New macroporous calcium phosphate glass ceramic for guided bone regeneration

Navarro, Melba; Valle, Sergio del; Martı́nez, Salvador; Zeppetelli, S.; Ambrosio, Luigi; Planell, Josep A.; Ginebra, Maria‐Pau

doi:10.1016/j.biomaterials.2003.11.012

Cited by 122 publications

(107 citation statements)

References 23 publications

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“…In this sense, it is relevant to note that the techniques used to obtain macroporous cements are different from those used to prepare macroporous ceramics or glasses, since in the case of ceramics the porogenic agent is destroyed during sintering, and therefore its biocompatibility is not a special requirement to be fulfilled. [4][5][6][7][8][9][10][11][12] The situation is completely different for CPC, since the cement is supposed to be implanted as a fresh and viscous paste, and the setting reaction occurs within the body. Therefore, the porogenic agent should be biocompatible.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

Ginebra¹,

Delgado²,

Harr³

et al. 2006

J Biomedical Materials Res

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One of the main challenges in the investigation on calcium phosphate cements (CPC) lies in the introduction of macroporosity, without loosing the self-setting ability and injectability, characteristic of the cement-type materials. The benefits of macroporosity are related to the enhancement of bone regeneration mechanisms, such as angiogenesis and tissue ingrowth. In this work, the feasibility to obtain self-setting injectable macroporous hydroxyapatite foams by the incorporation of a protein-based foaming agent to a CPC is demonstrated. Albumen is combined with an alpha-tricalcium phosphate [Ca3(PO4)2, alpha-TCP] paste, which hydrolyzes to a calcium deficient hydroxyapatite during the setting reaction. A systematic study is presented, where the effect of different processing parameters is analyzed in terms of porosity, setting properties, injectability, and compressive strength. Self-setting foams with porosities up to 70%, which maintain their porous structure after injection, are obtained. These injectable foams can be used both for direct in vivo applications and for the fabrication of low temperature tissue engineering scaffolds.

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Section: Introductionmentioning

confidence: 99%

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

Ginebra¹,

Delgado²,

Harr³

et al. 2006

J Biomedical Materials Res

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“…In addition, BG-ceramics elaborated from CaP degradable glasses as well as BGs, and CPC foams have been used as templates for in situ regeneration with very promising results (Gong et al 2001;Yuan et al 2001;Almirall et al 2004;Navarro et al 2004a;Ginebra et al 2007).…”

Section: Third Generationmentioning

confidence: 99%

Biomaterials in orthopaedics

Navarro

Michiardi

Castaño

et al. 2008

J. R. Soc. Interface.

1,288

730

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At present, strong requirements in orthopaedics are still to be met, both in bone and joint substitution and in the repair and regeneration of bone defects. In this framework, tremendous advances in the biomaterials field have been made in the last 50 years where materials intended for biomedical purposes have evolved through three different generations, namely first generation (bioinert materials), second generation (bioactive and biodegradable materials) and third generation (materials designed to stimulate specific responses at the molecular level). In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field.

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“…However, pore sizes of 300 µm and larger are recommended in order to facilitate enhanced formation of de novo bone and blood capillaries 32 as well as accommodate osteons that have a size of approximately 220 µm. 33 The pores within a BGS must be fully interconnected to facilitate in-growth of blood vessels and eventual formation of new bone. 29 Bone can only be formed by deposition on a suitable surface that is within 200 µm of a blood supply so that it can receive nutrients by way of diffusion.…”

Section: Introductionmentioning

confidence: 99%

High-strength scaffolds for bone regeneration

Meredith

Mallick

2015

Bioinspired, Biomimetic and Nanobiomaterials

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Repair of large skeletal defects that are intrinsic to skeletal stability represents the greatest challenge for orthopaedic surgeons. IntroductionBone defects arising from disease, trauma, infection or genetic abnormality are reconstructed with non-biodegradable materials such as stainless steel or titanium to restore skeletal function. 2,3These materials have been associated with long-term problems such as loosening, 4 peri-prosthetic fracture and infection. 5The modern approach is marked by a shift in emphasis from replacement to regeneration of tissue. 6,7 This is achieved by way of human-or animal-derived grafts (autograft, allograft or xenograft), bone graft substitute (BGS) materials, growth factors 8 or bioinorganics. 9 The drawbacks associated with human-and animal-derived grafts such as limited availability, high cost, poor remodelling, donor site morbidity, delayed healing and disease transmission have driven extensive research into synthetic alternatives. [10][11][12][13] The principal advantages of BGSs are unlimited supply, ease of sterilisation and storage, predictable mechanical properties, excellent bone in-growth and moderate cost. 14,15 Bone defects can be categorised into those that are intrinsic to skeletal stability and those that are not. Currently, there are numerous commercially available low-strength, void-filling BGS products but none are indicated to offer structural support to the skeleton. [16][17][18] Thus, there is an urgent need for BGSs that can replace allogenous or autogenous grafts in large defects, for example, in resections for infection or tumour. In these instances, bone grafts can be as large as 20 cm and their locations (joints, spine and long bones) require them to bear load and function with instrumentation to maintain the stability of the skeleton.2,19-21 Non-structural biomaterials can repair segmental defects in combination with instrumentation such as plates and screws but these require an additional retrieval procedure.22 A BGS material with the strength of cortical bone will benefit many patients and be particularly useful in spinal arthrodesis where high strength and osteoinductivity are essential to ensure rapid fusion. 23,24High-strength scaffolds for bone regeneration Meredith and Mallick

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New macroporous calcium phosphate glass ceramic for guided bone regeneration

Cited by 122 publications

References 23 publications

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

Biomaterials in orthopaedics

High-strength scaffolds for bone regeneration

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