The primary objective of this study is the development of an integrated framework for sustainable development in agri-food Small and Medium Enterprises (SMEs) with a variety of production types. Dealing with the significant research problem of defining a successful record-keeping system, as this is the foundation of an integrated information framework in agri-food SMEs, this research identifies and explicates the several conceptual, methodological, organizational, and technical concerns related to the data collection, processing, and recording, as well as information generation in agri-food SMEs. Two main fields of research are distinguished: the micro-level, which is related to the monitoring of agri-food SMEs, and the macro-level, which relates to the collection, processing, and collective interpretation of different types of data. The findings show how the creation of a database for all levels of analysis, primarily business analyses, followed by an analysis of the development of the agri-food sector, as a whole and by individual regions and branches, etc., constitutes the basis for the effective operation and ongoing improvement of an integrated framework for the sustainable development of agri-food SMEs. Methodologically, this study employs the system approach, system analysis, and synthesis sequence to produce business, economic, and social findings of theoretical and practicable worth to scholars, executives, and decision makers.