New iron-oxide particles for magnetic nanoparticle hyperthermia: an<i>in-vitro</i>and<i>in-vivo</i>pilot study

Hedayati, Mohammad; Attaluri, Anilchandra; Bordelon, David E.; Goh, Robby Miguel; Armour, M.; Zhou, Haoming; Cornejo, Christine; Wabler, Michele; Zhang, Yonggang; DeWeese, Theodore L.; Ivkov, Robert

doi:10.1117/12.2019834

Cited by 17 publications

(26 citation statements)

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“…29 The crystals in the BNF core are parallelepiped shaped, 52 forming fractal aggregates, 53 and the JHU cores are irregularly shaped. 54 To understand the N eel and Brownian relaxation power loss contributions in Dartmouth MNP power loss mechanism, we measured the MNP spectra using a wide-band Electromagnetic induction sensor, developed by Geophex, Ltd. (Raleigh, NC, USA). The sensor is an active system and consists of two transmitters (Tx) and a vector receiver (Rx).…”

Section: B Nanoparticle Characterizationmentioning

confidence: 99%

“…A general treatment of the relaxation in ferrofluids based on a Fokker-Planck equation was given by Brown; 49 Rosensweig 40 used the effective relaxation time (1/s eff ¼ 1/s b þ 1/s n ) to calculate the power dissipation in a magnetic fluid under an AMF. The frequency dependence of relaxation of the MNP system can be determined experimentally by measuring the spectra of the complex susceptibility [50][51][52][53][54][55][56][57][58][59] or frequency dependent magnetic field responses from the MNPs.…”

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confidence: 99%

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Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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Magnetic nanoparticles (MNPs), referred to as the Dartmouth MNPs, which exhibit high specific absorption rate at low applied field strength have been developed for hyperthermia therapy applications. The MNPs consist of small (2-5 nm) single crystals of gamma-FeO with saccharide chains implanted in their crystalline structure, forming 20-40 nm flower-like aggregates with a hydrodynamic diameter of 110-120 nm. The MNPs form stable (>12 months) colloidal solutions in water and exhibit no hysteresis under an applied quasistatic magnetic field, and produce a significant amount of heat at field strengths as low as 100 Oe at 99-164 kHz. The MNP heating mechanisms under an alternating magnetic field (AMF) are discussed and analyzed quantitatively based on (a) the calculated multi-scale MNP interactions obtained using a three dimensional numerical model called the method of auxiliary sources, (b) measured MNP frequency spectra, and (c) quantified MNP friction losses based on magneto-viscous theory. The frequency responses and hysteresis curves of the Dartmouth MNPs are measured and compared to the modeled data. The specific absorption rate of the particles is measured at various AMF strengths and frequencies, and compared to commercially available MNPs. The comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe). This may extend MNP hyperthermia therapy to deeper tumors that were previously non-viable targets, potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.

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Section: B Nanoparticle Characterizationmentioning

confidence: 99%

mentioning

confidence: 99%

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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“…These crystals were aggregated under high-energy conditions leading to controlled aggregates forming nanoparticle cores comprising 5–9 parallelepipeds that exhibit a collective magnetic state leading to particles exhibiting significant uniaxial anisotropy and thus enhanced heating with AMFs [29–31]. Interestingly, once coated with polysaccharides (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, Hedayati et al [29] have described methods and particle synthesis based on high-gravity controlled precipitation and subsequent hydrothermal processing to produce MNP constructs having reduced uniaxial anisotropy while still retaining significant magnetic properties at saturation to enable heating at clinically relevant magnetic field conditions [7,29]. MNP constructs designed for heating, as described above are generally not characterised for their MR imaging contrast, and conspicuously absent are comparisons with formulations designed for MRI contrast.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging contrast of iron oxide nanoparticles developed for hyperthermia is dominated by iron content

