New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury

Lemaitre, Dominique; Court, Felipe A.

doi:10.4103/1673-5374.306069

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…In their experimental work on CS of motor nerves, Lemaitre & Court state that the Wallerian degeneration environment activates a distinctive transcriptome profile (conducive to CS) in uninjured adjacent neurones. 8 Kuiken et al 9 demonstrated in their pioneering human work on targeted muscle reinnervation that motor nerves can take over and innervate new territories by implanting various upper limb motor nerves into denervated strips of pectoralis major muscle in a case of bilateral shoulder disarticulation amputee. This has been reproduced by others since then.…”

Section: Evaluation Of the Hypothesesmentioning

confidence: 99%

“…However, if no such barriers exist, as in the case of a single muscle supplied by two nerves, with one of those lesioned, CS-mediated motor territory expansion of the other nerve takes place, as shown by Lamaitre & Court in their animal experiments. 8 Targeted muscle reinnervation studies by Kuiken TA et al 9 showed that motor nerves can take over and innervate new muscles when surgically facilitated. There is evidence from other animal and human studies supporting the role of CS-led motor unit expansion and improved muscle power after PNI and other lower motor neurones (LMN) lesions with partial paralysis of muscles.…”

Section: Introductionmentioning

confidence: 99%

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Expansion of Intact Sensory-motor Territories in Proximal Neuraxial Lesions using Peripheral Nerve-muscle Weeding Interventions

Adiga

2024

Explor Res Hypothesis Med

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Following complete peripheral nerve injury, collateral sprouting (CS) by adjacent nerves causes concentric shrinkage of the insensate area. Such take-over of insensate territory is unknown in proximal lesions such as stroke, spinal cord injury, and cauda equina syndrome, as peripheral nerves supplying insensate territories still maintain continuity from the cell body in the dorsal root ganglion (DRG) to the skin innervation territory. This preserved distal continuity opposes territory take-over by the expansion of adjacent sensate territories; sectioning peripheral nerves in insensate territories distal to DRGs disconnects nerve cell bodies from their skin territory, thus facilitating sensate territory expansion of adjacent nerves. Similar motor system applications in paralyzed territories include lower motor neurone lesioning and fasciectomies, facilitating motor territory expansion of adjacent nerves through CS. A search for evidence of previous conception of these hypotheses was conducted in the literature, using a combination of relevant terms from three categories (proximal neuraxial lesions, nerve-muscle interventions, collateral sprouting); however, this yielded no pertinent results, suggesting that these concepts are novel. Observations from the literature on peripheral nerve injury indicate a sound scientific basis for these hypotheses. Therefore, the suggested "weeding" interventions are likely to succeed in minimizing neurological deficits and improving patients' quality of life. Various interventions to expand sensory/motor territories are considered; these include nerve lesioning distal to DRGs and removing fascial barriers between innervated and paralyzed muscles. Experience from such interventions will help expand our understanding of the speed and extent of CS-mediated neurological recovery as well as brain's plastic abilities in reorienting after such procedures.

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Section: Evaluation Of the Hypothesesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expansion of Intact Sensory-motor Territories in Proximal Neuraxial Lesions using Peripheral Nerve-muscle Weeding Interventions

Adiga

2024

Explor Res Hypothesis Med

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“…There are two possible ways for IANs to recover from injury, one is through the regeneration of nerve fibers after Wallerian degeneration, and the other is the collateral reinnervation by means of ingrowth from adjacent intact nerves [32]. Some scholars believed that laser therapy exerts its effect by increasing the release of a trophic factor within the area being treated and then stimulating colateral reinnervation from the other nonreactive adjacent tissues [46][47][48]. Others proposed the possible mechanisms of laser radiation on neurosensory regeneration related with the reduction of prostaglandins, acute phase inflammatory factors like TNF-α, IL-1 and interstitial metalloproteinase [49] and the synthesis of growth factors [50].…”

Section: Plos Onementioning

confidence: 99%

The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis

Yang

Chen

et al. 2023

PLoS ONE

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Objective The aim of this META-analysis was to evaluate the efficacy of photobiomodulation (PBM) therapy in the treatment of inferior alveolar nerve (IAN) injury due to orthognathic surgeries, extraction of impacted third molars and mandibular fractures. Methods and materials A electric search was conducted by a combination of manual search and four electric databases including Pubmed, Embase, Cochrane library and Web of Science, with no limitation on language and publication date. Gray literature was searched in ClinicalTrials.gov and googlescholar. All retrieved articles were imported into ENDNOTE software (version X9) and screened by two independent reviewers. All analysis was performed using the REVMAN software (version 5.3) Results Finally, 15 randomized controlled trials met the inclusion criteria for qualitative analysis and 14 for META-analysis from 219 articles. The results showed that PBM therapy had no effect on nerve injury in a short period of time (0-48h, 14 days), but had significant effect over 30 days. However, the effect of photobiomodulation therapy on thermal discrimination was still controversial, most authors supported no significant improvement. By calculating the effective rate of PBM, it was found that there was no significant difference in the onset time of treatment, whether within or over 6 months. Conclusions The results of this META-analysis show that PBM therapy is effective in the treatment of IAN injures no matter it begins early or later. However, due to the limited number of well-designed RCTs and small number of patients in each study, it would be necessary to conduct randomized controlled trials with large sample size, long follow-up time and more standardized treatment and evaluation methods in the future to provide more accurate and clinically meaningful results.

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Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury

Chen,

Zhang,

Zhang

et al. 2024

Chin. J. Integr. Med.

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New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury

Cited by 8 publications

References 12 publications

Expansion of Intact Sensory-motor Territories in Proximal Neuraxial Lesions using Peripheral Nerve-muscle Weeding Interventions

Expansion of Intact Sensory-motor Territories in Proximal Neuraxial Lesions using Peripheral Nerve-muscle Weeding Interventions

The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis

Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury

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