New Iron Reagents for Alkaline Solutions

Nilsson, Gustav

doi:10.1038/157550b0

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“…Cuprizone 1 has been first described in 1946 as a metal ion chelator, which is able to interact with various transition metal ions showing a high specificity for copper ions even at low concentration . Since then, it has been used for the determination of trace copper content within metals and alloys .…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

Fries

Mertens

Teske³

et al. 2019

ACS Omega

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The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

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Section: Introductionmentioning

confidence: 99%