New long-acting injectable microcapsule contraceptive system

Microspheres of Biodegradable Block Copolymer for Long-Acting Controlled Delivery of Contraceptives

“…Microspheres containing Norgestrel (MCN) were prepared by the solvent-evaporation process introduced by N.R Beck et al 3 with some modifications.…”

“…One of the potential applications is medical uses is to build sustained drug delivery system on which many developments have been made. Jackaniz, 1 Yolies,2 and Beck et al 3 ) studied the so called long-acting contraceptive devices using polylactides (PLA) as carrier. Polin 4 used copolymers of aminoacid as carrier.…”

Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules.

“…A peptide administered by a controlled delivery system that would lead to a constant release over a prolonged period of time could provide a continuous biological effect. Recently, a polymer of poly(DL-lactide-co-glycolide) (PLG) has been used to formulate microcapsules with steroids for long-acting contraceptive delivery systems (22)(23)(24) (26).…”

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“…In the following research, they developed a new sustained-release, injectable contraceptive which provides continuous controlled release of the steroid norethisterone, and the main drug can be slowly released from the microcapsules following intramuscular injection at a rate of 0.90 microgram/day from the polymer matrix. The results indicated ovulation functions was inhibited for 6 months and each one resumed normal ovulation within 1-2 weeks after the norethisterone blood level fell below the limit of detection 37 . However, tests showed burst effects were still remained in vivo release and the researches in the following years were still focused on hormone drugs.…”