New Isopropyl Chromone and Flavanone Glucoside Compounds from the Leaves of <i>Syzygium cerasiforme</i> (Blume) Merr. &amp; L.M.Perry and Their Inhibition of Nitric Oxide Production

Ninh, Bui Hai; Dung, Dương Thị; Tài, Bùi Hữu; Yến, Phạm Hải; Nhiệm, Nguyễn Xuân; Hien, Truong Thi Thu; Trang, Đỗ Thị; Tuyen, Nguyen Van; Anh, Le Tuan; Hoài, Nguyễn Thị; Kiệm, Phan Văn

doi:10.1002/cbdv.202201048

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…The anti-inflammatory activity of this new chromone was evaluated, and it was concluded that it inhibits NO production in LPS-activated RAW264.7 cells with an IC 50 value of 12.28 ± 1.15 μM, compared to a positive control, N Gmonomethyl-L-arginine acetate, which presents an IC 50 value of 32.50 ± 1.00 μM. 35 Abronia nana (Nyctaginaceae) is an ornamental plant that inhabits the desert area of North America whose pharmacological potential is not yet well-established. Following on from previous studies, carried out to find antisepsis lead compounds from natural sources, Lee and colleagues isolated a new Cmethylcoumarinochromone from Abronia nana suspension cultures.…”

Section: Aquilaria Sinensismentioning

confidence: 99%

“…and L.M. Perry, a plant used in Vietnam in folk medicine . Its structure was elucidated as 5,7-dihydroxy-2-isopropyl-6,8-dimethyl-4 H -chromen-4-one ( 48 , Figure ) by the analysis of HR-ESI-MS, NMR, and ECD spectral data.…”

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

“…Perry, a plant used in Vietnam in folk medicine. 35 Its structure was elucidated as 5,7-dihydroxy-2-isopropyl-6,8-dimethyl-4 H -chromen-4-one ( 48 , Figure 8 ) by the analysis of HR-ESI-MS, NMR, and ECD spectral data. The anti-inflammatory activity of this new chromone was evaluated, and it was concluded that it inhibits NO production in LPS-activated RAW264.7 cells with an IC 50 value of 12.28 ± 1.15 μM, compared to a positive control, N G -monomethyl- l -arginine acetate, which presents an IC 50 value of 32.50 ± 1.00 μM.…”

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

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Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in a continuous search for lead structures that can be used as models for the development of new medicines by the pharmaceutical industry. Chromone and chromanones are recognized as privileged structures and useful templates for the design of diversified therapeutic molecules with potential pharmacological interest. Chromones and chromanones are widely distributed in plants and fungi, and significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., have been reported for these compounds, suggesting their potential as lead drug candidates. This review aims to update the literature published over the last 6 years (2018–2023) regarding the natural occurrence and biological activity of chromones and chromanones, highlighting the recent findings and the perspectives that they hold for future research and applications namely in health, cosmetic, and food industries.

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Section: Aquilaria Sinensismentioning

confidence: 99%

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

See 2 more Smart Citations

Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production

Van Kiem,

Hai Ninh,

Huu Tai

et al. 2023

Chemistry & Biodiversity

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Four undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5‐17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)‐gaylussacin (1), 6ʹʹ‐O‐galloylgaylussacin sodium salt (2), 6ʹʹ‐O‐galloylgaylussacin (3), 4ʹ‐O‐[β‐D‐glucopyranosyl‐(1→6)‐glucopyranosyl]oxy‐2ʹ‐hydroxy‐6ʹ‐methoxydihydrochalcone (4), gaylussacin (5), pinosilvin 3‐O‐β‐D‐glucopyranoside (6), myricetin‐3‐O‐(2ʹʹ‐O‐galloyl)‐α‐L‐rhamnopyranoside (7), myricetin‐3‐O‐(3ʹʹ‐O‐galloyl)‐α‐L‐rhamnopyranoside (8), myricetin‐3‐O‐α‐L‐rhamnopyranoside (9), quercitrin (10), myricetin‐3‐O‐β‐D‐glucopyranoside (11), myricetin‐3‐O‐β‐D‐galactopyranoside (12), quercetin 3‐O‐α‐L‐arabinopyranoside (13), myricetin‐3‐O‐2ʹʹ‐O‐galloyl)‐α‐L‐arabinopyranoside (14), (+)‐gallocatechin (15), (‐)‐epigallocatechin (16), and 3,3’,4’‐trimethoxyellagic acid 4‐O‐β‐D‐glucopyranoside (17) by the analysis of HRESIMS, 1D and 2D NMR spectra in comparison with the previously reported data. Compounds 1‐3, 5, and 6 significant inhibition of NO production in LPS‐activated RAW264.7 cells, with IC50 values ranging from 18.37 ± 1.38 to 35.12 ± 2.53 µM, compared to a positive control (dexamethasone) with an IC50 value of 15.37 ± 1.42 µM.

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Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells

Thuy,

Hoa,

Linh

et al. 2023

Chemistry & Biodiversity

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Gnetum latifolium var. funiculare Markgr. is a medicinal plant and widely distributed in mountainous areas of Vietnam. Phytochemical investigation on the trunks of this plant afforded eight stilbene derivatives (1‐8) including for new compounds (1‐4). Their structures were determined based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR spectra. Among the isolates, compounds 1‐3 showed moderate NO production inhibition in LPS‐activated RAW264.7 cells with the IC50 values ranging from 46.81 to 68.10 μM, compounds 4 and 6 showed weak effects with the IC50 values of 96.57 and 79.46 μM, respectively, compared to that of the positive control compound, dexamethasone (IC50 14.20 μM).

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New Isopropyl Chromone and Flavanone Glucoside Compounds from the Leaves of Syzygium cerasiforme (Blume) Merr. & L.M.Perry and Their Inhibition of Nitric Oxide Production

Cited by 4 publications

References 22 publications

Biological and Medicinal Properties of Natural Chromones and Chromanones

Biological and Medicinal Properties of Natural Chromones and Chromanones

Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production

Four New Stilbene Derivatives Isolated from Gnetum latifolium var. funiculare Markgr. and Their Inhibition of NO Production in LPS‐activated RAW264.7 Cells

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