New Insights on the Fast Response of Poly(Ionic Liquid)s to Humidity: The Effect of Free-Ion Concentration

Nie, Jianxia; Xiao, Songhua; Tan, Rou; Wang, Taihong; Duan, Xiaochuan

doi:10.3390/nano9050749

Cited by 14 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymers 2020, 12, 2159 2 of 14 PILs consist of repeating groups containing ionic pairs in the polymer chain [26][27][28]. They have the unique properties of ionic liquids and exhibit increased mechanical strength and durability [27,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange

Niesyto

Neugebauer

2020

Polymers

View full text Add to dashboard Cite

Amphiphilic graft copolymers based on [2-(methacryloyloxy)ethyl]trimethyl- ammonium chloride (TMAMA) were obtained for the delivery of pharmaceutical ionic drugs, such as p-aminosalicylate (PAS) and clavunate (CLV) anions. The side chains were attached by grafting from a multifunctional macroinitiator via atom transfer radical polymerization (ATRP) to get polymers with different grafting degrees and ionic content. The self-assembling ability, confirmed by determining the critical micelle concentration (CMC) through interfacial tension (IFT) with the use of goniometry, was reduced after ion exchange (CMC twice higher than for chloride anions contained copolymers 0.005–0.026 mg/mL). Similarly, the hydrophilicity level (adjusted by the content of ionic fraction) evaluated by the water contact angle (WCA) of the polymer film surfaces was decreased with the increase of trimethylammonium units (68°–44°) and after introduction of pharmaceutical anions. The exchange of Cl− onto PAS− and CLV− in the polymer matrix was yielded at 31%–64% and 79%–100%, respectively. The exchange onto phosphate anions to release the drug was carried out (PAS: 20%–42%, 3.1–8.8 μg/mL; CLV: 25%–73%, 11–31 μg/mL from 1 mg of drug conjugates). Because of the bacteriostatic activity of PAS and the support of the action of the antibiotics by CLV, the designed water-soluble systems could be alternatives for the treatment of bacterial infections, including pneumonia and tuberculosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange

Niesyto

Neugebauer

2020

Polymers

View full text Add to dashboard Cite

show abstract

“…The introduction of ILs into hydrophobic polymeric matrices, e.g., PMMA, PUA, and PVDF, resulted in an easier and more efficient fabrication of firm moisture sensors. Nevertheless, few studies have described the fabrication of moisture-responsive materials based solely on ionic liquids immobilized on polymeric backbones (PILs). − …”

Section: Introductionmentioning

confidence: 99%

Humidity-Responsive Antimicrobial Membranes Based on Cross-Linked Copolymers Functionalized with Ionic Liquid Moieties

Druvari

Kyriakopoulou

Lainioti

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Humidity-responsive materials have attracted increasing attention for their potential use in various applications, e.g., sensors, soft robotics, and human–machine interfaces. Much effort has been focused on the use of ionic liquids for the construction of humidity-responsive sensors; yet, not enough attention has been paid on the susceptibility of the used poly(ionic liquid)s to microorganisms. This is especially relevant to the wide use of the polymers for biomedical applications, e.g., wearable body-condition sensors or healthcare control systems. We herein describe the development of dual functional, self-standing, monolayer antimicrobial membranes derived from cross-linked copolymers functionalized with ionic liquids. In a first step, random copolymers of poly(4-vinylbenzyl N-alkyl imidazolium chloride-co-acrylic acid), P(VBCImC n -co-AA20), were synthesized bearing aliphatic chains of different lengths (where n = 1, 4, 8, 12, 16 carbon atoms) to investigate the effect of hydrophobicity/hydrophilicity on the humidity-responsive properties of the copolymer and its antimicrobial activity. The aforementioned copolymers were later blended with the complementary reactive copolymers of poly(cetyl trimethylammonium 4-styrene sulfonate-co-glycidyl methacrylate), P(SSAmC16-co-GMA20), to provide highly stable films and coatings through thermal cross-linking. The membrane P(VBCImC12-co-AA20)/P(SSAmC16-co-GMA20) with a molar ratio of 3:1 (mol AA/mol GMA) exhibited immediate and high response to moisture through folding or flipping motions when placed on a wet filter paper or on the palm of a hand. The inhibition of growth for selected bacterial species (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) on the copolymer membranes was dependent on the length of the imidazolium alkyl chain and the species. Additionally, in the case of the cross-linked P(VBCImC n -co-AA20)/P(SSAmC16-co-GMA20) membranes, the overall efficacy was very high against all microorganisms tested, which, combined with their high humidity responsiveness, enables their potential application.

show abstract

“…3 Recently there has been rising interest in the formulation of poly-ionic liquid (PIL) based functional biomaterials across multiple research fields. 4,5 This is due to the combined properties of ionic liquids and their rich structures with desired functional groups. Poly-ionic liquids (PILs) are explored as a new class of functional polymers formed by fixing of charged moieties to the polymer backbone, which contains ionic liquid (IL) species in each monomeric unit.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically for biomedical applications, ILs are recognized for their biological activities and antimicrobial properties 3 . Recently there has been rising interest in the formulation of poly‐ionic liquid (PIL) based functional biomaterials across multiple research fields 4,5 . This is due to the combined properties of ionic liquids and their rich structures with desired functional groups.…”

Section: Introductionmentioning

confidence: 99%

A review on antibacterial potential of poly‐ionic liquid‐based biomaterials

Panda,

Samal,

Pradhan

2023

Journal of Polymer Science

View full text Add to dashboard Cite

In recent years, bacterial infection has become one of the significant clinical challenges. The overuse or misuse of antibiotics increases the number of antibiotic‐resistant bacterial pathogens and causes enormous medical burdens with high morbidity and mortality. Several strategies have been adopted to tackle this; poly‐ionic liquids (PILs), a class of ionic liquids (ILs) systems demonstrating a broad spectrum of antimicrobial activities, have been widely used in biomedical applications. During polymerization, the charge density of the cations, molecular weight, and hydrophobic behavior can be regulated to accomplish more potent antibacterial efficacy with low cytotoxicity. However, inadequate literature is available highlighting the application of PIL‐based materials in biomedical applications. Keeping this in mind, the recent advances in PIL‐based biomaterials formed by conjugating PIL with natural and synthetic polymers as effective antimicrobial agents have been the focus area of this review.

show abstract

New Insights on the Fast Response of Poly(Ionic Liquid)s to Humidity: The Effect of Free-Ion Concentration

Cited by 14 publications

References 39 publications

Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange

Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange

Humidity-Responsive Antimicrobial Membranes Based on Cross-Linked Copolymers Functionalized with Ionic Liquid Moieties

A review on antibacterial potential of poly‐ionic liquid‐based biomaterials

Contact Info

Product

Resources

About