New intravenous sedative combinations in oral surgery: A comparative study of nalbuphine or pentazocine with midazolam

Hook, P.C.G.; Lavery, K.M.

doi:10.1016/0266-4356(88)90002-2

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…[ 18 ] in their study found that efficacy of postoperative analgesia was significantly superior for Nalbuphine (20 mg) than pentazocine (30 mg) on intramuscular injection. Hook and Lavery[ 19 ] compared the analgesic efficacy of nalbuphine (0.2 mg/kg) with midazolam, and they found that patients in nalbuphine group were more pain-free as compared to pentazocine.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of efficacy of preoperative nalbuphine hydrochloride and pentazocine lactate on hemodynamic response to tracheal intubation and postoperative analgesia

Sadafule¹,

Karhade²

2018

Anesth Essays Res

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Background:For General anaesthesia perioperative administration of opioids are choice of drugs to attenuate intubation response and to provide good intraoperative and postoperative analgesia. Mixed agonist-antagonist opioids produces powerful analgesia without undesirable side effects.Aim:Aim of present study to compare efficacy of Nalbuphine and Pentazocine on hemodynamic response to tracheal intubation and postoperative analgesia.Settings:Present study carried out in operation theater.Design:This is prospective randomized double blind controlled trial.Material and Methods:Patients of ASA physical status I and II, age 20-60 years undergoing abdominal surgical procedure of 1-2 hour duration were randomly divided into two groups of 30 patients each (Group N) receiving nalbuphine 0.3 mg.kg-1 and (Group P) receiving pentazocine 0.6 mg.kg-1 intravenously before induction. Baseline vital parameters were noted and then noted till 15 minutes after intubation to see hemodynamic response. Time of rescue analgesia required was noted postoperatively.Stastical Analysis:Chi-square test, paired and unpaired t-test were used for statistical analysis.Results:There is rise in heart rate, blood pressure after intubation in both groups but rise was more with Pentazocine as compared to Nalbuphine (P < 0.05). Postoperatively within 30 minutes 60% of patient from Pentazocine group require rescue analgesia compare to only 16.60% of patient of Nalbuphine group (P = 0.05) which is highly significant.Conclusion:Nalbuphine is potent mixed opioid analgesic which can be used for attenuation of pressor response of tracheal intubation and for perioperative analgesia with minimal side effects.

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Section: Discussionmentioning

confidence: 99%