Imaging of materials that contain nuclei of nonzero spin values has become a valuable tool in science, medicine, and industry. The principal use of MRI is to create an image of the distribution of certain physical properties of a substance, whether in the fluid‐filled rock surrounding an oil well, soil, food‐processing, industrial process control or a human subject. These physical properties imaged include the chemistry of the material, its fluidity, its interactions with other materials in the molecular‐level neighborhood, and even the flow of liquids within the object. Magnetic resonance phenomena occur on a timescale that is short relative to many chemical reactions and can often be used to investigate the kinetics of chemical reactions.
Many different elements are amenable to investigation by magnetic resonance, but the sensitivity of MR is poor. As a result of this insensitivity, magnetic resonance is not suited to detecting of chemical moities of less than millimolar quantities. For the same reason, gases are largely unsuitable to investigation by magnetic resonance, except for hyperpolarized gases
3
He and
129
Xe.
All solid or liquid objects, that bear suitable nuclei can be imaged. However, spins within solid materials lose their signal on a very short timescale. This brevity of signal lifetime makes imaging quite difficult, yet not impossible.
Examples of nuclei that bear a magnetic moment, or nonzero spin include hydrogen, helium‐3, xenon‐129, phosphorus, lithium, fluorine, carbon‐13 and sodium‐23.
An important and recent use of the MR phenomenon is in medical imaging. The reason for the success of MRI in medical imaging is fourfold. The first is the abundance of hydrogen in the human body. Hydrogen nuclei in the brain are about 70 Molar in concentration which is much higher than any other material that can be detected by NMR. The second is that the hydrogen is distributed in the organs in a way which allows using the MR signal to create images. The third is that imaging of hydrogen produces exquisitely detailed images of internal organ structure. The fourth is the functional data that can be extracted. These data include molecular diffusion, distribution of chemical moieties, flow, flow in the capillary bed, oxygen utilization, magnetization transfer rates, and disruption of the blood–brain barrier.
Basic MRI physics, imaging processing and k‐space, endogenous image contract and other mechanisms are discussed.