New investigations on the chemical behavior of 4-keto-1H-4,5-dihydro-1,2,5-benzotriazepines

Studies with 2‐arylhydrazononitriles: A novel simple, efficient route to 5‐acyl‐2‐substituted‐1,2,3‐triazol‐4‐amines

“…This was cyclized on reflux with acetic anhydride to yield diacylated dehydration products. At first glance we assumed formation of isoxazoles 6a in analogy to well established structures suggested for the products of cyclization of amidoximes in acid and base media [18]. However, we noted in 13 C NMR the presence of low field carbonyl carbon at 195.7 ppm.…”

Synthesis of novel 3,5,7‐triaryl‐5,6‐dihydro‐4h‐1,2,5‐triazepines

“…The 13 C NMR spectrum of 2b showed signals at 47. 5 The semi-empirical PM3 computations were performed with Hyperchem (version 7.5) at the RHF level. It was found that the total energy of 2a was E = -4948.6442 kcal/mol with Gradient 0.044.…”

“…The 1,2,5-triazepine system has received considerable attention in recent times [1][2][3], though it is less significant compared to the corresponding benzofused analogues [4,5]. Besides being used as immunomodulating agents [6], 1,2,5-triazepine derivatives are found to exhibit antifungal [7], anti-inflammatory, analgesic [8] and sedative activities [9].…”

2‐(Arylamino)aryliminophosphoranes from 2‐nitrodiarylamines

“…Compound 1m was obtained according to the known procedure . Orange fine crystals, mp: 103–106°C (ref.…”

“…Orange fine crystals, mp: 103–106°C (ref. ; mp: 108–111°C); 1 H NMR (500 MHz, CDCl 3 ): δ = 6.75 (dd, J = 9.1, 2.2 Hz, 1 H), 7.37–7.40 (m, 1 H), 7.49–7.56 (m, 2 H), 7.72–7.74 (m, 1 H), 7.21 (d, J = 2.2 Hz, 1 H), 7.80–7.89 (m, 2 H), 7.91–7.95 (m, 1 H), 8.19 (d, J = 9.1 Hz, 1 H), 9.69 (s, 1 H). 13 C NMR (125 MHz, CDCl 3 ): δ = 115.3, 118.1, 122.3, 123.6, 126.1, 127.0, 127.5, 127.8, 128.1, 130.0, 131.7, 134.0, 135.3, 142.5, 143.9.…”