New light on treatment of cervical cancer: Chinese medicine monomers can be effective for cervical cancer by inhibiting the PI3K/Akt signaling pathway

Liu, Fangyuan; Xu, Jiayue; Yang, Rui; Liu, Shaoxuan; Hu, Siya; Yan, Meng-Yu; Han, Feng-Juan

doi:10.1016/j.biopha.2022.114084

Cited by 14 publications

(7 citation statements)

References 94 publications

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“…The PI3K/Akt signaling pathway is a key pathway for regulating tumorigenesis, development, proliferation, and metastasis [ 35 ]. As a key regulator of tumor development, the PI3K/Akt pathway has become a potential target for traditional Chinese medicine therapy [ 36 ]. The activation of proteins associated with this pathway promotes the progression of osteosarcoma [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro

Deng

Wang

et al. 2023

Biomedicines

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Osteosarcoma is an aggressive malignant neoplasm, and it is of great significance to the fabrication and investigation of the anti-tumor mechanism of nanomedicine in the treatment of osteosarcoma. Herein, a cinnamaldehyde polymeric prodrug micelle with pH-sensitive charge-conversion ability (mPEG-b-P(C7-co-CA)) was fabricated, and the anti-osteosarcoma mechanism of mPEG-b-P(C7-co-CA) micelle was investigated. mPEG-b-P(C7-co-CA) micelles were prepared by self-assembly method, and their diameter was 227 nm. mPEG-b-P(C7-co-CA) micelles could regulate the cell cycle and inhibit the proliferation of 143B cells, which was demonstrated by flow cytometry analysis, CCK-8 assay and 5-Ethynyl-2′-deoxyuridine (EdU) staining. The wound-healing assay and transwell assay showed that mPEG-b-P(C7-co-CA) micelles effectively inhibited the migration and invasion of 143B cells. It was proven that mPEG-b-P(C7-co-CA) micelles downregulated the levels of proliferation and apoptosis-related proteins and affected osteosarcoma migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT). In addition, mPEG-b-P(C7-co-CA) micelles can also inhibit the transcriptional activity of the PI3K/Akt signaling pathway. Therefore, these findings provide new evidence for the pharmacological effects of mPEG-b-P(C7-co-CA) micelles.

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Section: Resultsmentioning

confidence: 99%

A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro

Deng

Wang

et al. 2023

Biomedicines

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“…The rational use of active ingredients in TCM to develop new drugs is a reasonable and rapid way to develop new drugs. [103,104] In this era of data, this study lists relevant traditional Chinese medicine monomers for the treatment of GA through literature management. Simultaneously, the prospects and key targets of GA drug development were prospected.…”

Section: Discussionmentioning

confidence: 99%

“…The rational use of active ingredients in TCM to develop new drugs is a reasonable and rapid way to develop new drugs. [ 103 , 104 ]…”

Section: Discussionmentioning

confidence: 99%

Exploring effect of herbal monomers in treating gouty arthritis based on nuclear factor-kappa B signaling: A review

Guo,

Ye,

Tang

et al. 2024

Medicine

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Gouty arthritis (GA) is an inflammatory disease caused by disorders of the purine metabolism. Although increasing number of drugs have been used to treat GA with the deepening of relevant research, GA still cannot be cured by simple drug therapy. The nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in the pathogenesis of GA. A considerable number of Chinese herbal medicines have emerged as new drugs for the treatment of GA. This article collected relevant research on traditional Chinese medicine monomers in the treatment of GA using NF-κB, GA, etc. as keywords; and conducted a systematic search of relevant published articles using the PubMed database. In this study, we analyzed the therapeutic effects of traditional Chinese medicine monomers on GA in the existing literature through in vivo and in vitro experiments using animal and cell models. Based on this review, we believe that traditional Chinese medicine monomers that can treat GA through the NF-κB signaling pathway are potential new drug development targets. This study provides research ideas for the development and application of new drugs for GA.

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“…The development of active pharmaceutical ingredients in individual TCM is a fast way to develop a new class of drugs. [ 120 , 121 ] In the era of big data, we list the herbal monomers related to DR in the form of literature management. We also present the prospects of exploiting secondary drugs and new applications of old drugs, as well as the key targets for developing new drugs with potential to treat DR. Consequently, we consider that the key to modernization of TCM is the development of drugs that can satisfy the clinical treatment needs of DR.…”

Section: Discussionmentioning

confidence: 99%

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Hu,

Wang,

et al. 2023

Medicine

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Diabetic retinopathy (DR) has become one of the top 3 blinding eye diseases in the world. In spite of recent therapeutic breakthroughs, it is not yet possible to cure DR through pharmacotherapy. Cell death is thought to play a key role in the pathogenesis of DR. Moderate modulation of cellular autophagy and inhibition of apoptosis have been identified as effective targets for the treatment of DR. Numerous phytochemicals have emerged as potential new drugs for the treatment of DR. We collected basic DR research on herbal monomers through keywords such as autophagy and apoptosis, and conducted a systematic search for relevant research articles published in the PubMed database. This review provides the effects and reports of herbal monomers on various DR cellular and animal models in vivo and in vitro in the available literature, and emphasizes the importance of cellular autophagy and apoptosis as current DR therapeutic targets. Based on our review, we believe that herbal monomers that modulate autophagy and inhibit apoptosis may be potentially effective candidates for the development of new drugs in the treatment of DR. It provides a strategy for further development and application of herbal medicines for DR treatment.

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New light on treatment of cervical cancer: Chinese medicine monomers can be effective for cervical cancer by inhibiting the PI3K/Akt signaling pathway

Cited by 14 publications

References 94 publications

A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro

A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro

Exploring effect of herbal monomers in treating gouty arthritis based on nuclear factor-kappa B signaling: A review

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

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