PM2.5 has attracted widespread attention since the public has become aware of it, while attention to PM10 has started to wane. Considering the significance of PM10, this study takes PM10 as the research object and raises a significant question: when will the influence of PM10 on public health end? To answer the abovementioned question, two promising research areas, i.e., air pollution forecasting and health effects analysis, are employed, and a novel hybrid framework is developed in this study, which consists of one effective model and one evaluation model. More specifically, this study first introduces one advanced optimization algorithm and cycle prediction theory into the grey forecasting model to develop an effective model for multistep forecasting of PM10, which can achieve reasonable forecasting of PM10. Then, an evaluation model is designed to evaluate the health effects and economic losses caused by PM10. Considering the significance of providing the future impact of PM10 on public health, we extend our forecasting results to evaluate future changes in health effects and economic losses based on our proposed health economic losses evaluation model. Accordingly, policymakers can adjust current air pollution prevention plans and formulate new plans according to the results of forecasting, evaluation and early-warning. Empirical research shows that the developed framework is applicable in China and may become a promising technique to enrich the current research and meet the requirements of air quality management and haze governance.