New Lactobacillus plantarum membrane proteins (LpMPs) towards oral anti-inflammatory agents against dextran sulfate sodium-induced colitis

Han, Hua; Liu, Lu; Zhang, Jieping; Zhang, Meng; Chen, Xinyu; Huang, Yu‐Yuan; Ma, Wen‐Xiu; Qin, Huanlong; Shen, Li; Zhang, Jundong; Yang, Wen-sheng

doi:10.1016/j.intimp.2022.109416

Cited by 1 publication

(1 citation statement)

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“…Studies have shown that extracellular polysaccharides and membrane proteins extracted from L. plantarum can improve intestinal barrier function and alleviate colitis. , In addition to the intracellular metabolic production of probiotics, recent studies have revealed that their extracellular metabolic production also serves a variety of probiotic functions. Several studies have shown that I3C, ILA, and IAA produced by Lactobacillus metabolism of Trp have the efficacy of maintaining intestinal mucosal barrier, immune regulation, and antitumor effect. ,,, In our previous study, S164 was found to produce ILA by metabolizing Trp in vitro .…”

Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus plantarum-Derived Indole-3-lactic Acid Ameliorates Intestinal Barrier Integrity through the AhR/Nrf2/NF-κB Axis

Wang,

Guan,

Wang

et al. 2024

J. Agric. Food Chem.

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Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2related factor 2 (Nrf2) signaling pathways and promoting tight junction protein expression. This study further explored the crucial substances of L. plantarum DPUL-S164 in alleviating intestinal barrier damage in mice through a dextran sodium sulfate-induced ulcerative colitis mouse model. Compared to dead L. plantarum DPUL-S164 (D-S164), live L. plantarum DPUL-S164 (S164) and its tryptophan metabolite, ILA, showed an effective ameliorating effect on the intestinal barrier injury of mice treated by antibiotic cocktail and sodium dextran sulfate, suggesting that the crucial substances of L. plantarum DPUL-S164 ameliorating intestinal barrier injury are its extracellular metabolites. Furthermore, S164 and its tryptophan metabolite, ILA, ameliorate intestinal barrier injury and suppress intestinal inflammation by activating the AhR−Nrf2 pathway and inhibiting the nuclear factor kappa-B (NF-κB) pathway. These results suggest that L. plantarum DPUL-S164 ameliorates intestinal epithelial barrier damage in mice, primarily by producing ILA as a ligand to activate the AhR pathway.

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