Wabler¹,

Zhu²,

Hedayati³

et al. 2014

International Journal of Hyperthermia

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Purpose Magnetic iron oxide nanoparticles (MNPs) are used as contrast agents for magnetic resonance imaging (MRI) and hyperthermia for cancer treatment. The relationship between MRI signal intensity and cellular iron concentration for many new formulations, particularly MNPs having magnetic properties designed for heating in hyperthermia, is lacking. In this study, we examine the correlation between MRI T2 relaxation time and iron content in cancer cells loaded with various MNP formulations. Materials and methods Human prostate carcinoma DU-145 cells were loaded with starch-coated bionised nanoferrite (BNF), iron oxide (Nanomag® D-SPIO), Feridex™, and dextran-coated Johns Hopkins University (JHU) particles at a target concentration of 50 pg Fe/cell using poly-D-lysine transfection reagent. T2-weighted MRI of serial dilutions of these labelled cells was performed at 9.4 T and iron content quantification was performed using inductively coupled plasma mass spectrometry (ICP-MS). Clonogenic assay was used to characterise cytotoxicity. Results No cytotoxicity was observed at twice the target intracellular iron concentration (~100 pg Fe/cell). ICP-MS revealed highest iron uptake efficiency with BNF and JHU particles, followed by Feridex and Nanomag-D-SPIO, respectively. Imaging data showed a linear correlation between increased intracellular iron concentration and decreased T2 times, with no apparent correlation among MNP magnetic properties. Conclusions This study demonstrates that for the range of nanoparticle concentrations internalised by cancer cells the signal intensity of T2-weighted MRI correlates closely with absolute iron concentration associated with the cells. This correlation may benefit applications for cell-based cancer imaging and therapy including nanoparticle-mediated drug delivery and hyperthermia.

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“…In practice, however, the spatial heterogeneity of AMF is inevitable and significant for coil of certain shape. The solenoid coil commonly used for AMF generates a relatively uniform field only in the middle-section of the coil, whereas a Helmholtz type coil 38 …”

Section: Discussionmentioning

confidence: 99%

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

et al. 2013

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Purpose:To propose an alternative method of thermoacoustic wave generation based on heating of magnetic nanoparticles (MNPs) using alternating magnetic field (AMF). Methods: The feasibility of thermoacoustic wave generation from MNPs by applying a short-burst of AMF or a frequency-modulated AMF is theoretically analyzed. As the relaxation of MNPs is strongly dependent upon the amplitude and frequency of AMF, either an amplitude modulated, fixed frequency AMF (termed time-domain AMF) or a frequency modulated, constant amplitude AMF (termed frequency-domain AMF) will result in time-varying heat dissipation from MNPs, which has the potential to generate thermoacoustic waves. Following Rosensweig's model of specific power loss of MNPs in a steady-state AMF, the time-resolved heat dissipations of MNPs of superparamagnetic size when exposed to a short bursting of AMF and/or to a linearly frequency chirped AMF are derived, and the resulted acoustic propagation is presented. Based on experimentally measured temperaturerise characteristics of a superparamagnetic iron-oxide nanoparticle (SPION) matrix in a steady-state AMF of various frequencies, the heat dissipations of the SPION under time-domain and frequencydomain AMF configurations that could have practical utility for thermoacoustic wave generation are estimated. Results:The initial rates of the temperature-rise of the SPION matrix were measured at an ironweight concentration of 0.8 mg/ml and an AMF frequency of 88.8 kHz to 1.105 MHz. The measured initial rates of temperature-rise were modeled by Rosensweig's theory, and projected to 10 MHz AMF frequency, at which a 1 μs bursting corresponding to a 1.55 mm axial resolution of acoustic detection could contain 10 complete cycles of AMF oscillation and the power dissipation is approximately 84 times of that at 1 MHz. Exposing the SPION matrix to a 1 μs bursting of AMF at 10 MHz frequency and 100 Oe field intensity would produce a volumetric heat dissipation of 7.7 μJ/cm 3 over the microsecond duration of the AMF burst. If the SPION matrix is exposed to a 1 ms long AMF train at 100 Oe field intensity that chirps linearly from 1 to 10 MHz, the volumetric heat dissipation produced over each 2π phase change of the AMF oscillation is estimated to increase from 0.15 to 1.1 μJ/cm 3 within the millisecond duration of the chirping of AMF. Conclusions: The heat dissipations upon SPION (∼1 mg/ml iron-weight concentration) by a 1 μs bursting of 100 Oe AMF at 10 MHz and a 1 ms train of 100 Oe AMF that chirps linearly from 1 to 10 MHz were estimated to determine the potential of thermal-acoustic wave generation. Although thermoacoustic wave generation from MNPs by time-or frequency-domain AMF applications is predicted, the experimental generation of such a wave remains challenging. © 2013 American Association of Physicists in Medicine. [http://dx

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New iron-oxide particles for magnetic nanoparticle hyperthermia: anin-vitroandin-vivopilot study

Cited by 17 publications

References 0 publications

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Magnetic resonance imaging contrast of iron oxide nanoparticles developed for hyperthermia is dominated by iron content

Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis

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