New Inventions

McCullagh, McKim

doi:10.1016/s0140-6736(55)90272-5

Cited by 1 publication

(1 citation statement)

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“…The ability of normal spleen cells t o reverse the NIP-specific tolerance brought about by NIPI-CBA.MRBC contrasts with similar attempts t o reverse tolerance in the intact animal t o bovine gamma globulin 1431, sheep erythrocytes [44,45] and human gamma globulin [lo]. As recently discussed by Chiller and Weigle [lo], it is possible that in the cases where tolerance is not reversed, either the transferred cells fail t o localize in sufficient numbers in the recipient, or there remains enough tolerogen in the host to render the T cells tolerant, or a combination of the two processes is involved.…”

Section: Discussionmentioning

confidence: 90%

Hapten‐specific tolerance in mice. I. Induction with hapten‐coupled syngeneic erythrocytes

Hamilton¹,

Miller

1974

Eur J Immunol

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A specific suppression of the splenic anti-NIP (4-hydroxy-5-iodo-3-nitro-pheny1)acetyl plaque-forming cell response t o NIP. FGG (fowl IgG) was obtained in CBA/J mice by pretreatment with NIP-coated syngeneic erythrocytes. If the plaque assay was carried o u t at 7 days after challenge with NIP. FGG, a complete suppression of the indirect anti-NIP plaque-forming cell (PFC) response could be obtained, but there was no significant decrease in the direct anti-NIP PFC response at this stage. Complete suppression of the day 7 indirect PFC response occurred within 5-7 days after the NIPcoated erythrocyte treatment, and lasted for 1-2 months. The degree of suppression was found t o depend on the dose of the erythrocytes and on the amount of NIP coupled t o them. On closer examination of the anti-NIP PFC response at different time intervals after the NIP. FGG challenge, it became apparent that there was a slight increase in the indirect anti-NIP PFC response at days later than day 7. A definite suppression of the direct anti-NIP PFC cell response was observed earlier than a t day 7.The state of hapten-specific suppression could be reversed by the addition of syngeneic spleen cells at the time of antigen challenge. The suppression was found t o extend t o the serum anti-NIP antibody levels and could also be induced in animals previously primed with NIP-FGG.

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Section: Discussionmentioning

confidence: 90%