the view of bioconcentration: a preliminary study

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