Abstract:Abstract:Nuclear receptor (NR) target genes have key roles in cellular metabolism, cellular growth and differentiation and in controlling inflammation. Many NR target genes are also involved in dysregulated pathways that can lead to common human diseases, such as type 2 diabetes, atherosclerosis, Alzheimer's disease and cancer. On the genomic level these pathways converge on regulatory modules, some of which contain co-localizing NR binding sites, so-called response elements (REs). Recent advances in genomic t… Show more
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