New isoflavones and bioactive constituents from the fruits of Psoralea corylifolia

Chen, J; Chen, C; Lai, Rong-Mao; Chen, H; Kuo, Wei‐Wen; Liao, Tougen

doi:10.1055/s-0031-1282523

Cited by 4 publications

(7 citation statements)

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“…Anticancer (Hao et al, ), antioxidant (Chen et al, ), anti‐Alzheimer (Somani et al, ), Collagengenesis (Xu et al, )…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…The dried fruits of the plant was investigated, and n‐hexane‐ and EtOAc‐soluble fractions have resulted in purification of two new isoflavones, 7‐O‐methylcorylifol A and 7‐O‐isoprenylcorylifol A, along with eight known compounds, including psoralen, angelicin, bavachalcone, 13‐dihydro‐12,13‐epoxybakuchiol, bakuchiol, 12, p‐hydroxybenzaldehyde, stigmasterol, and b‐sitosterol (Chen et al, ; Figure ).…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

“…One of the isolated compound, psoralen showed the promising antioxidant activity (IC 50 value = 1.10 ± 0.60 μg/ml) against the superoxide anion production by human neutrophils in response to formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine/cytochalasin B (fMLP/CB; Chen et al, ).…”

Section: Biological Activitiesmentioning

confidence: 99%

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Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Alam

Khan

Asad

2017

Phytotherapy Research

137

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Psoralea corylifolia L. (Leguminosae) is a well-known traditional medicinal plant used from ancient times for treatment of various ailments. It is widely distributed and an important part of therapeutics in Ayurveda and in Chinese medicines. The aim of this review is to present comprehensive and most up to date report on its ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects. Studies on the ethnobotanical, ethnopharmacological, clinical, phytochemical, and side effects of P. corylifolia were published until year 2017 and were searched using various scientific databases. The scientific literature searched revealed that these plant species has been extensively investigated in vivo and in vitro for various biological and phytochemical studies. It has cardiotonic, vasodilator, pigmentor, antitumor, antibacterial, cytotoxic, and anti-helminthic properties and locally used for alopecia, inflammation, leukoderma, leprosy, psoriasis, and eczema. So far, about a hundred bioactive compounds have been isolated from seeds and fruits, and most important compounds identified belongs to coumarins, flavonoids, and meroterpenes groups. This review article summarized the most updated scientific literature on bioactive phytochemical and biological activities of P. corylifolia. This article will be a useful addition to providing information for future research, and more standard clinical trials are needed for the plant to be used as therapeutic agent.

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“…Anticancer (Hao et al, ), antioxidant (Chen et al, ), anti‐Alzheimer (Somani et al, ), Collagengenesis (Xu et al, )…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

Section: Phytochemical Constituentsmentioning

confidence: 99%

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Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Alam

Khan

Asad

2017

Phytotherapy Research

137

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Section: Introductionmentioning

confidence: 99%

“…Major chemical constituents are psoralen, bakuchiol, bakuchicin, and minor phytoconstituents angelicin, psoralidin, bavachromanol, 7-O-methylbavachin, psoralidin oxide [2]. Seed oil contains glycerides of oleic acid, steric acid, palmitic acid, myristic acid, myristoleic acid, lenoleic acid, along with stigmasterol and b-sitosterol [7]. Lipopolysaccharide (LPS) is the principal constituent of cell walls of Gram-negative bacteria and can induce acute inflammatory response by triggering the release of a large number of inflammatory cytokines in different types of cells [8].…”

Section: Introductionmentioning

confidence: 99%

Extraction, Quantification, and Cytokine Inhibitory Response of Bakuchiol in Psoralea coryfolia Linn.

et al. 2020

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(1) Background: The present investigation studies the optimization of extraction, quantification, and cytokine inhibitory effects bakuchiol (BKL) in Psoralea coryfolia Linn. (2) Methods: The seeds of Psoralea coryfolia cleaned, dried, and powdered. Different separation methods maceration, reflux, Soxhlet, and ultrasonic assisted extraction (UAE) were employed for the isolation of BKL by five pure solvents. The quantity of BKL was measured by high-performance liquid chromatography (HPLC) method to determine the highest yield percentage. The effect of optimized BKL was then tested in an animal model of sepsis induced by lipopolysaccharides (LPS). (3) Results: The UAE method was found to be the best among tested separation methods and yielded highest percentage of BKL in petroleum ether extract. Septic rats showed a significant elevation in levels of biochemical markers like AST, ALT, ALP, BIL, SCr, and BUN in plasma. Proinflammatory cytokines (TNF-α and IL-1) levels were also increased in LPS-induced animals. BKL has been found to significantly reverse these elevated levels as compared to the LPS-induced animals. (4) Conclusion: The present results suggest that BKL has positive effects when administered in animals with pathogenic shock by decreasing the circulating levels of biomarkers. Further studies are necessary to explore the clinical implications of such findings.

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Phytochemical and Pharmacological Aspects of Psoralen – A Bioactive Furanocoumarin fromPsoralea corylifoliaLinn.

Tripathi,

Bhardwaj,

Kumar

et al. 2023

Chemistry & Biodiversity

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Since long ago, medicinal plants have played a vital role in drug discovery. Being blessed and rich in chemovars with diverse scaffolds, they have unique characteristics of evolving based on the need. The World Health Organization also mentions that medicinal plants remain at the center for meeting primary healthcare needs as the population relies on them. The plant‐derived natural products have remained an attractive choice for drug development owing to their specific biological functions relevant to human health and also the high degree of potency and specificity they offer. In this context, one such esteemed phytoconstituent with inexplicable biological potential is psoralen, a furanocoumarin. Psoralen was the first constituent isolated from the plant Psoralea corylifolia, commonly known as Bauchi. Despite being a life‐saver for psoriasis, vitiligo, and leukoderma, it also showed immense anticancer, anti‐inflammatory, and anti‐osteoporotic potential. This review brings attention to the possible application of psoralen as an attractive target for rational drug design and medicinal chemistry. It discusses the various methods for the total synthesis of psoralen, its extraction, the pharmacological spectrum of psoralen, and the derivatization done on psoralen.

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New isoflavones and bioactive constituents from the fruits of Psoralea corylifolia

Cited by 4 publications

References 0 publications

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review

Extraction, Quantification, and Cytokine Inhibitory Response of Bakuchiol in Psoralea coryfolia Linn.

Phytochemical and Pharmacological Aspects of Psoralen – A Bioactive Furanocoumarin fromPsoralea corylifoliaLinn.

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