The Cenozoic deformation history of Central Iran has been dominantly accommodated by the activation of major intracontinental strike‐slip fault zones, developed in the hinterland domain of the Arabia‐Eurasia convergent margin. Few quantitative temporal and kinematic constraints are available from these strike‐slip deformation zones, hampering a full assessment of the style and timing of intraplate deformation in Iran and the understanding of the possible linkage to the tectonic reorganization of the Zagros collisional zone. This study focuses on the region to the north of the active trace of the sinistral Doruneh Fault. By combing structural and low‐temperature apatite fission track (AFT) and (U‐Th)/He (AHe) thermochronology investigations, we provide new kinematic and temporal constraints to the deformation history of Central Iran. Our results document a post‐Eocene polyphase tectonic evolution dominated by dextral strike‐slip tectonics, whose activity is constrained since the early Miocene in response to an early, NW‐SE oriented paleo‐σ1 direction. A major phase of enhanced cooling/exhumation is constrained at the Miocene/Pliocene boundary, caused by a switch of the maximum paleo‐σ1 direction to N‐S. When integrated into the regional scenario, these data are framed into a new tectonic reconstruction for the Miocene‐Quaternary time lapse, where strike‐slip deformation in the intracontinental domain of Central Iran is interpreted as guided by the reorganization of the Zagros collisional zone in the transition from an immature to a mature stage of continental collision.